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”Bortom förnybart” är rapportens underrubrik men också en sammanfattning av en av de viktigaste slutsatserna från syntesarbetet. Fjärrvärmesverige har nästan uppnått sin vision om en fossilfri värmetillförsel. Detta är en fantastisk prestation som behöver ersättas av nya framtida miljö-, klimat- och samhällsmål att sträva efter. Framtida forskning kring fjärrvärme bör utgå från en tydligare vision

Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA

Background When the lectinlike oxidized low-density lipoprotein (ox LDL) receptor-1 ( LOX -1), a scavenger receptor for ox LDL , binds ox LDL , processes leading to endothelial dysfunction and inflammation are promoted. We aimed to study release mechanisms of LOX -1 and how circulating levels of soluble LOX -1 ( sLOX -1) relate to plaque inflammation and future risk for ischemic stroke. Methods an

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate if PBVV differs in patients with heart failure compared to healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated f

OBJECTIVE: To investigate the feasibility of synchrotron radiation-based phase contrast enhanced micro-computed tomography (SR-PhC-μCT) for imaging of human meniscus. Quantitative parameters related to fiber orientation and crimping were evaluated as potential markers of tissue degeneration.DESIGN: Human meniscus specimens from 10 deceased donors were prepared using different preparation schemes:

Introduction eHealth, defined by WHO as: “the transfer of health resources and healthcare by electronic means” are expected to increase communication between healthcare providers and patients and increase accessibility and patient participation in healthcare. The aim of this research programme is to: 1) develop a sustainable multidisciplinary environment for advancing, evaluating, and implementing

Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 Å resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized in

Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This st

Nanoplastics have been proven to induce toxicity in diverse organisms, yet their effect on soil microbes like bacteria and fungi remains largely unexplored. In this paper, we used micro-engineered soil models to investigate the effect of polystyrene (PS) nanospheres on Pseudomonas putida and Coprinopsis cinerea. Specifically, we explored the effects of increasing concentrations of 60 nm carboxylat

The great variety of earth's microorganisms and their functions are attributed to the heterogeneity of their habitats, but our understanding of the impact of this heterogeneity on microbes is limited at the microscale. In this study, we tested how a gradient of spatial habitat complexity in the form of fractal mazes influenced the growth, substrate degradation, and interactions of the bacterial st

Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in

BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.METHODS: We conducted a cross-sectional study of 8973 participants (50

Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy techniques have been used extensively for metabolite profiling. Although combining these two analytical modalities has the potential of enhancing metabolite coverage, such studies are sparse. In this study we test the hypothesis that combining the metabolic information obtained using liquid chromatography (LC) MS and 1H NMR s

Sedan 1970-talet har antalet rapporterade cancerfall dubblerats, dels på grund av förändrade levnadsvanor och dels på grund av bättre screeningmetoder som upptäcker cancern i tidigt skede. Tidig upptäckt av cancern i kombination med utvecklad cancerbehandling har bidragit till att risken för att avlida av cancer har minskat. Cancerbehandling sker huvudsakligen genom operation, strålbehandling elleAim: The tomotherapy system offers two radiation techniques, TomoHelical (TH) and TomoDirect (TD). The aim of this master thesis was to evaluate TD as a treatment alternative mainly by comparing TD treatment plans with 3DCRT plans and comparing TD plans with TH plans, separately, in the thoracic and abdominal regions. An additional aim was to examine if the current patient specific quality control

År 2014 startade Region Skåne en basutbildning för alla chefer inom organisationen i Region Skåne. Basutbildningen infördes med anledning av att säkerställa att alla chefer befattade en gemensam grund att utgå ifrån inför kommande ämnesspecifika arbetsuppgifter. Under årens lopp har få utvärderingar utförts vilket har resulterat i att basutbildningens effektivitet i nuläget är av okänd karaktär. •

Renskötselrätten är en samlingsterm för de rättigheter som tillkommer den samiska befolkningen och som regleras i rennäringslagen. Rätten går att jämföra med andra rättigheter - t.ex. servitut och nyttjanderätter - och kan kategoriseras som särskild rätt till fastighet. En stor skillnad från andra rättigheter är att renskötselrätten grundar sig på samernas traditionella brukande av mark och regler

På senare år har det diskuterats frenetiskt om arbetet mot gängkriminaliteten. Inom ramen för regeringens 34-punktsprogram, ett program bestående av flera förslag till åtgärder mot gängkriminaliteten i Sverige, infördes en ny tillfällig lag som gäller under en femårsperiod. I april 2020 trädde lagen (2020:62) om hemlig dataavläsning i kraft, för att möjliggöra för de brottsbekämpande myndigheternaOver the past years in Sweden, there has been a lot of discussions concerning the struggle on gang-related misconduct. Enclosed in the framework of the Swedish government's 34-point program, moreover an agenda comprising several proposals for measures to combat gang-related criminality, a new temporary legislation was introduced for a period of five years. In April 2020, the Secret Data Interc

Sedan kommunalskattelagen (1928:379), KL, infördes år 1928, har oinskränkt skattskyldighet för fysiska personer förelegat vid bosättning eller vid stadig-varande vistelse i Sverige. Stadigvarande vistelse har inte definierats i lagtext, men den allmänna uppfattningen har sedan 1928 varit en vistelse överstigande sex månader. Inskränkt skattskyldighet har vidare förelegat för fysiska perso-ner endaSince the Municipal Tax Act was implemented in 1928, a person has been considered a tax resident in Sweden either by being a resident in Sweden or by permanently staying in Sweden. What constitutes a permanent stay has not been defined in the law. However, the general perception has, since 1928, been that a stay that exceeds six months should constitute a permanent stay. During the beginning of th