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Abstract in Danish Kapitlet viser først gennem en historisk analyse, at det er et relativt nyt fænomen, at de pårørende til mennesker, som trænger til hjælp i det danske sundhedssystem, på hospitalet, på plejehjemmet, i eget hjem og alle andre steder, beskrives og tænkes som en del af sundhedsvæsnet. Herefter gøres analytiske nedslag på hospitalet, plejehjemmet og i hjemmeplejen mhp. at se, hvorda
Företag marknadsför över 200 mjukvaror för artificiell intelligens (AI) inom radiologi.Vårdgivare behöver ha möjlighet till opartisk och kvalitetssäkrad utvärdering.Projektet Validering av AI inom bröstradiologi (VAI-B) startades för att möta detta behov, initialt inom mammografiscreening.
Aims Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations
Background: Early detection of treatment response is important for the management of patients with malignant brain tumors such as glioblastoma to assure good quality of life in relation to therapeutic efficacy. Aim: To investigate whether parametric response mapping (PRM) with diffusion MRI may provide prognostic information at an early stage of standard therapy for glioblastoma. Materials and met
Background: Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis. Methods: Study participants (n = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes. A coronary artery calcium score (CACS) > 0 defi
B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy and is driven by multiple genetic alterations that cause maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes but are associated with significant toxicity and risk of side effects, highlighting the necessity for
Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD
A significant problem in diffusion MRI (dMRI) is the lack of understanding regarding which microstructural features account for the variability in the diffusion tensor imaging (DTI) parameters observed in meningioma tumors. A common assumption is that mean diffusivity (MD) and fractional anisotropy (FA) from DTI are inversely proportional to cell density and proportional to tissue anisotropy, resp
The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demons
Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L
Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects wi
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Preclinical research relies on xenograft mouse models, but these models preclude the human-specific functional interactions of stem cells with their bone marrow microenvir
Soft regionalism och regionala identiteter i Storbritannien har sällan blivit utforskade utöver nationella debatter avseende Skottland, England, Wales och Cornwall. Dessutom har även många senare regionala studier i England försummats helt. Denna studie har sin bakgrund i den pågående debatten om decentrialisering (devolution) och skapandet av nya regionala myndigheter och urbaner-regioner i StorbSoft regionalism and regional identities in Great Britain has seldom been explored beyond the national debates of Scotland, Wales, and Cornwall. Many recent local studies in England have, too, been neglected. This study is set against the backdrop of the ongoing debates around devolution within the United Kingdom and the creation of new regional authorities and city-regions. This thesis investigat
Tanken på självkörande bilar har funnits nästan lika länge som det har funnits bilar. Denna uppsats har ämnat utreda vilka rättsekonomiska konsekvenser en skada vållad av ett förarlöst fordon medför samt hur lagstiftningen ur ett de lege ferenda-perspektiv bör vara utformat utifrån rättsekonomiska teorier. Rättsekonomi sträva efter ekonomisk effektivitet. Detta skapar välstånd för individer och väThe idea of self-driving cars has been around almost as long as there have been cars. This thesis investigates the legal consequences of damages caused by a driverless vehicle and how the legislation out of a de lege ferenda-perspective should be, based on legal-economic theories. Law and economics theories strives for economic efficiency. This creates wealth for individuals and welfare in society
Målet med denna studie åir att bestämma tryck och temperatur ftir en del av det Östra Segmentet i Svekonorvegiska Provinsen. Henestad metabasiten består dels av gabbro och dels av metamorf granatamfibolit. Gradvisa övergångar mellan dessa ändled kan observeras över korta avståLnd (dm-m). Stuffer fiån två olika områden togs lor analys. Båda är granatamfiboliter, men W23 har stöme granater (6 mm) ocThis study presents the results of P-T estimation of amphibolite facies rocks in the Eastern Segment of the Sveconorwegian orogen. The investigated Hìrrestad metabasite consists of both unmetamorphosed gabbro and metamorphosed gamlet amphibolite and gradual transitions over a few meters between these end-members. Trio sampl.s *".e collectåd and used in this study._!ample.W23 i¡ an amphibolite
Det har länge talats om stadskärnor i kris i media och bland experter. Traditionella funktioner i stadskärnor såsom handel har flyttats till externa köpcentrum och internet. Det finns många olika perspektiv och teorier kring hur städer kan bli mer attraktiva och locka tillbaka människor till städerna, men många av dem saknar ett helhetsperspektiv på vad som utgör stadskärnornas unika konkurrensför
30 juni 2022 trädde en omfattande ändring av lag (1982:80) om anställ-ningsskydd i kraft. Ändringarna syftade dels till att göra det lättare för ar-betstagare att komma in samt få en trygg anställning på arbetsmarknaden, dels att göra det enklare och mer flexibelt för arbetsgivare att anställa och avsluta anställningar och därmed minska riskerna med att anställa. Bland annat bytte allmän visstidOn June 30, 2022, a comprehensive amendment to the Employment Protec-tion Act (1982:80) came into effect. The changes aimed to make it easier for employees to enter and secure employment in the labor market, as well as to simplify and provide more flexibility for employers in hiring and terminating employment, thereby reducing the risks associated with hiring. Amongst other changes "general f
