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INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant
Introduction Distinguishing between homicide and suicide in cases of single stab injuries to the trunk can be challenging, particularly in the absence of clear contextual information. This study aims to address this issue by developing the MODSIT score (Manner of Death in Stab Injuries to the Trunk)—an evidence-based scoring system designed to standardise forensic manner of death assessments. Meth
Urban green spaces provide important ecosystem services that support human well-being and climate adaptation in cities. As urbanisation and densification increases, municipalities face chal lenges in promoting and safeguarding these areas. This study investigates the current methods and tools used by municipalities in southern Sweden to assess urban green spaces with regard to ecosystem service
The prevalence of type 2 diabetes (T2D) is increasing worldwide, but current treatments have limitations. miRNAs may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D is associated with altered expression and DNA methylation of miRNAs using adipose tissue from 14 monozygotic twin pairs discordant for T2D. Four members each of the miR-30
Background: Radical prostatectomy reduces mortality among patients with localised prostate cancer. Evidence on whether different surgical techniques can affect mortality rates is lacking. Objective: To evaluate functional and oncological outcomes 8 yr after robot-assisted laparoscopic prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). Design, setting, and participants: We enroll
Decisions to admit or refuse admission to intensive care for acute exacerbations of COPD (AECOPD) can be difficult, due to an uncertainty about prognosis. Few studies have evaluated outcomes after intensive care for AECOPD in patients with chronic respiratory failure requiring long-term oxygen therapy (LTOT). In this nationwide observational cohort study, we investigated survival after first-time
I takt med att världen globaliseras allt mer uppstår också nya typer av utma-ningar. Skatteplanering och skatteflykt orsakar idag stor skada på länders skattebas. För att motverka detta har OECD sedan 2013 arbetat med ett pro-jekt som kallas för BEPS (Base Erosion and Profit Shifting). BEPS består av 15 åtgärder för att motverka erodering av skattebasen och vinstallokering. Projektet har beskrivitAs the world becomes increasingly globalized, new types of challenges arise. Tax planning and tax evasion continue to cause significant harm to the tax bases of countries. To combat this, the OECD has been working on a project called BEPS (Base Erosion and Profit Shifting) since 2013. BEPS consists of 15 actions aimed at countering the erosion of the tax base and profit shifting. The project has b
This paper analyzes the use of populist rhetoric by armed groups as a means to portray themselves as a political actor, focusing on Viv Ansanm-spokesperson Jimmy “Barbecue” Chérizier’s anti-elite discourse in 2023 and 2024 through a qualitative content analysis. This is achieved through building on existing literature discussing limits of Haitian statehood as well as the historical role of non-sta
Global agri-food systems are in urgent need of a sustainability transformation guided by best practices of agroecology. The study used the Tool for Agroecological Performance Evaluation (TAPE) to assess the performance of seven market gardens in southern Sweden in comparison to the Swedish horticultural sector. The findings indicate that all participating market gardens could be considered agroeco
Denna uppsats undersöker hotspot-modellen i Grekland och dess förenlighet med de grundläggande rättigheter som fastställs i Europeiska konventionen om de mänskliga rättigheterna, närmare bestämt artiklarna 3 och 5. Hotspotsystemet infördes som en nödåtgärd som svar på det ökade antalet ankommande flyktingar vid EU:s yttre gränser under 2015-2016. I Grekland utvecklades det dock till en mer permaneThis thesis examines the hotspot approach in Greece and its compatibility with the fundamental rights enshrined in the European Convention on Human Rights, with a particular focus on Articles 3 and 5. The hotspot system was introduced as an emergency measure in response to the increased number of arrivals at the EU’s external borders in 2015-2016. In Greece, however, it evolved into a more permane
Digitalisering och sociala medier har förändrat hur konsumenter rör sig genom kundresan. Plattformar som TikTok har bidragit till en mer komplex och icke-linjär kundresa där inspiration, informationssökning, interaktion och konsumtion sker parallellt. Samtidigt har användargenererat innehåll fått ökad betydelse för hur konsumenter värderar information och fattar köpbeslut. Mot denna bakgrund under
The mcstas_gisans framework is a collection of Python scripts and modules tofacilitate the simulation of grazing-incidence small-angle neutron scattering(GISANS) experiments. This approach combines McStas instrument simulationwith BornAgain sample modeling capabilities. The Monte Carlo Particle Listsformat for particle trajectory allows exchange between simulations that enablesseamless transition
BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease.PURPOSE: To explore if increased l
Carbon-14 (14C) is an important contributor to the collective effective dose to the public due to releases from nuclear power plants (NPPs). In Sweden, only airborne emissions of 14C from NPPs are currently routinely monitored, and the existing data on waterborne 14C discharges are limited. A recent study of 14C in brown algae (Fucus spp.) in Swedish coastal waters showed higher F14C values collec
INTRODUCTIONThis study examines medication reviews (MRs) among people living with dementia (PWD) in Sweden, focusing on frequency and factors influencing access.METHODSUsing nationwide register data, all diagnosed PWD from 2010 to 2016 were assessed for MR receipt in 2015 and/or 2016. The analysis guided by the Andersen healthcare utilization framework, considered predisposing, enabling, and need-
Introduction: This multicenter, prospective observational study aimed to evaluate the performance of the StatStrip® Lactate 2 (Nova Biomedical, Waltham, US) point-of-care device for fetal blood lactate measurement and to determine the corresponding lactate value equivalent to the established intervention cutoff used with the outgoing StatStrip® Lactate device. Material and Methods: The study was c
Patients with dementia experience a steady deterioration in cognitive function that increases mortality and impairments. Moreover, dementia is also anticipated to increase significantly in prevalence as the world's population ages, placing a strain on healthcare systems throughout the globe. Hence, early identification and prediction of dementia are essential due to timely treatments, enhanced pat
Hydrogen energy plays a pivotal role in the sustainable energy transition. Methanol steam reforming offers an efficient route for decentralized hydrogen production, yet catalyst limitations persist. This work employs entropy engineering to design lanthanide perovskite catalysts via sol-gel synthesis. Structural analyses reveal entropy-driven lattice distortion, enhanced disorder, and elevated oxyg
