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Coronapandemin i kombination med ökad e-handel har varit ännu ett svårt slag mot svenska stadskärnor. Under 2020 och 2021 har flera stora butikskedjor valt att lämna stadskärnorna till förmån för externa handelsplatser och onlinehandel. Larmrapporterna och lösningar på problemet har varit många under 2021. Denna rapport är en analys och utvärdering av vad som sagts i media, tidigare forskning och

Background and objectives Cognitive and physical difficulties are common in survivors of out-of-hospital cardiac arrest (OHCA); both survivors and close family members are also at risk of developing mood disorders. In the UK, dedicated follow-up pathways for OHCA survivors and their family are lacking. A cohort of survivors and family members were surveyed regarding their experience of post-discha

On 12 July 2021 the World Health Organization (WHO) Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing published a set of reports entitled Human Genome Editing: A Framework for Governance and Recommendations. These reports provide valuable advice and recommendations on appropriate institutional, national and global governance mechanisms fo

Hypotension after cardiac arrest could aggravate prolonged hypoxic ischemic encephalopathy. The association of circulatory shock at hospital admission with outcome after cardiac arrest has not been well studied. The objective of this study was to investigate the independent association of circulatory shock at hospital admission with neurologic outcome, and to evaluate whether cardiovascular comorb

Introduction It is standard of care to provide sedation to critically ill patients to reduce anxiety, discomfort and promote tolerance of mechanical ventilation. Given that sedatives can have differing effects based on a variety of patient and pharmacological characteristics, treatment approaches are largely based on targeting the level of sedation. The benefits of differing levels of sedation mus

Background: Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Blood biomarkers offer clinicians the potential to improve prognostication. Previous studies suggest that circulating non-coding RNAs constitute a reservoir of novel biomarkers. The

Background: Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions have no interactions on outcomes. Here, we present a protocol for a simulation study investigating the consequences of different levels of interactions between the trial interventio

How can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The CoHow can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The Co

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

This paper contributes to the empirical question of the labour organization and gender division of labour in a semi-landless rural group during the second half of the nineteenth century, a period charac-terized by developing agrarian capitalism. Thereby, we also add to the broader question of the role of gender division of labour in economic transformation. Through a triangulation of sources – cro

We do not yet know how the robotization of eldercare will unfold, but one thing is clear: technology mediates human practices and experiences [1]. As such, care robots will co-shape the actions of care givers and older people and influence the perceptions and experiences of old age. The robotization of eldercare means that it is essential for developers, policy makers, and researchers to become in

Different strategies have been used to stimulate a return to work (RTW) among individuals suffering from long-term ailments. In Sweden a new law on "resting disability pension" permits disability pensioners to go back to work without jeopardising their benefits. In this study different variables related to RTW during 2000 by means of this legislation were identified among disability pensioners witDifferent strategies have been used to stimulate a return to work (RTW) among individuals suffering from long-term ailments. In Sweden a new law on "resting disability pension" permits disability pensioners to go back to work without jeopardising their benefits. In this study different variables related to RTW during 2000 by means of this legislation were identified among disability pensioners wit

Hur kan vi skapa ett hållbart arbetsliv där individer mår bra, kan, vill och orkar befinna sig? Hur kan arbetsgivare, organisationer, företag ta till vara på det humankapital som individer utgör? Hur kan hälsa, inklusion, motivation, kunskap och kompetens värnas och utvecklas genom hela arbetslivet? I ett framtidsperspektiv kommer efterfrågan på arbetskraft som kan och vill arbeta till en högre ålHur kan vi skapa ett hållbart arbetsliv där individer mår bra, kan, vill och orkar befinna sig? Hur kan arbetsgivare, organisationer, företag ta till vara på det humankapital som individer utgör? Hur kan hälsa, inklusion, motivation, kunskap och kompetens värnas och utvecklas genom hela arbetslivet? I ett framtidsperspektiv kommer efterfrågan på arbetskraft som kan och vill arbeta till en högre ål

For patients with gastroenteropancreatic neuroendocrine tumours (GEP-NET), health-related quality of life (HRQoL) is important. Meanwhile, whether tumour volume is associated with HRQoL is unknown. Hence, the aim of this study was to assess if total somatostatin receptor expressing tumour volume is correlated with HRQoL in patients with metastatic GEP-NET. Some 71 patients were included in the stu

Introduction: While it is recognized that there are costs associated with postoperative patient follow-up, risk assessments of catastrophic health expenditures (CHEs) due to surgery in sub-Saharan Africa rarely include expenses after discharge. We describe patient-level costs for cesarean section (c-section) and follow-up care up to postoperative day (POD) 30 and evaluate the contribution of follo

Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of postinjury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC w

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in th

Dette retsfilosofiske storværk er bygget op omkring en række historiske og teoretiske kapitler, der trækker en linje fra antikken, middelalderen og oplysningstiden over bl.a. retspositivismen i første halvdel af det 20. århundrede, den amerikanske pragmatisme og til nyere teorier i europæisk og amerikansk retsfilosofi. Desuden sættes der fokus på centrale temaer som feminisme, retfærdighedsfølelse

BACKGROUND: To strengthen palliative care for children in the Nordic countries, an updated status of current needs, resources, clinical services, education, and research is necessary to align and consolidate future research. A Nordic research collaboration initiative for children with palliative care needs was assembled in 2023. Building on this initiative, this paper presents an overview of pedia