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Small interfering RNAs (siRNAs) are a rapidly growing class of oligonucleotide therapeutics that modulate gene expression by inducing targeted mRNA degradation. siRNAs are potent and their effect is long-lasting, making them promising candidates for chronic neurodegenerative disease. However, siRNAs can elicit both on- and off-target toxicity, and while acute neurotoxicity has been characterized,
