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The recognition of a strong etiological relationship between infection with high-risk human papillomavirusses and cervical cancer has prompted research to develop and evaluate prophylactic and therapeutic vaccines. One prophylactic quadrivalent vaccine using L1 virus-like particles (VLP) of HPV 6, 11, 16 and 18 is available on the European market since the end of 2006 and it is expected that a sec
Background/Aims: The liver is a major target organ of graft versus host disease (GvHD) with massive infiltration of alloreactive lymphocytes resulting in hepatitis and hepatocyte injury. Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known. Methods: We have devel
Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1 GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse im
The Large Hadron Collider (LHC) will be ready for proton-proton collisions in the year 2005 and the ATLAS detector will be one of the two experiments at the LHC which will explore a new and higher energy range for particle physics. In this thesis, an analysis of the power of the ATLAS detector to detect a Standard Model Higgs boson has been performed. It is shown that it will be possible to discov
Colorectal cancer (CRC), one of the leading causes of cancer-related deaths in the western world, is the third most common cancer for both men and women. As a heterogeneous disease, colon cancer (CC) is caused by both genetic and epigenetic changes. The prognosis for CRC is affected by a variety of features, including late diagnosis, lymph node and distant metastasis. The cysteinyl leukotrienes (C
Although combined heat and power (CHP) production in Sweden is already largely decarbonised, this technology has further potential to alleviate pressing environmental concerns. Today, biobased CHP plants connected to district heating (DH) grids dominate the Swedish residential heating sector. The societal context in which CHP plants operate is, however, subject to continuous change. New aims and r
Registered nurses with a doctoral degree are important for the quality of care, nursing education, and nursing research. Still, postgraduate career paths are criticized for being too vague. To enable career path development, mapping of the current situation appears fundamental. The objective was therefore to chart the current professional positions and work conditions and to explore the future car
There has been a substantial rise in coronavirus disease 2019 (COVID-19) cases after adjusting the dynamic zero-COVID policy in China. We conducted a survey to investigate the self-perceived symptom profile and its association with vaccination status during this outbreak. There were 552 individuals in this survey. The infected individuals displayed various symptoms associated with different factor
BACKGROUND: Observational studies have revealed that type 2 diabetes (T2D) is associated with an increased risk of peripheral artery disease (PAD). However, whether the two diseases share a genetic basis and whether the relationship is causal remain unclear. It is also unclear as to whether these relationships differ between ethnic groups.METHODS: By leveraging large-scale genome-wide association
Drug side effects (DSEs) or adverse drug reactions (ADRs) are a major concern in the healthcare industry, accounting for a significant number of annual deaths in Europe alone. Identifying and predicting DSEs early in the drug development process is crucial to mitigate their impact on public health and reduce the time and costs associated with drug development. Objective: In this study, our primary
Background: Growing evidences have advocated the potential benefits of traditional Chinese exercise (TCE) on symptomatic improvement of knee osteoarthritis (KOA). However, most of them have been derived from cross-sectional studies or case reports; the effectiveness of TCE therapies has not been fully assessed with a randomized control trial (RCT). In order to evaluate the combined clinical effect
INTRODUCTION: Mechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients. METHODS AND ANALYSIS: This is a preplanned
Direct ground cooling is a method for cooling buildings whereby free cooling is provided by circulating water through borehole heat exchangers (BHEs). Since no refrigeration cooling is involved, supply water temperature to the building's cooling system is dependent mainly on BHE sizing. This study investigates the sizing of BHEs for direct ground cooling systems, with a particular focus on the inf
Denna avhandling utforskar den meta-etiska frågan: Vilka egenskaper krävs av ett normativt kritiskt begrepp så att det både kan (a) härledas från den sociala faktiska verkligheten av gällande normer, praktiker och institutioner i ett givet samhälle och (b) vara utgångpunkt för radikal kritik? Radikal kritik förstås i avhandlingen som en kritik bortom anklagelser om partiskhet gentemot det rådandeThis thesis explores the meta-ethical question: What properties would be required of a normative critical concept in order for it to be (a) derived from the social facticity of prevailing norms, practices and institutions in a given society and (b) still be capable of informing radical critique? This thesis takes radical critique to mean one that escapes all charges of status quo biases and thus t
This case study investigates the potentials, greenhouse gas (GHG), and energy performance of forest residue biofuels produced by new and emerging production technologies, which are commercially implemented in Sweden for heavy transport. The biofuel options included are ethanol (ED 95), hydro-processed vegetable oil (HVO), and liquefied biogas (LBG) produced from logging residues in forestry and sa
