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Herein, we present a case of severe immune-related adverse events (irAEs), myocarditis with myositis, and myasthenia gravis overlap syndrome (IM3OS) in a patient receiving an immune checkpoint inhibitor (ICI), as adjuvant therapy after surgery for muscle-invasive bladder cancer. An 80-year-old woman who had undergone a total cystectomy for bladder cancer presented with ptosis, diplopia, and paraly
Rapporten visar att det finns en gedigen vetenskaplig evidensbas för att utforma åtgärder inom den gemensamma jordbrukspolitiken som bidrar till restaurering av jordbrukslandskap i linje med EU:s naturrestaureringsförordning. Evidensbasen kan stärkas genom en systematisk sammanställning av resultat från restaureringsprojekt, och författarna föreslår adaptiv restaurering för att hantera kontextbero
The topic of this study is to develop and validate an analysis method of nicotine nasal spray produced at McNeil AB. When developing the analysis method, several parameters were determined in advance to make the method more similar to other analysis methods at the company, making it more practical. However, other parameters were adjusted with the aim to improve the resolution and to fulfil the upd
Kulturell kontext lyfts allt oftare som en viktig aspekt vid textanpassning för andraspråksbrukare. I den här studien har kulturell kontext, som begrepp och fenomen, undersökts och problematiserats närmare. Studien har genomförts med kvalitativa metoder i form av litteraturstudier och intervjuer med andraspråksbrukare. I resultatet av detta framgår det att begreppet kulturell kontext i dagsläget ä
E-handelsindustrin har länge använt sig av third-party cookies för att spåra internetanvändare, men 2024 kommer dessa att ha fasats ut från de största webbläsarna. Det nuvarande kunskapsläget kan varken besvara vad e-handlarna anser vara alternativ till third-party cookies eller vilka faktorer som leder till acceptans av dessa. Syftet med studien är därför att kvalitativt beskriva vad svenska e-ha
The substantial growth of private health insurance in 21st century Sweden has sparked debates about its potential effect on waiting times within the public health care system. Some argue that individuals with private health insurance are prioritized in the waiting list for health care, potentially leading to longer waiting times for those without private coverage. Conversely, others argue that pri
Purpose: Brand Activism is a phenomenon that only recently became an area of greater interest. The aim of this paper is to follow a call for research and develop a framework that aids brand managers and other decision makers to identify essential prerequisites that their brand should have in place to increase the likelihood for successful Brand Activism. Design/ Methodology approach: The paper em
Genom en feministisk kritisk diskursanalys granskar denna studie Sierra Leones nationella handlingsplan för implementeringen av FN:s säkerhetsråds resolutioner 1325 och 1820. Syftet är att undersöka huruvida könade diskurser inom resolution 1325 överförs till nationella handlingsplaner samt vilken påverkan detta har för föreställningar om kvinnor och könsroller inom sektorn för fred och säkerhet. Through the use of feminist critical discourse analysis this study examines Sierra Leone’s National Action Plan in its implementation of UN Security Council Resolutions 1325 and 1820. The aim is to investigate whether gendered discourses in resolution 1325 have been included in the national action plan and provide an assessment of the impact this has had on the perception of women and gender withi
This thesis explores stigma in regards to access to education for children affected by HIV/AIDS in Vietnam and strategies to overcome stigmatization. This study is based on previous research which claims that HIV-related stigma causes isolation, bullying and social exclusion among affected groups. As a result, Goffman’s theory of stigma was used together with Bourdieu’s theory of capital and Fouca
Background and Goal of StudyWe aimed to develop, implement and evaluate a mobile system using off-the-shelf components, torecord and review simulations and debriefings in four separate rooms during standardized simulation courses at multiple centres in Sweden. Ourrequirements were: high quality sound and video; easy to install, use and demount; suitable for transport by courier; no requirement to
Purpose: Defunctioning stoma (DS) has been suggested to mitigate the consequences of anastomotic leak (AL) after low anterior resection. Stoma reversal (SR) is commonly delayed for nonmedical reasons in many healthcare systems. This study investigated the impact of the elapsed time from AR to SR on postoperative 90-day complications. The secondary aim was to explore the independent factors associa
Background: With the availability of a wrist-worn device capable of acquiring two ECG leads with a single touch, synthesis of the 12-lead ECG may be accomplished to facilitate clinical interpretation. Objective: This study proposes an echo state network (ESN) for synthesizing the 12-lead ECG from two leads simultaneously acquired using a wrist-worn device. Methods: The wrist-worn device, equipped
Study region: Lake Vänern, the largest lake in the European Union, located in Sweden. Study focus: The study aimed to develop a spatially complete and temporally continuous lake surface water temperature (LSWT) dataset by fusing satellite remote sensing data with reanalysis products. Five satellite-derived LSWT products, including the Moderate Resolution Imaging Spectroradiometer (MODIS), were eva
Effluent wastewater contains organic micropollutants (OMPs) that harm aquatic ecosystems. Therefore, wastewater treatment plants (WWTPs) need to expand their facilities with advanced water treatment technologies. Water scarcity and improved effluent quality is encouraging the reuse of treated effluent. This study thus has a dual purpose: first, to evaluate OMP removal using two technique combinati
Although high-level evidence is currently lacking, noninferiority randomised controlled trials in predefined risk groups in non-muscle-invasive bladder cancer are under way to scientifically prove the safety of urinary biomarker-guided follow-up. To facilitate recommendations for clinical use, it is essential to comply with the EU certification for in vitro diagnostics and to demonstrate cost effe
A search is reported for long-lived dark photons with masses between 0.1 GeV and 15 GeV, from exotic decays of Higgs bosons produced via vector-boson-fusion. Events that contain displaced collimated Standard Model fermions reconstructed in the calorimeter or muon spectrometer are probed. This search uses the full LHC Run 2 (2015–2018) data sample collected in proton–proton collisions at s=13 TeV,
Objective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD). Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system. Methods: This was a prospective, international, multicente
The Islamic Republic of Iran (IRI) has employed assassinations and proxy violence as tools of statecraft. Dissidents in exile have been killed, targeted, or systematically threatened, while Israeli-linked entities across Europe have faced repeated attacks. In recent years, Tehran has increasingly outsourced these operations to state-linked criminal intermediaries. This paper analyzes Iran’s approa
