Filtyp
ObjectivesThis nested case–control study aimed to investigate the relationship between components of the Swedish food-based dietary guidelines (SDG) from 2015 and the risk of developing rheumatoid arthritis (RA).MethodsData were obtained from the prospective Malmö Diet and Cancer Study (MDCS) conducted 1991–1996. Diet was assessed at baseline using a validated diet history method. Incident RA case
Objectives: In SLE, anti-dsDNA can co-occur with autoantibodies against other chromatin components, like histones and nucleosomes. These antibodies induce type-1 interferon production, a hallmark of SLE. We measured ANA sub-specificities and investigated their associations to inflammatory biomarkers including interferon-regulated chemokines. Methods: We included 93 Sudanese and 480 Swedish SLE pat
Importance: The 2023 American College of Rheumatology and American Association of Hip and Knee Surgeons Clinical Practice Guideline concluded that obesity alone should not delay joint replacement. Therefore, a substantially increased utilization of joint replacement among patients with obesity could be expected. However, patients with obesity are at increased risk of revision, posing unique challe
BACKGROUND: Falls are common among older persons and can have a major impact on their lives. Wearable sensors used in free-living conditions (moving naturally in one's daily living environment) can be used to predict falls and fall risks. To understand if using the wearable sensors is an acceptable way for older persons to be screened for fall risks, it is important to have knowledge of older pers
Age-Friendly Cities and Communities (AFCC) is a key global WHO initiative aimed at fostering environments that promote healthy aging for everyone. As AFCC initiatives continue to expand, there is an increasing need to enhance monitoring and evaluation systems to effectively assess their progress and impact. However, significant knowledge gaps persist, particularly in the development of evaluation
Objective: Professional operatic singing is vocally demanding, making the maintenance of professional vocal health a paramount concern for the opera chorister. Occupational environment has been shown to affect vocal health for other vocally dependent professions. Hence, the objective of the current study was to explore what occupational environment factors affect the professional vocal health of S
Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque
Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort (n = 173; 86 full twin pairs, 1 singleton), including comprehensive measurements of obesity-related outcomes, mitochondrial DNA quantity and nuclear DNA methyla
About 4.4% of the global emissions of greenhouse gases can be ascribed to healthcare. Intensive care is among the most resource intensive specialties and the purpose of this study was to quantify the total climate impact of a Swedish intensive care unit (ICU) and identify modifiable elements that can lower the intensive care unit’s climate impact. A process-based life cycle assessment was conducte
Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an
We present the concept of our new high power laser facility Attohallen in Gothenburg, with focus on its first high-order harmonic generation beam line. The key specifications of this facility, including the architecture and operation of the femtosecond drive laser system, the XUV generation part of its first beam line for photon-demanding attosecond timing experiments in the energy range up to abo
Particle exchange heat engines are a novel class of cyclic heat engines that are all-electrical, contain no moving parts and can therefore be scaled down to nanometer size. At the center of their operation is the manipulation of a particle flow between a hot and a cold reservoir through energy filtering mechanisms, where their efficiency depends primarily on the sharpness of the energy filter. In
Background & aims: Colorectal cancer (CRC), particularly rectal cancer, often requires neoadjuvant radiotherapy (RT) as part of its treatment plan. Although effective, RT can cause significant gastrointestinal side effects. Because the onset of RT-induced tissue injury can be anticipated, there is an opportunity to apply preventive measures before the damage occurs. This study aimed to assess
To contribute to the development of effective support for early career researchers during and after doctoral education, the aim of this study was to examine the experiences of the early career transition after affiliation with an interdisciplinary graduate school, using the Swedish National Graduate School on Ageing and Health (SWEAH) as an example. Through qualitative interviews with 18 alumni, t
Bivalves are considered mainly filter-feeding organisms; they remove suspended particles including phytoplankton, zooplankton, and bacteria from the water column. Moreover, some bivalves can also feed via pedal-feeding, which is the uptake of organic matter from the sediment using cilia on the foot. Diplodon parallelopipedon is a native bivalve from South America, which can obtain their foo
Structural maintenance of chromosome (SMC) complexes organize and regulate genomes via DNA loop extrusion. During this process, the complexes increase the loop size by reeling in DNA from one or both sides of the loop. The factors governing this symmetry remain unclear. Here, we combine single-molecule analysis and molecular dynamic simulations to investigate the symmetry of loop extrusion of vari
Background: Nutri-Score is a scientifically validated 5-color front-of-pack nutrition label reflecting the nutrient profile of foods. It has been implemented in several European countries on a voluntary basis, pending the revision of the European labeling regulation. Hence, scientific evidence is needed regarding the ability of the nutrient profile underlying the Nutri-Score (uNS-NPS, 2023-updated
A naturalistic view should make us appreciate the rich possibilities of nature. This naturalistic point of departure, as formulated by Willem B. Drees, invites reflection on the relationship between nature and spirituality. Today, the concept of sustainability occupies a key role in what has come to be the greatest challenge ever that humankind has faced together at the same moment in history. Usu
Background: Beta-cell monogenic forms of diabetes have strong support for precision medicine. We systematically analyzed evidence for precision treatments for GCK-related hyperglycemia, HNF1A-, HNF4A- and HNF1B-diabetes, and mitochondrial diabetes (MD) due to m.3243 A > G variant, 6q24-transient neonatal diabetes mellitus (TND) and SLC19A2-diabetes. Methods: The search of PubMed, MEDLINE, and Emba
