Filtyp
Objective: Professional operatic singing is vocally demanding, making the maintenance of professional vocal health a paramount concern for the opera chorister. Occupational environment has been shown to affect vocal health for other vocally dependent professions. Hence, the objective of the current study was to explore what occupational environment factors affect the professional vocal health of S
Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque
Hematopoietic stem cell (HSC) transplantation offers a cure for a variety of blood disorders, predominantly affecting the elderly; however, its application, especially in this demographic, is limited by treatment toxicity. In response, we employ a murine transplantation model based on low-intensity conditioning protocols using antibody-mediated HSC depletion. While aging presents a significant bar
Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort (n = 173; 86 full twin pairs, 1 singleton), including comprehensive measurements of obesity-related outcomes, mitochondrial DNA quantity and nuclear DNA methyla
About 4.4% of the global emissions of greenhouse gases can be ascribed to healthcare. Intensive care is among the most resource intensive specialties and the purpose of this study was to quantify the total climate impact of a Swedish intensive care unit (ICU) and identify modifiable elements that can lower the intensive care unit’s climate impact. A process-based life cycle assessment was conducte
Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an
Airborne wear particle emissions from dry clutches have been investigated in terms of particle mass and number concentration, size distribution, and chemical composition of a single clutch material. This paper presents a detailed continuation of the investigation. Clutch plates of two different friction materials, i.e., from different manufacturers but for the same automobile applications, are tes
We present the concept of our new high power laser facility Attohallen in Gothenburg, with focus on its first high-order harmonic generation beam line. The key specifications of this facility, including the architecture and operation of the femtosecond drive laser system, the XUV generation part of its first beam line for photon-demanding attosecond timing experiments in the energy range up to abo
Particle exchange heat engines are a novel class of cyclic heat engines that are all-electrical, contain no moving parts and can therefore be scaled down to nanometer size. At the center of their operation is the manipulation of a particle flow between a hot and a cold reservoir through energy filtering mechanisms, where their efficiency depends primarily on the sharpness of the energy filter. In
Background & aims: Colorectal cancer (CRC), particularly rectal cancer, often requires neoadjuvant radiotherapy (RT) as part of its treatment plan. Although effective, RT can cause significant gastrointestinal side effects. Because the onset of RT-induced tissue injury can be anticipated, there is an opportunity to apply preventive measures before the damage occurs. This study aimed to assess
To contribute to the development of effective support for early career researchers during and after doctoral education, the aim of this study was to examine the experiences of the early career transition after affiliation with an interdisciplinary graduate school, using the Swedish National Graduate School on Ageing and Health (SWEAH) as an example. Through qualitative interviews with 18 alumni, t
Bivalves are considered mainly filter-feeding organisms; they remove suspended particles including phytoplankton, zooplankton, and bacteria from the water column. Moreover, some bivalves can also feed via pedal-feeding, which is the uptake of organic matter from the sediment using cilia on the foot. Diplodon parallelopipedon is a native bivalve from South America, which can obtain their foo
When Sweden adopted its carbon tax in 1990, it was as one of the first of its kind worldwide. While the adoption of the tax has been attributed to its inclusion in the Swedish tax reform, undoubtedly playing a crucial role, the reform does not in itself explain how the Swedish carbon tax came about or why it became part of the reform package in the first place. In this article, we present a case s
Background: Prolactin receptor (PRLR) signaling affects breastfeeding and potentially breast cancer treatment response. Methods: The prognostic impact of 20 PRLR single nucleotide polymorphisms (SNPs) in relation to adjuvant treatment groups in patients with primary breast cancer (n = 1701, 2002–2016, Sweden) was evaluated. Genomic DNA was genotyped on Illumina OncoArray, and survival analyses wit
Purpose of review Myocardial infarction survivors are at a high risk of a recurrent event despite receiving guideline preventive therapy. There is accumulated evidence that persistent atherosclerotic plaque inflammation contributes to this risk. Oxidized low-density lipoprotein (LDL) is widely recognized as a key factor in plaque inflammation and instability; however, no therapies that directly ta
The rising prevalence of type 2 diabetes among migrant populations from low- and middle-income countries (LMICs) living in high-income countries (HICs) presents a significant public health challenge. Migrants often experience lifestyle changes, socioeconomic disadvantages and barriers to accessing healthcare, which can increase their risk for type 2 diabetes. This review explores the prevention an
Aims: The objective of this study was to compare the risk of developing type 1 diabetes in individuals with celiac disease, hyperthyroidism and hypothyroidism to that of individuals without those conditions. Materials and Methods: In this retrospective, observational, matched-cohort study based on real-world claims data, individuals with at least one diagnosis of celiac disease, hyperthyroidism (e
Individuals with immigrant background generally perform less well in school than non-immigrants. Performing well in school may decrease the risk of substance use disorder (SUD). We investigated whether higher school performance is associated with a decreased risk of SUD in early adulthood among immigrants and non-immigrants and whether subsequent educational attainment and employment status partly
AIMS/HYPOTHESIS: The incidence of type 1 diabetes increased during the pandemic in various countries. SARS-CoV-2 infections may trigger the development of type 1 diabetes, but the evidence is inconclusive. This study aimed to assess trends in type 1 diabetes incidence between 2007 and 2023, and to quantify the association between SARS-CoV-2 infections and the risk for developing type 1 diabetes.ME
The atomic lattice plays a critical role in the emergence of high-𝑇𝑐 superconductivity in cuprates. While the dynamics associated with electron-lattice coupling typically unfold on picosecond-to-femtosecond timescales, we present an x-ray photon correlation spectroscopy investigation on an optimally doped La-based cuprate that reveals a strong response of kilosecond-scale lattice relaxation dyna
