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By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to
Background: Although case-control studies have identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer, the clinical role of these SNPs remains unclear. Objective: Evaluate previously identified SNPs for association with prostate cancer and accuracy in predicting prostate cancer in a large prospective population-based cohort of unscreened men. Design, setting, an
Natural enemies such as predatory arthropods and parasitoids have the potential to suppress pest species and provide the ecosystem service biological control. When predicting the potential of biological control in agriculture it is important to give evidence on how agricultural management influence the abundance and functions of the natural enemies. In this study we examined whether managements pr
Background: We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line. Methods: RBM3 mRNA
The focus of my thesis has been the Swedish lay judges. My purpose has been to examine the Swedish system of lay judges and furthermore study it in relation to legal certainty. My major problem statement has been: In accordance with legal certainty, what advantages and disadvantages can be seen with the system of lay judges? The Swedish lay judges participate primarily in district and appellate c
Denna uppsats handlar om den delen av kvinnorörelsens historia där kvinnors rätt till högre statstjänster berörs. I takt med industrialiseringen förändrades det svenska samhället och medförde att kvinnor tog plats på arbetsmarknaden på ett helt annat sätt än tidigare. Sedan mitten av 1800-talet var kvinnor aktiva på den statliga arbetsmarknaden och fick tillträde till universitetsstudier i början This essay is about the part of the history of the women's movement where women's right to higher civil service is affected. In time as the industrialization happened, Swedish society changed which resulted in that women took their place in the labor market in a completely different way than before. Since the middle of the 19th century, women were active in the state labor market and gaine
The nomadic pastoralists of the Sahel are often identified as a group at the frontline of global climate change. Their existence in arid and semi-arid regions and their reliance on seasonal rainfall are among the factors that contribute to their vulnerability to drought and climate shocks. This study focuses on risks to pastoralists in Sudan, asking whether index-based livestock insurance, an inno
Insect pollination, despite its potential to contribute substantially to crop production, is not an integrated part of agronomic planning. A major reason for this are knowledge gaps in the contribution of pollinators to yield, which partly result from difficulties in determining area-based estimates of yield effects from insect pollination under field conditions. We have experimentally manipulated
The species richness of flower-visiting insects has declined in past decades, raising concerns that the ecosystem service they provide by pollinating crops and wild plants is threatened. The relative commonness of different species with shared ecological traits can play a pervasive role in determining ecosystem functioning, but information on changes in abundances of pollinators over time is lacki
Majoriteten av världens extremt fattiga bor i rurala områden och 300 miljoner av dem i Indien och Kina. Trots att länderna kommit en bit på vägen i sin strukturella omvandling arbetar fortfarande runt hälften av befolkningen på landsbygden inom jordbruket. De direkta och indirekta effekterna som den primära sektorn skapar har visat sig viktiga av olika anledningar. Hur detta kommer sig undersöks n
Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called ‘long COVID’, are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total o
Objective: To assess the association between education and all-cause and cause-specific mortality among patients with osteoarthritis (OA) in comparison to an OA-free reference cohort.Methods: Using data from the Skåne healthcare register, we identified all residents aged ≥45 years in the region of Skåne, with doctor-diagnosed OA of peripheral joints between 1998 and 2013 (n=123,993). We created an
PurposeTo validate a candidate instrument, to be used by different professionals to assess image quality in digital mammography (DM), against detection performance results.MethodsA receiver operating characteristics (ROC) study was conducted to assess the detection performance in DM images with four different image quality levels due to different quality issues. Fourteen expert breast radiologists
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic variation in cord blood and body composition in the offspring. Genome-wide DNA methylation was analyzed in cord blood from 208 offspring from the Treatment of Obese P
Purpose: To further understand social and leisure (SL) participation after stroke and how it can be supported in a long-term perspective, this study aims to deepen the understanding of strategies used by long-term stroke survivors in relation to SL activities. Materials and methods: The study has a qualitative design, using a grounded theory approach, and is based on in-depth interviews with 10 pe
We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N
The colloidal stability of lipid based cubosomes, aqueous dispersion of inverse bicontinuous cubic phase, can be significantly increased by a stabilizer. The most commonly used stabilizers are non-ionic tri-block copolymers, poloxamers, which adsorb at the lipid-water interface and hence sterically stabilize the dispersion. One of the challenges with these synthetic polymers is the effect on the i
After having emerged as primary contenders in the race for highly efficient optoelectronics materials, organolead halide perovskites (OHLP) are now being investigated in the nanoscale regime as promising building blocks with unique properties. For example, unlike their bulk counterpart, quantum dots of OHLP are brightly luminescent, owing to large exciton binding energies that cannot be rationaliz
Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generat
