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Brain organoid technology has seen significant development in recent years. This self-organized, three-dimensional, organ-oriented brain tissue model can recapitulate the process of neurogenesis and consists of diverse cell types and cellular architecture. Transplanting brain organoids in vivo could be a potential tool from bench to clinical research and has been studied for many purposes. To inve

Background: Graft rejection (GR) is common complication after haploidentical hematopoietic cell transplantation (haplo-HCT). There are only a few studies describing the clinical presentation and potential risk factors of GR, and the optimal rescue strategy is not established. Objectives: To evaluate the cumulative incidence and potential risk factors for GR following haplo-HCT, and to compare surv

BACKGROUND: The cross-sectional association between cerebral tissue oxygen saturation (SctO 2) and heart failure (HF) has been previously studied, but the prognostic significance of SctO 2 in HF remains uncertain. This study aimed to assess the role of SctO 2 as a risk factor for all-cause mortality and rehospitalisation, as well as to explore the cross-sectional association between physical ac

Stem cell sources capable of producing appropriate cells for replacement will be necessary for functional repair of the injured brain. Here, we have determined whether transcription factor programming of human embryonic stem (hES) cells can be used to generate layer-specific cortical neurons capable of integrating into the stroke-injured rat cortex. Human embryonic stem cells were programmed via o

Direct reprogramming of somatic cells into induced neurons (iNs) has become an attractive strategy for the generation of patient-specific neurons for disease modeling and regenerative neuroscience. To this end, adult human dermal fibroblasts (hDFs) present one of the most relevant cell sources. However, iNs generated from adult hDFs using two-dimensional cultures are difficult to maintain in vitro

Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit

We use a closed-loop algorithm to accurately program hafnium zirconium oxide (HZO) ferroelectric tunnel junctions (FTJs) to arbitrary chosen target conductance values. The key enabler is suppression of conductance growth. We have identified two different mechanisms contributing to the total conductance of FTJs. By controlling both, we demonstrated an up to threefold increase of the usable conducta

The transition to smart, wearable, and flexible optoelectronic devices that communicate with each other and perform neuromorphic computing at the edge, is a major goal in next-generation optoelectronics. These devices are expected to carry out their regular tasks while being supported by energy-efficient, in-memory computations. In this study, a lateral flexible device based on cesium lead tribrom

Purpose: To examine the association between uncomplicated urinary tract infections and subsequent type 2 diabetes (T2D) diagnosis in women. Materials and methods: We included 1,840,044 women without previously diagnosed type 2 diabetes (T2D) or redeemed antidiabetic drugs. Results and conclusions: During the 12-year study period, women with uncomplicated urinary tract infections (cystitis and pyel

A memlumor is an innovative neuromorphic luminescent device with a state-dependent photoluminescence quantum yield (PLQY) designed for optical neuromorphic computing applications. Metal halide perovskite memlumors leverage charge trapping and photodoping to modulate the PLQY, making it dependent on the excitation light history. Here, we demonstrate the ability of perovskite memlumors to classify t

High-performance X-ray detectors are essential for 3D X-ray imaging in computed tomography (CT), but conventional systems require high radiation doses to achieve fine resolution. All-In-One (AIO) Cu(I) halide complexes, capable of forming both ionic and coordinate bonds within a single structure, offer efficient scintillation at lower doses, yet their performance remains limited by nonradiative en

Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,

The expansion of the electric vehicle industry is driving increased demand for lithium-ion batteries (LIBs), which in turn creates challenges in material availability and waste management that more durable LIBs could address. Electrode surface coating helps extend LIB lifespan, with atomic layered deposition (ALD) as the preferred method due to its precise thickness control and ability to coat var

The dispersion-scan technique (d-scan) is a well-established technique for the measurement of ultrashort laser pulses. While a single-shot version of d-scan is relatively easy to implement for sub-10 fs laser pulses, this becomes increasingly difficult as the pulse duration increases due to the need for a larger dispersion range, which scales quadratically with the Fourier transform limit (FTL). H

Insulin resistance (IR) contributes to atherogenic dyslipidemia and elevated ASCVD risk. Apolipoprotein A1 (ApoA1)-associated lipoproteins have diverse anti-atherogenic functions, but it is unclear whether IR drives adverse changes in their proteomic composition. We hypothesized that IR is associated with an atherogenic ApoA1 proteome and that insulin-sensitizing interventions would improve its co

Photonic topological insulators and self-induced nonreciprocity based on nonlinear effects in asymmetric structures have garnered increased attention due to their potential applications in quantum information technologies and advanced photonic integrated circuits. In this study, we combine these two fields and present asymmetric photonic crystal designs based on all-dielectric checkerboard structu

Depiction of sinusoidal displacement in nanocrystal superlattices through a minimum of geometric shapes and contrasting colors. This cover pays homage to the Bauhaus movement, celebrating human-made craftsmanship, clarity, and accessibility in scientific design, and remains faithful to its fundamental principle: less is more.

2023 JCP Emerging Investigators Special Collection: Tuning perovskite nanocrystal superlattices for superradiance in the presence of disorder

Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st