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Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-independent manner. The molecular basis of this process is, however, not understood. Here, we studied the low complexity linker between the N- and C-terminal doma
System co-sensitization and extension of the π-conjugated system are recognized as two key strategies for improving the performance of dye-sensitized solar cells (DSSCs). In this study, density functional theory (DFT) was employed to simulate two experimentally synthesized molecules, RK1 and D205, and to evaluate the performance of their co-sensitization system. Furthermore, molecular design was c
The striped p × √3 reconstruction of Au(111) is a textbook example of how electrode surfaces reorganise in response to an applied potential. Using in situ high-energy surface X-ray diffraction, we track the surface reconstruction in 0.1 M HClO4electrolyte while the potential is cycled at both 5 mV s−1and 2 mV s−1between 0.06 V and 0.86 V versus RHE. Reciprocal-space maps, collected every ∼10 s, sh
Photo-induced dynamics of electronic processes are driven by the coupling between electronic and nuclear degrees of freedom. Here, we construct one- and two-dimensional organic-inorganic tin halides to investigate how dimensionality controls exciton-phonon coupling and exciton self-trapping. The results show that a one-dimensional system has strong exciton-phonon coupling leading to excitation-ind
The Aβ42 peptide (APP(672–713)), associated with Alzheimer disease, is highly prone to form amyloid fibrils and has been extensively studied through in vitro experiments. Such experiments represent a basis for understanding the biophysical chemistry of amyloid-related diseases. In this communication, we show that homogeneous primary nucleation in vitro of Aβ42 fibrils is a very rare event, implyin
Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her
Interfacial structures on the nanoscale are crucial for a wide field of applications ranging from biological membranes in life sciences through organic solar cells and industrial coatings in soft matter to hard matter structures. The latter include thin film coatings and materials such as magnetic nanoparticles and topological structures like magnetic skyrmions. Advancing such application rests on
A major challenge hampering the industrial and biological exploitation of lipases is the self-limiting effect of the lipolytic reaction. Defying sustained attention throughout history, the influence of lipase catalysed lipolysis on the internal structure of thin triglyceride films has proved elusive. An in-depth understanding of the lipolysis process at the triglycerides/aqueous interface will ass
Changes in plant diversity and abundance due to land-use modifications can induce plant-pollinator trophic cascades, potentially leading to long-term shifts in pollination services. Our ability to mediate such loss of pollination services through informed landscape management is limited by insufficient understanding of long-term adaptations of wild pollinators to land-use, especially when accounti
With organic solar cells surpassing 20% efficiency, the focus is shifting toward understanding the more complex mechanisms in ternary blends. This work investigates the distinct working principles of ternary organic solar cells based on a polymer donor (D) and a nonfullerene acceptor (NFA), with a fullerene acceptor (FA) as the third component. A systematic comparison between ternary D:NFA:FA syst
Context: Organic farming aims to make agriculture more sustainable, but its sustainability benefits may be offset by lower yields compared to conventional farming. Avenues to increase organic yields have been studied extensively, but there is a lack of research using integrated approaches that consider co-variation between different organic management practices within commercial farming systems. M
BACKGROUND AND AIMS: Guideline-directed medical therapy (GDMT) for heart failure (HF) is underutilized in primary care, particularly among older adults with chronic stable HF. This prospective quality improvement study, Heart Failure in Southern Sweden (HISS), evaluated the impact of a cross-disciplinary implementation project combining cardiology and primary care expertise to enhance GDMT adheren
Background Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition influenced by both genetic and environmental factors. Prenatal and perinatal exposures have been implicated in ASD etiology, but their influence may vary across clinical subgroups, including subgroups defined by co-occurring intellectual disability (ID). Methods We conducted a population-based case–control st
Recent advances in vibrational spectroscopy techniques have proven to be reliable, fast and operator-independent tools for extracellular vesicles (EVs) study. In an attempt to further reveal the wide potential that the vibrational spectroscopy can achieve in EV characterization, in the present study we analysed the EVs isolated from various cell lines employing Attenuated Total Reflectance Fourier
Titel: Spel på planen och i redovisningen Seminariedatum: 2026-01-14 Kurs: FEKH69, Examensarbete i redovisning på kandidatnivå, 15 HP Författare: Elias Haglund, Calle Johansson Lundqvist, Zebastian Öhlund Handledare: Johan Dergård Nyckelord: Profit and sustainability rules; Redovisningseffekter; Beteendeeffekter; Reglering Forskningsfrågor: Hur har PSR påverkat Premier League klubbarnas externa Title: Play on the pitch and in the accounts Seminar date: 2026-01-14 Course: FEKH69, Bachelor degree project in Accounting, undergraduate Level, 15 ECTS-Credits Authors: Elias Haglund, Calle Johansson Lundqvist, Zebastian Öhlund Advisor: Johan Dergård Key words: Profit and sustainability rules; Accounting effects; Behavioral effects; Regulations Research questions: How has PSR affected Premier Le
Oligomers are transient toxic species in amyloidoses such as Alzheimer's disease. The binding of oligomers by human chaperone proteins has been inferred from the lack of detectable interactions with monomeric amyloid proteins and delay of fibril formation at sub-stoichiometric chaperone to monomer molar ratios. In this study, we provide direct experimental evidence for the binding of the human cha
Microsoft Word - Crisis4 - Quality Visibility in CEO Response.docx 4TH INTERNATIONAL CONFERENCE ON CRISIS COMMUNICATION IN THE 21ST CENTURY OCTOBER 7 – 10, 2015 IN HELSINGBORG, SWEDEN Quality Visibility in CEO Response: Connecting to Authenticity Following a Crisis Chigo Ugoalah 404 – 1139 W. Broadway Vancouver, BC V6H 1G1 Royal Roads University, cugoalah@gmail.com Abstract
https://www.isk.lu.se/sites/isk.lu.se/files/chigo_ugoalah.pdf - 2026-07-23
