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Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better
Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has been found to result in inefficient erythropoiesis because of deregulated coordination of cell cycle exit and mitochondrial biogenesis. However, the pathophysiology remains to be fully described, and further chara
AIMS: We aimed to search for associations between cognitive test results with mortality and rehospitalization in a Swedish prospective heart failure (HF) patient cohort.METHODS AND RESULTS: Two hundred and eighty-one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making T
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individual
Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with card
Despite progress in use of decellularized lung scaffolds in ex vivo lung bioengineering schemes, including use of gels and other materials derived from the scaffolds, the detailed composition and functional role of extracellular matrix (ECM) proteoglycans (PGs) and their glycosaminoglycan (GAG) chains remaining in decellularized lungs, is poorly understood. Using a commonly utilized detergent-base
Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approa
BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen
Objectives: . SLE is an autoimmune disease with increased cardiovascular morbidity and platelet activation. In the general population, increased platelet size predicts platelet reactivity and cardiovascular disease. The aim of this study was to investigate whether platelet size related to platelet activation and cardiovascular disease in SLE.Methods: . Fresh blood samples from SLE patients ( n = 1
The intricate balance between dopaminergic and cholinergic neurotransmission in the striatum has been thoroughly difficult to characterize. It was initially described as a seesaw with a competing function of dopamine versus acetylcholine. Recent technical advances however, have brought this view into question suggesting that the two systems work rather in concert with the cholinergic interneurons
Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms
Irregular dietary intakes impairs estimations from food records. Biomarkers and method combinations can be used to improve estimates. Our aim was to examine reproducibility from two assessment methods, compare them, and validate intakes against objective biomarkers. We used the Malmö Offspring Study (55% women, 18-71 y) with data from a 4-day food record (4DFR) and a short food frequency questionn
Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a
Brevmall Postadress Sölvegatan 37, 223 62 Lund Hämtställe 50 Besöksadress Ekologihuset, Sölvegatan 37 Telefon 046-222 0000 Fax 046-222 4206 E-post Centrum för mi l jö- och k l imat forskn ing Plan för jämställdhet, likabehandling och mångfald för Centrum för miljö- och klimatforskning Jämställdhets och likabehandlingsplan 2015-2016 Antagen av CEC styrelse 2015-05-06. Introduktion Centrum för miljö
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/jamstalldhetsplan_2015-2016.pdf - 2026-07-19
NGEM01_Master_thesis_Felix_Martin_Hofmann Student thesis series INES nr Glacial history of the upper Drac Blanc catchment (Écrins massif, French Alps) Felix Martin Hofmann 2018 Department of Physical Geography and Ecosystem Science Lund University Sölvegatan 12 S-223 62 Lund Sweden Felix Martin Hofmann (2018). Glacial history of the upper Drac Blanc catchment (Écrins massif, French Alps) Glaciatio
https://www.nateko.lu.se/sites/nateko.lu.se/files/ngem01_master_thesis_felix_martin_hofmann_1.pdf - 2026-07-19
LUNDS UNIVERSITET 2015-02-17 Socialhögskolan Weddig Runquist Om undersökningens bakgrund och problemformulering samt syfte och frågeställningar I alla undersökningar oavsett vetenskaplig ambitionsnivå är det viktigt att dels identifiera vad det är för forskningsproblem som studien skall behandla, dels formulera undersökningens syf- te och forskningsfrågor. För många studenter kan det vara svårt at
https://www.soch.lu.se/sites/soch.lu.se/files/skrift_om_problemformulering_150217.pdf - 2026-07-19
Rättighetslistan – Lunds universitets studenters rättigheter och ansvar Sida 1 av 21 Rektor BESLUT Diarienummer STYR 2022/1347 Datum 2024-01-18 Rättighetslistan – Lunds universitets studenters rättigheter och ansvar Fastställd av rektor 2024-01-18 Rättighetslistan – Lunds universitets studenters rättigheter och ansvar, nedan Rättighetslistan, är beslutad av rektor och ska fungera som stöd för stud
Termin 1-6: Grundterminer (180 hp)Grundnivån fungerar som en sammanhållen grundläggande juridisk utbildning. Efter fullgjorda studier på grundnivå finns det möjlighet att ta ut en kandidatexamen i rättsvetenskap om 180 högskolepoäng. Termin 1: Introduktion till juridiken, allmän rättslära och konstitutionell rätt - 30 hp Denna kurs är uppdelad i tre delkurser:Delkursen Introduktion till juridiken
https://www.jur.lu.se/utbildning/juristprogrammet/programstruktur - 2026-07-17
Civ ilingenjörsutbildning i lantmäteri: utbildningsplan Civ ilingenjörsutbildning i lantmäteri Programkod: TALAN Omfattning: 300 högskolepoäng Tillträdesnivå: Grundnivå Beslutsfattare: Programledning L Utbildningsplanens giltighet: 2020/2021 Utbildningsplanen fastställd: 2019-12-11 Förutom utbildningsplanen för denna utbildning gäller även ge- mensamma föreskrifter och information för LTH. 1 Syfte
https://www.student.lth.se/fileadmin/lth/utbildning/studiehandboken/20_21/L_Uplan_20-21.pdf - 2026-07-18
