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Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. T
Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t
Som ett led i regeringsuppdraget att ”Utvidga kunskapen om barns läkemedel och deras användning” anordnade Läkemedelsverket 2012 ett möte med representanter för barn- och ungdomspsykiatrin. Syftet var att identifiera kunskapsluckor samt föreslå speciella läkemedelsområden där det fanns behov av att sammanställa kunskap. Behandling av sömnstörningar hos barn var ett område som priori
BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A t
Geokronologi och paleomagnetiska studier är de viktigaste verktygen för paleogeografiska rekonstruktioner kring hur kontinenter fårhållit sig relativt till varandra under geologisk tid. Genom att jämföra s.k. polvandringskurvor och tidpunkter för storskaliga magmatiska händelser mellan olika krustala block (kontienter/kratoner) kan vi få en bättre förståelse av hur dessa block förhöll sig relativtRobust geochronology and well-constrained paleopoles are the main tools for paleogeographic reconstructions. Through the completion of so called barcode diagrams (matching of coeval events of mafic magmatism between blocks) and determination of the apparent polar wander paths, these studies provide a better understanding of the position of continents and supercontinents in the past. The robust U–P
In scholarly literature, it is widely acknowledged that ‘the shadow of hierarchy’, hence the threat of disadvantageous Community legislation, is an important con-cept in European social dialogue (ESD), where European social partners – that is organised labour and management – are given the chance to negotiate binding agreements on some aspects of European labour and social policy. While the shadow
The Purpose of this study was to examine how family law secretaries describe children's participation in custody, housing and contact investigations before and after the implementation of the Convention on the Rights of the Child. The results are analyzed by two theories, the room for maneuver for the bureaucrat at street level by Michael Lipsky and the participation model by Roger Hart. The e
Begreppet ”produkt” definieras i art. 2 i rådets direktiv 85/374/EEG av den 25 juli 1985 om tillnärmning av medlemsstaternas lagar och andra författningar om skadeståndsansvar för produkter med säkerhetsbrister som varje lös sak. Även om det inte uttryckligen framgår av bestämmelsen, har det tolkats som att innebörden av lösa saker begränsas till fysiska föremål. Med nya digitala framsteg och i daAccording to Art. 2 of the Directive 85/374/EEC, a “product” includes all movables. Although not explicitly stated, it has been interpreted that intangible products are excluded from the ambit of the Directive. With new progress within the digital field and in today’s information society, software is replacing many of the functionalities of more traditional products. There has been more than thirt
När en kvinna föder barn kan hon få skador i underlivet. Det kan göra att man senare behöver opereras för att t.ex. tarmen eller urinblåsan inte sitter helt fast på sin ursprungliga plats i magen utan istället buktar ut i slidan, något som kallas för framfall. Ca 7000 kvinnor opereras för sådana problem varje år i Sverige och det blir en stor kostnad för samhället. Även om man kan få framfall utanBACKGROUND: It is well-known that pelvic organ prolapses and perineal tears can be a consequence of vaginal birth. Seven thousand women undergo surgery for pelvic organ prolapses in Sweden every year. OBJECTIVE: To search for medical literature that describes the identification and repair of the anatomical structures present in obstetrical perineal tears. To make an attempt to understand how prola
A search for the resonant production of a heavy scalar X decaying into a Higgs boson and a new lighter scalar S, through the process X → S(→bb¯)H(→γγ), where the two photons are consistent with the Higgs boson decay, is performed. The search is conducted using an integrated luminosity of 140 fb−1 of proton-proton collision data at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector
Preclinical studies suggest that taurine may exert neuroprotective effects. However, its relevance to dementia risk in human populations remains unclear. We investigated the associations between mid-life dietary taurine intake, circulating taurine concentrations, and the risk of late-life all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in a large prospective cohort. This
Risk and vulnerability assessments are an important part of the Swedish disaster management system and can be used as input for decision making. Today disaster management decisions are made on all levels in Sweden depending on the extent of the decisions. The purpose of this thesis has been to perform a descriptive study of how risk and vulnerability assessments are utilised as input to decision m
This qualitative case-study highlights the importance of the phenomenon of migration, under the aspect of civic activism of migrants, and its impact on Italian agricultural sustainable development. Migrants are too often seen as a burden rather than active agents of development. The present research investigates how political activism of migrants develops and eventually affects the sustainable dev
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early
Collagen VII is an essential anchoring protein in the basement membrane zone, maintaining the attachment of stratified and pseudostratified epithelia to the underlying interstitial matrix. However, collagen VII is largely unexplored in normal lungs and idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive accumulation of extracellular matrix (ECM) and aberrant re-epithelializat
High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale
Aims Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative
The future role of boreal forests in the global carbon cycle is uncertain given the rapid climate change in high latitudes. At the landscape scale, heterogeneity in stand age and land cover, contributions from terrestrial and aquatic fluxes, and harvest export may create complex carbon cycle-climate interactions. However, the integrated response of the net landscape carbon balance (NLCB) to inter-
Deposition of phosphorus (P) is important for the nutrient supply to forests and open land but also contributes to the eutrophication of surface waters. Deposition to open land can be measured as bulk deposition while deposition to forests cannot be measured directly, due to internal circulation of P within forest canopies. This study aimed to quantify the total deposition of P to open land and fo
