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Alzheimer's disease is a neurodegenerative condition which involves heavy neuronal cell death linked to oligomers formed during the aggregation process of the amyloid β peptide 42 (Aβ42). The aggregation of Aβ42 involves both primary and secondary nucleation. Secondary nucleation dominates the generation of oligomers and involves the formation of new aggregates from monomers on catalytic fibril su
Bimetallic nanoparticles have gained significant attention in catalysis as potential alternatives to expensive catalysts based on noble metals. In this study, we investigate the compositional tuning of Pd–Cu bimetallic nanoparticles using a physical synthesis method called spark ablation. By utilizing pure and alloyed electrodes in different configurations, we demonstrate the ability to tailor the
This article presents a search for new resonances decaying into a Z or W boson and a 125 GeV Higgs boson h, and it targets the νν¯ bb¯ , ℓ+ℓ−bb¯ , or ℓ±νbb¯ final states, where ℓ = e or μ, in proton-proton collisions at s = 13 TeV. The data used correspond to a total integrated luminosity of 139 fb−1 collected by the ATLAS detector during Run 2 of the LHC at CERN. The search is conducted by examin
Aims Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative
The future role of boreal forests in the global carbon cycle is uncertain given the rapid climate change in high latitudes. At the landscape scale, heterogeneity in stand age and land cover, contributions from terrestrial and aquatic fluxes, and harvest export may create complex carbon cycle-climate interactions. However, the integrated response of the net landscape carbon balance (NLCB) to inter-
Deposition of phosphorus (P) is important for the nutrient supply to forests and open land but also contributes to the eutrophication of surface waters. Deposition to open land can be measured as bulk deposition while deposition to forests cannot be measured directly, due to internal circulation of P within forest canopies. This study aimed to quantify the total deposition of P to open land and fo
AimPeak oxygen uptake (VO2peak) is closely related to total heart volume (THV) in healthy individuals. This study aimed to investigate 1) the association between VO2peak and THV in subjects with subclinical diastolic dysfunction, athletes, healthy controls, and patients with established heart failure with and without preserved ejection fraction (HFpEF, HFrEF), and 2) whether VO2peak/THV-index can
Preclinical studies suggest that taurine may exert neuroprotective effects. However, its relevance to dementia risk in human populations remains unclear. We investigated the associations between mid-life dietary taurine intake, circulating taurine concentrations, and the risk of late-life all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in a large prospective cohort. This
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective
Background and Purpose Plaque rupture is the underlying cause of most cardiovascular events, such as stroke and myocardial infarction. The co-stimulatory molecule LIGHT (tumor necrosis factor superfamily member 14, TNFSF14) has been detected in foam cell-rich regions of atherosclerotic plaques, but whether it has a role in plaque stability is not known. This study investigates the association betw
Background: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) wit
The keystone species concept holds that certain members of an ecological community, despite their low abundance, exert disproportionately large effects on species diversity and composition. In microbial ecology, experimental validation of this concept has been limited because targeted removal of individual species remains technically challenging. Here, we developed a procedure to test the keystone
Effective environmental policies for the tropics depend on accurate, representative scientific data. However, there is strong evidence from particular disciplines and regions that existing research is patchily distributed. Here, we show that poor representation of sampling and citation in some biomes and across key environmental gradients from all disciplines for the entire tropics may lead to fla
Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of
Atomic layer deposition (ALD) of HfOx layers has emerged as a promising strategy for interface passivation in chalcopyrite-based thin-film solar cells. However, the nucleation dynamics of (Ag,Cu)(In,Ga)Se2 (ACIGS) absorbers remain insufficiently understood, particularly regarding the interplay between absorber composition and alkali postdeposition treatments (PDTs). Here, we employ in situ ambient
Objective: To investigate cellular immune responses to the herpes zoster (HZ) subunit (HZ/su) vaccine in patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKis). Methods: RA patients treated with JAKi (n=46) at the Department of Rheumatology, Skåne University Hospital, Sweden, and healthy controls (n=37) received two doses of the HZ/su vaccine. Blood samples were colle
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Ungdomsarbetslösheten bland unga under 25 år är sedan 1990-talet en stor utmaning. Detta samtidigt som övergången från skola till arbetsliv utgör en nyckeldimension vad gäller ungdomsarbetslöshet. En faktor som avgör denna övergång handlar om matchningen mellan gymnasial utbildning samt efterfrågade kunskaper på arbetsmarknaden. Sverige har en heterogen matchning, ungdomsarbetslösheten är hög, sam
