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A mutant lacking the ability to express the surface-exposed lipoprotein protein D was constructed by linker insertion and deletion mutagenesis of a cloned DNA insert containing the protein D structural gene from a nontypeable Haemophilus influenzae strain (NTHi). An isogenic NTHi mutant was isolated after transformation of genetically competent bacteria. The transformant was unreactive to a protei
Based on high-resolution (R approximate to 42 000 to 48 000) and high signal-to-noise (S/N approximate to 50 to 150) spectra obtained with UVES/VLT, we present detailed elemental abundances (O, Na, Mg, Al, Si, Ca, Ti, Cr, Fe, Ni, Zn, Y, and Ba) and stellar ages for 12 new microlensed dwarf and subgiant stars in the Galactic bulge. Including previous microlensing events, the sample of homogeneously
Background: Physiotherapy research concerning interventions for children with CP is often focused on collecting evidence of the superiority of particular therapeutic methods or treatment modalities. Articulating and documenting the use of theory, instrumentation and research design and the assumptions underlying physiotherapy research interventions are important. Physiotherapy interventions focusi
Background: Excessive use of antibiotics is worldwide the most important reason for development of antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious impact on all countries. Initiative
Certain religious organisations restrict their operations to a specific geographical area despite the fact that their aim presumably would be to transcend these boundaries. They promote one overarching religious identity that is shared worldwide which is why it should not be in the organisations interests to limit themselves geographically. The study’s objective is therefore to comprehend how the
Veldfires occur as seasonal events in South Africa. During veldfires, the relationship between the fire actors and the affected population is important to the crisis communication. In the Dr. Kenneth Kaunda District Municipality there are primarily three fire actors: the fire brigade, the Fire Protection Association (FPA) and Working on Fire (WoF). The aim of the study is to explore the communicat
Unilateral coercive measures are a foreign policy tool that are thousands of years old and used by states in response to foreign policy concerns. Their use has become more common throughout the 21st Century, and this raises concerns from a human rights perspective. The purpose of this thesis is to demonstrate that unilateral coercive measures exacerbate suffering and add additional human rights vi
Observationer visar på ständigt stigande temperaturer och modellerade data pekar på fortsatta temperaturökningar för framtiden. Förändringar i klimatet kommer påverka ekosystem och därmed de tjänster vi får ifrån dem. I Sverige är skogen ett av de viktigaste ekosystemen för oss människor. Skogen är av största vikt för Sveriges ekonomi. I dagsläget förekommer flera olika skador på svensk skog årligClimate observations are showing that air temperatures are constantly increasing, and modelled data indicates that temperatures will continue rising in the future. Changes in the climate will affect ecosystems and consequentially, the ecosystem services we depend upon. In Sweden, forests are among the most important ecosystems for humans. The forest is a major part of the Swedish economy. Currentl
In 2000, the Clinton Administration in the U.S. adopted the Commodity Futures Modernization Act, which deregulated the U.S. trade with financial instruments on commodity markets. With respect to this adoption, it has been regarded as one catalyst for the Global food crisis 2008, where millions of individuals lacked provision and access to agricultural products and nutrition. From the perspective o
Aims: To assess the effect of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) with contemporary drug-eluting stents on the composite of cardiac death or myocardial infarction (MI) vs. medical therapy in patients with stable coronary lesions. Methods and results: We performed a systematic review and meta-analysis of individual patient data (IPD) of the three available
This paper summarises a comprehensive Monte Carlo simulation study for precision resonance energy scan measurements. Apart from the proof of principle for natural width and line shape measurements of very narrow resonances with PANDA, the achievable sensitivities are quantified for the concrete example of the charmonium-like X(3872) state discussed to be exotic, and for a larger parameter space of
Introduction: Community Case Management (CCM) aims to improve health outcomes among children under five with malaria, diarrhea, and pneumonia, but its effectiveness in Malawi is limited by inconsistent standards of delivery characteristic of paper-based interventions. This may lead to negative impacts on child health outcomes and inefficient use of health system resources. This study evaluated the
Searches for dijet resonances with sub-TeV masses using the ATLAS detector at the Large Hadron Collider can be statistically limited by the bandwidth available to inclusive single-jet triggers, whose data-collection rates at low transverse momentum are much lower than the rate from standard model multijet production. This Letter describes a new search for dijet resonances where this limitation is
År 1960 upptäcktes Cesium-137-aktivitet från atmosfäriska kärnvapenprovvid mätningar på lågaktivitets laboratoriet iLund. Denna händelse initierade mätningar av den svenska samiska befolkningen och iprodukter från ren som betar i de svenska fjällen. En semi-bärbarhelkropps detektor konstruerades med en detektionsgräns för 137Cs som var tillräckligt bra för att mäta människor med högakroppskoncentrIn 1960 Caesium-137 activity from atmospheric nuclear weapons test was dis-covered in measurements at the whole body gamma-ray counting laboratory inLund. This event initiated measurements of the Swedish Sami population, and inproducts from reindeer that bite lichens in the Swedish mountains. A semi-portable whole-body counter designed with a detection limit for 137 Cs at high radiation background
Genome wide DNA alterations were evaluated by array CGH in addition to RNA expression profiling in colorectal cancer from patients with excellent and poor survival following primary operations. DNA was used for CGH in BAC and cDNA arrays. Global RNA expression was determined by 44K arrays. DNA and RNA from tumor and normal colon were used from cancer patients grouped according to death, survival o
Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration of cytostatics necessitating development of smart local drug delivery systems. To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone drug used for osteosarcoma treatment, shows reversible accretion to hydroxyapatite (HA) of both nano (nHA) and micro (mHA) size. nHA particles
BACKGROUND: Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC).METHODS: Patient cohorts from two different HIPEC-centers underwent cytoreductive surgery and HIPEC with Oxaliplatin (39 patients) and MMC (56 patients), respectively. They were compared for toxicity and survival data. The ext
A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb-1 of proton-proton collisions at s=13 TeV recorded with the ATLAS detector. The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ+τ-decay with at least one τ-lepton decaying into final states with hadrons. The data are in good agreement
Background: The pathological response to preoperative chemotherapy of colorectal liver metastases (CRLMs) is predictive of long-term prognosis after liver resection. Accurate preoperative assessment of chemotherapy response could enable treatment optimization. Purpose: To investigate whether changes in lesion-apparent diffusion coefficient (ADC) measured with diffusion-weighted magnetic resonance
