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BACKGROUND: HYPO-RT-PC is a phase 3 trial comparing ultra-hypofractionated and conventionally fractionated radiotherapy in intermediate-to-high-risk localised prostate cancer. This 10-year update reports long-term efficacy and toxicity outcomes.METHODS: In this open-label, randomised, phase 3, non-inferiority trial done in ten centres in Sweden and two in Denmark, we recruited men aged 75 years or

Brevmall Postal address Box 117, 221 00 Lund Visiting address Sandgatan 3, Hus R Gamla Kirurgen Telephone +46 46 222 48 35 switchboard +46 46 222 00 00 Fax +46 46 222 44 11 Email helen.wiman@sam.lu.se Website www.sam.lu.se/en Facul ty Board Regulations for third cycle education at the Faculty of Social Sciences 1 GENERAL PROVISIONS GOVERNING RESEARCH STUDIES .......................................

https://www.sam.lu.se/en/internal/sites/sam.lu.se.en.internal/files/regulations-for-third-cycle-education-faculty-of-social-sciences.pdf - 2026-05-30

IMPORTANCE: The clinical utility of stress cardiovascular magnetic resonance imaging (CMR) in stable chest pain is still debated, and the low-risk period for adverse cardiovascular (CV) events after a negative test result is unknown.OBJECTIVE: To provide contemporary quantitative data synthesis of the diagnostic accuracy and prognostic value of stress CMR in stable chest pain.DATA SOURCES: PubMed

Background: Exposure and Response Prevention (ERP) is a form of behavioural therapy for tics; however, its effectiveness remains uncertain. We aimed to evaluate the effectiveness of internet-delivered, therapist-supported, and parent-assisted ERP for treatment of tics in children and young people with Tourette syndrome or chronic tic disorder. Methods: This multicentre, parallel group, single-blin

Background: The apolipoprotein E (APOE) ε4 allele is associated with higher cholesterol levels, and an increased risk of developing Alzheimer’s disease (AD) and amyloid-related imaging abnormalities after initiation of amyloid-modifying therapies. A worse cognitive response to cholinesterase inhibitor (ChEI) treatment and longitudinal outcome in APOE ε4-carriers has been observed. Based on these c

Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functiona

Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample

Abstract Background: Advanced paediatric surgery is increasingly centralised in Sweden in order to improve treatment outcomes and reduce surgical risks. However, the overall need for surgery in the paediatric population has not been estimated, and the association between geographic access to surgical facilities and timely treatment for common surgical conditions in children is largely unknown.

IMPORTANCE The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. OBJECTIVES To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer history and mutation location. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of 6036 BRCA1 and

Hjärtsvikt betecknar ett syndrom som innebär att hjärtat har otillräcklig förmåga att försörja kroppen med blod. Detta kan antingen bero på att hjärtat inte kan fyllas med eller stöta ut tillräckligt med mängd blod. Patienter med hjärtsvikt har i allmänhet hög dödlighet, detta trots att stora framsteg har gjorts avseende behandlingen av hjärtsvikt, speciellt sedan 1980-talet. Femårsöverlevnaden föIntroduction: Despite major advances, the incidence rate and mortality of heart failure (HF) remains high, with a five-year survival of approximately 50%. At the time of inception of this thesis the familial risks of HF, including the aspects of mortality, were largely underdetermined. This thesis is composed of four papers with the main aims as follows:To determine the risk of hospitalization of

Barnobesitas är sedan flera år ett ökat hälsoproblem bland barn. Obesitas vid 4 års ålder ger en kraftigt ökad risk för obesitas senare i livet. Att förebygga uppkomst och utveckling av obesitas är en långsiktig investering för framtiden. Idag finns ingen evidensbaserad metod för vägledning inom barnhälsovården för att främja hälsosamma levnadsvanor och förebygga obesitas hos förskolebarn. Det övePrevention of childhood obesity with its effects on children’s mental and physical health and well-being is an international public health priority and is suggested to be effective when started early. As Child Health Services lack an evidence-based model, there is the need for development of a low-intensive health promotion model that is feasible and cost-effective in preventing obesity in prescho

Background Influenza and other respiratory viruses promote Streptococcus pneumoniae proliferation in the upper respiratory tract. We sought to investigate for what we believe is the first time, the effect of intranasal live attenuated influenza vaccine (LAIV) on nasopharyngeal S pneumoniae density in a low-income to middle-income country population with high pneumococcal carriage rates. Methods I

Background and objectives: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there is limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. Study I aimed to investigate whether there are coherent changes in CSF inflammation associated with central sensitization (CS), and to evaluate po

Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Metho

The doubly magic nucleus ¹⁰⁰Sn represents a crucial test for the nuclear shell model, which is a widely used model for a quantitative description of nuclei. Excited states in ¹⁰⁰Sn are experimentally not accessible with present day techniques, but it is possible to gain insight into its structure by studying the properties of excited states of neighboring nuclei. These nuclei

Frågan om bevisning utgör en viktig fråga även i skiljeförfaranden. I synnerhet skriftlig bevisning är viktig då den överlag anses vara mer tillförlitlig än muntlig sådan. Det är därför av vikt att part får tillgång till all skriftlig bevisning, även sådan som motpart eller annan kan tänkas inneha. Om dessa dokument frivilligt företes av part eller tredje man uppstår inga problem. Problemen börjar

Barsebäcks kärnkraftverk driftsattes 1975 och den första reaktorn togs ur drift 1999 och den andra 2005. Nedmontering och rivning av kärnkraftverket har inletts och processen beräknas vara klar på 2030-talet. Syftet med detta examensarbete är att kartlägga eventuell radioaktiv kontamination i området runt Barsebäcksverket. Mitt mål är att ta fram en metod för att särskilja bakgrundsstrålning från Background and aim: The Barsebäck nuclear power plant (NPP) units ceased operations in 1999 and 2005. Now the NPP is in the phase of decommissioning, which is a complicated process that will take many years to complete. Radiological characterization of the surrounding area is a part of the decommissioning process. The aim of this thesis was to identify and quantify residual anthropogenic radioacti

Chemical Loping Combustion (CLC) is a novel combustion technology in which the exhaust gas is inherently divided into oxygen depleted air in one stream and CO2 and water vapour in another. This is however under the ideal condition that the fuel conversion is complete, i.e. all the hydrocarbons in the fuel is transformed to heat, water vapour and CO2. The CO2 capture rate can under such ideal condi

Ändtarmscancer är en av de vanligast förekommande cancersjukdomarna. Tillsammans med tjocktarmscancer är det den tredje vanligaste cancersjukdomen i världen. Den behandlas vanligen med kirurgi, under vilken en stor del av ändtarmen och dess omgivande fettvävnad tas bort. För att minska risken för återfall kan operationen kompletteras med strålbehandling, där patienterna oftast strålbehandlas innanBackground and purpose: During radiotherapy, rectal cancer patients show inter-fractional internal motion that effects the delivered dose distribution. The purpose of this work is to study I) the inter-fractional bladder volume change, II) the effect of bladder volume change on bowel dose distribution, III) the effect of bladder optimization on the relationship between bladder volume and bowel dos