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Intronic single-nucleotide polymorphisms (SNPs) in FOXO3A are associated with human longevity. Currently, it is unclear how these SNPs alter FOXO3A functionality and human physiology, thereby influencing lifespan. Here, we identify a primate-specific FOXO3A transcriptional isoform, FOXO3A-Short (FOXO3A-S), encoding a major longevity-associated SNP, rs9400239 (C or T), within its 5′ untranslated re

Background: Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that αSyn can exacerbate tau aggregation, implying that αSyn co-pathology may specifically contribute to the Aβ-induced aggregation of tau that drives neurodegeneration and cognitive decline in AD. To in

AIMS: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking.METHODS AND RESULTS: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness

Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse epigenetic aging in humans is unknown. Here, we performed a powerful meta-analysis of the methylome and transcriptome of an unprecedented number of h

Background The health of people with functional variation in Sweden is worse than people without functional variation. A health-promoting resource in adults’ lives is meaningful employment, and for people with functional variation it means some form of daily activity. The project "Grow with horsepower" is a person-centered and nature-oriented daily activity for people with function variation, who

The circulation is a closed system that has been assumed to be free from bacteria, but evidence for the existence of a low-density blood microbiota is accumulating. The present study aimed to map the blood microbiota of outpatients with Crohn’s disease (CD) or with ulcerative colitis (UC) by 16S metagenomics. A diverse microbiota was observed in the blood samples. Regardless of the type of disease

Abstract: Intraspecific color variation is often associated with camouflage or protection, but melanin-based color variation is also linked to behavioral and physiological aspects including boldness. In the melanin-based plumage color polymorphic tawny owl (Strix aluco), the grey morph is known to be more cryptic than the brown morph. Using 19 captive tawny owls (11 grey and 8 brown), we tested if

BACKGROUND: Mosaic loss of chromosome Y (LOY) is associated with cardiovascular and neurodegenerative diseases in men, and genetic predisposition to LOY is associated with poor poststroke outcome. We, therefore, tested the hypothesis that LOY itself is associated with functional outcome after ischemic stroke. METHODS: The study comprised male patients with ischemic stroke from the cohort studies S

Aim: This study aimed to investigate if younger age at diagnosis of colorectal cancer was associated with a diagnostic delay. The secondary objective was to evaluate if symptomatology varied with age. Method: The study population consisted of the cohorts from two prospective multicentre studies conducted in Sweden and Denmark, the QoLiRECT and QoLiCOL studies. These studies investigated the qualit

Collagen VII is an essential anchoring protein in the basement membrane zone, maintaining the attachment of stratified and pseudostratified epithelia to the underlying interstitial matrix. However, collagen VII is largely unexplored in normal lungs and idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive accumulation of extracellular matrix (ECM) and aberrant re-epithelializat

The aim of this study was to investigate torso cooling benefit of various PCM vests in a simulated warm environment (Ta= 34 °C, RH=56 %, Va=0.4 m/s). A pre-wetted cotton torso fabric skin was used to simulate sweating on a thermal manikin (Tmanikin=34 °C). Six conditions were tested: nude fabric skin (Fabric Skin), Vest A without (VA) and with frozen gels with a melting temperature (Tm) of 0 °C (V

WNT/β-catenin signaling is essential for colon cancer development and progression. WNT5A (ligand of non-canonical WNT signaling) and its mimicking peptide Foxy5 impair β-catenin signaling in colon cancer cells via unknown mechanisms. Therefore, we investigated whether and how WNT5A signaling affects two promoters of β-catenin signaling: the LGR5 receptor and its ligand RSPO3, as well as β-catenin

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https://www.wings.lu.se/sites/www.wings.lu.se/files/wings_2013_fritsches.pdf - 2026-07-24

Popular Abstract in Swedish Ortnamn utgör en särskild del av kulturarvet; under århundraden har de muntligen traderats från generation till generation på den plats där de skapats, där de minner om tidigare händelser, aktiviteter och kunskaper. I synnerhet på de håll skriftlig dokumentation är relativt sentida ger ortnamn en möjlighet att nå insikter om den mer avlägsna historien. Detta gäller särs

Internet Metaphors and Norms. To what extent is digital “openness” also creating a modern “Panopticon”? I.e. to what extent is the conceptual imaginary of relevance for the legitimacy of modern data practices in terms of privacy? This paper argues that conceptual battles around what the Internet is and the digital development means are significant battles. The metaphorical descriptions of the inte