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Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eota
AimsThe main objective of this study was to estimate the occurrence of diabetic nephropathy in a population-based cohort of patients diagnosed with diabetes as young adults (15-34years). MethodsAll 794 patients registered 1987-1988 in the Diabetes Incidence Study in Sweden (DISS) were invited to a follow-up study 15-19years after diagnosis, and 468 (58%) participated. Analysis of islet antibodies
In conventional MIMO, propagation conditions are often considered wide-sense stationary over the entire antenna array. In massive MIMO systems, where arrays can span over large physical dimensions, the situation is quite different. For instance, significant variations in signal strength, due to shadowing, can be experienced across a large array. These effects vary with propagation environment in w
Supported Iridium pincer complexes were used to study gas-phase isopropanol dehydrogenation under continuous flow system at temperatures 200-260 °C with different flow rates. First supported catalyst was [Ir(C2H4)(p-tBu2PO-tBu4POCOP)] supported by covalent bonding to silica, the second one was [Ir(HCl)(p-HO2C- tBu4POCOP)] supported by adsorption to γ-Alumina. The highest activity of catalyst 1 w
Background: Warehouses serve an important role in many supply chains as they can affect business competitiveness in terms of both costs and customer service. However, the cost of operating a warehouse is often high due to the presence of many non-value adding activities. Lean is a philosophy that can be used to eliminate waste and enable cost reductions in companies. By implementing Lean warehousi
The integration of Artificial Intelligence (AI) within product development has emerged as a significant area of research, especially in 2022-2023. However, there is a lack of empirical research on how AI tools are integrated into the product development process, especially within the ideation stage of startups, and what challenges and opportunities arise from this integration. Our thesis explores
This study examines the burgeoning patterns of the phenomenon of new-build gentrification. This phenomenon reflects a social justice imbalance, where affluence takes precedence over equitable access and the interests of economically vulnerable groups, in shaping urban spaces. While economic and environmental sustainability have been prioritized in urbanization goals, the social dimensions, includi
This thesis aims at analysing and discussing the rules and opportunities of using permanent establishment within financial structures. Financing structures between related parties can be seen as one of the most common tax planning tools for MNE´s. This planning is tackled by thin capitalization rules and is also under the observation of the transfer pricing guidelines. Whereas permanent establishm
Paediatric B-cell precursor acute lymphoblastic leukaemias (BCP ALL) with IKZF1 deletions (∆IKZF1) are associated with a poor outcome. However, there are conflicting data as to whether ∆IKZF1 is an independent risk factor if minimal residual disease (MRD) and other copy number alterations also are taken into account. We investigated 334 paediatric BCP ALL, diagnosed 1992-2013 and treated according
