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Blood culture diagnostics - a comparative and experimental study on the impact of delayed incubation

ObjectivesThis study investigates the impact of transitioning from restricted to 24/7 access to blood culture cabinets on blood culture processing.MethodA post-hoc retrospective study and a prospective laboratory simulation to evaluate the effects of delayed incubation were conducted. Data analysis evaluated clinical data comparing incubation-to-detection (ITD) and Collection-to-detection (CTD) in

Efficacy of the Web-Based Swedish Individualized Active Communication Education (I-ACE) Program in First-Time Hearing Aid Users : Randomized Controlled Trial

Background: Hearing loss is estimated to affect more than 20% of the global population. Hearing aid fitting is a common intervention in audiological rehabilitation; however, there are still those who struggle with remaining communication difficulties that require additional intervention. The group rehabilitation program Active Communication Education (ACE) has been shown to be an effective alterna

Time to suicide after psychiatric inpatient discharge : a nationwide Swedish survival analysis

BACKGROUND: The period immediately following psychiatric inpatient care is recognized as a time of elevated risk of suicide, yet little is known about factors that influence how soon suicide occurs after discharge.AIM: To examine the timing of suicide among persons after psychiatric discharge and identify sociodemographic and clinical factors associated with a shorter time to death by suicide.METH

Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

Background: Accurately quantifying the risk of osteoporotic fracture is important for directing appropriate clinical interventions. While skeletal measures such as heel quantitative speed of sound (SOS) and dual-energy X-ray absorptiometry bone mineral density are able to predict the risk of osteoporotic fracture, the utility of such measurements is subject to the availability of equipment and hum

IRON NOF trial : IV iron for anaemic patients with femoral fracture

BACKGROUND: Preoperative anaemia is associated with increased use of blood transfusions, a greater risk of postoperative complications, and patient morbidity. The IRON NOF trial aimed to investigate whether the administration of i.v. iron in anaemic patients during hip fracture surgery reduced the need for blood transfusion and improved patient outcomes.METHODS: This phase III double-blind, random

Antimicrobial use at the end of life : a retrospective cohort study

Antibiotic resistance poses a global threat. Antibiotics are administered to 80-90% of terminally ill patients but evidence of their effectiveness in improving survival or symptom relief at the end of life (EOL) is scarce. To determine the proportion of deceased patients that continue antibiotic treatment after documented EOL discussion and the decision to prioritise symptom relief over active tre

Prospective study of patients with immune checkpoint inhibitor-induced hepatitis; characterization of liver injury, outcome of therapy, and management of steroid-unresponsive and steroid-dependent hepatitis

BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre

2018-03-14 general radiation safety manual for work at pet-spect lbic

Lund University Bioimaging Center General Radiation Safety Rules for work in PET/SPECT/CT facility BMC A09 Prepared by: Marie Sydoff Approved by: Freddy Ståhlberg Counter-signed by: Ritha Gidlöf Latest updated: 2018-03-12 Valid from: 2018-03-12 1 GENERAL For the safety of everyone who will be working with radiation in the PET/SPECT/CT unit in BMC A09, the following rules have to be strictly follow

https://www.lbic.lu.se/sites/lbic.lu.se/files/2018-03-14_general_radiation_safety_manual_for_work_at_pet-spect_lbic.pdf - 2026-05-25

Planning Primates - A search for episodic foresight

Popular Abstract in Swedish Förmågan att planera med en medveten mental simulering har ansetts vara unikt mänsklig sedan Aristoteles. När människor planerar för psykologiska eller fysiologiska driftstillstånd som de för närvarande inte upplever, tror man att de använder sig av så kallad episodisk framförhållning. Den episodiska framförhållningen är en del av det större episodiska kognitiva systemeThe ability to plan for future, not currently experienced, mental or physiological states has been regarded as unique to humans. When humans plan for such states it has been hypothesized that they make use of what has been known as episodic foresight. Episodic foresight is a part of the episodic cognitive system, which also includes episodic memory. The defining feature of this system is so-called

Low calcaneal bone mineral density and the risk of distal forearm fracture in women and men: A population-based case-control study.

Objective: We used dual X-ray absorptiometry (DXA) to measure calcaneal bone mineral density (BMD) and estimate the prevalence of osteoporosis in a population with distal forearm fracture and a normative cohort. Methods: Patients 20 to 80 years of age with distal forearm fracture treated at one emergency hospital during two consecutive years were invited to calcaneal BMD measurement; 270 women (81

Parity, weight change, and maternal risk of cardiovascular events

Background High parity has been suggested to increase risk of maternal cardiovascular disease independent of body mass index measured after childbearing. Pregnancy is, however, associated with persistent weight gain and metabolic changes that, independent of parity, increase the risk of cardiovascular disease. It could therefore be questioned if high parity independently increases the risk of card

Fall-related activity avoidance in relation to a history of falls or near falls, fear of falling and disease severity in people with Parkinson's disease

Background: There is limited knowledge concerning fall-related activity avoidance in people with Parkinson's disease (PD); such knowledge would be of importance for the development of more efficient PD-care and rehabilitation. This study aimed to examine how fall-related activity avoidance relates to a history of self-reported falls/near falls and fear of falling (FOF) as well as to disease severi

Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson's disease

Progressive supranuclear palsy and Parkinson's disease have distinct underlying neuropathology, but both diseases affect cognitive function in addition to causing a movement disorder. They impair response inhibition and may lead to impulsivity, which can occur even in the presence of profound akinesia and rigidity. The current study examined the mechanisms of cognitive impairments underlying disin

Prediction of manifest Huntington's disease with clinical and imaging measures : a prospective observational study

BACKGROUND: Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and predicting conversion to manifest Huntington's disease.METHODS: In this prospective observa

The effectiveness of suggestive techniques in reducing postoperative side effects : A meta-analysis of randomized controlled trials

BACKGROUND: Suggestive interventions such as hypnosis and therapeutic suggestions are frequently used to alleviate surgical side effects; however, the effectiveness of therapeutic suggestion intervention has not yet been systematically evaluated. In the present study, we tested the hypotheses that (1) suggestive interventions are useful for reducing postoperative side effects; (2) therapeutic sugg

Preterm birth and risk of type 1 and type 2 diabetes : a national cohort study

Aims/hypothesis: Preterm birth (gestational age <37 weeks) has been associated with insulin resistance early in life. However, no large population-based studies have examined risks of type 1 and type 2 diabetes and potential sex-specific differences from childhood into adulthood. Clinicians will increasingly encounter adults who were born prematurely and will need to understand their long-term ris

Low levels of soluble TWEAK, indicating on-going inflammation, were associated with depression in type 1 diabetes : a cross-sectional study

Background: Low levels of the soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) and depression are linked to cardiovascular disease. Galectin-3, inadequate glycemic control and low high-density lipoprotein (HDL)-cholesterol levels were previously linked to depression in these patients with type 1 diabetes mellitus (T1DM). The main aim was to explore whether sTWEAK was associat

Integrated bio-chemostratigraphy of Lower and Middle Triassic marine successions at Spiti in the Indian Himalaya : Implications for the Early Triassic nutrient crisis

In this paper we study the Lilang Super Group in the Spiti area, Indian Himalaya to understand environmental changes in the aftermath of the end-Permian mass extinction. We focus on the Mikin and Kaga Formations, which span the Induan to Ladinian stages of the Lower and Middle Triassic. These strata formed on the southern mid-palaeolatitude margin of East Gondwana and are interpreted as condensed,

Emissions of biogenic volatile organic compounds and subsequent photochemical production of secondary organic aerosol in mesocosm studies of temperate and tropical plant species

Silver birch (Betula pendula) and three Southeast Asian tropical plant species (Ficus cyathistipula, Ficus benjamina and Caryota millis) from the pantropical fig and palm genera were grown in a purpose-built and environmentcontrolled whole-tree chamber. The volatile organic compounds emitted from these trees were characterised and fed into a linked photochemical reaction chamber where they underwe