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The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution are largely unknown. Using multiomics profiling, we here demons

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L

We performed the largest genome-wide meta-analysis (GWAMA) (Max N=26,494) of the levels of 184 cardiovascular-related plasma protein levels to date and reported 592 independent loci (pQTL) associated with the level of at least one protein (1308 significant associations, median 6 per protein). We estimated that only between 8-37% of testable pQTL overlap with established expression quantitative tra

Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects wi

The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Preclinical research relies on xenograft mouse models, but these models preclude the human-specific functional interactions of stem cells with their bone marrow microenvir

Background: Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis. Methods: Study participants (n = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes. A coronary artery calcium score (CACS) > 0 defi

Denna avhandling presenterar utvecklingen och studiet av en flexibel och kiselchip-kompatibel integration av III–V nanotrådsbaserade (NW) optoelektroniska komponenter i nätverkskretsar, där kommunikation sker genom utsändning av ljussignaler. Detta innefattar en undersökning av hur neurala bearbetningsbeteenden kan efterliknas med hjälp av fotoniska kretsar på chip. Både experimentella resultat soThis thesis presents the development and study of a flexible and Silicon-chip compatible integration of III–V nanowire (NW) optoelectronic components in network circuits, where communication is done via the broadcasting of light signals. This includes an investigation into how neural processing behaviours can be emulated using on-chip photonic circuits. Both experimental works that demonstrate the

Sammanfattning Problembeskrivning Konfektionsbranschen har problem med osålda produkter vilket resulterar i hög kapitalbindning. Modesvängningarna inom konfektionsbranschen blir allt snabbare vilket gör att felinköp av stora produktpartier kan bli avgörande för företagets lönsamhet. Produkter som inte säljs i ordinarie butiker måste avyttras och ett alternativ kan vara outletförsäljning. Syfte Syf

Using theory of elasticity it is not possible to describe exactly how a statically indeterminate structure collapses. Theory of elasticity is often combined with an assumption of breakage at a certain level of stress, this meaning that a structure will break as soon as this level of stress is reached in the most heavily loaded section. A plastic hinge will occur followed by a changed distribution

Soft regionalism och regionala identiteter i Storbritannien har sällan blivit utforskade utöver nationella debatter avseende Skottland, England, Wales och Cornwall. Dessutom har även många senare regionala studier i England försummats helt. Denna studie har sin bakgrund i den pågående debatten om decentrialisering (devolution) och skapandet av nya regionala myndigheter och urbaner-regioner i StorbSoft regionalism and regional identities in Great Britain has seldom been explored beyond the national debates of Scotland, Wales, and Cornwall. Many recent local studies in England have, too, been neglected. This study is set against the backdrop of the ongoing debates around devolution within the United Kingdom and the creation of new regional authorities and city-regions. This thesis investigat

Tanken på självkörande bilar har funnits nästan lika länge som det har funnits bilar. Denna uppsats har ämnat utreda vilka rättsekonomiska konsekvenser en skada vållad av ett förarlöst fordon medför samt hur lagstiftningen ur ett de lege ferenda-perspektiv bör vara utformat utifrån rättsekonomiska teorier. Rättsekonomi sträva efter ekonomisk effektivitet. Detta skapar välstånd för individer och väThe idea of self-driving cars has been around almost as long as there have been cars. This thesis investigates the legal consequences of damages caused by a driverless vehicle and how the legislation out of a de lege ferenda-perspective should be, based on legal-economic theories. Law and economics theories strives for economic efficiency. This creates wealth for individuals and welfare in society

Målet med denna studie åir att bestämma tryck och temperatur ftir en del av det Östra Segmentet i Svekonorvegiska Provinsen. Henestad metabasiten består dels av gabbro och dels av metamorf granatamfibolit. Gradvisa övergångar mellan dessa ändled kan observeras över korta avståLnd (dm-m). Stuffer fiån två olika områden togs lor analys. Båda är granatamfiboliter, men W23 har stöme granater (6 mm) ocThis study presents the results of P-T estimation of amphibolite facies rocks in the Eastern Segment of the Sveconorwegian orogen. The investigated Hìrrestad metabasite consists of both unmetamorphosed gabbro and metamorphosed gamlet amphibolite and gradual transitions over a few meters between these end-members. Trio sampl.s *".e collectåd and used in this study._!ample.W23 i¡ an amphibolite

Plankorsningar, där väg och järnväg möts i en punkt, utgör en riskfylld del av transportsystemet. Olyckorna vid plankorsningar har lett till allvarliga konsekvenser i Sverige. Där Sveriges långsiktiga mål (Nollvisionen) syftar på att ingen ska dö eller skadas allvarligt i trafiken, vilket omfattar att öka säkerheten vid plankorsningar för att. Syftet med examensarbete har varit att undersöka säkerLevel crossings, where road and railway intersect at the same point, represent a high-risk part of the transport system. Accidents at level crossings have led to serious consequences in Sweden. Sweden's long-term goal (the Vision Zero) aims for no one to be killed or seriously injured in traffic, which includes increasing safety at level crossings. The purpose of this thesis has been to examin

The reassignment technique is used to increase localization for signal components in the time-frequency representation. The technique gives perfect localization for linear chirp signals and constant frequency signals. Despite the recent interest in using the reassignment technique to determine phase-shifts, no general expression of cross-spectrogram reassignment vectors exists. This submission aim

https://www.kultur.lu.se/fileadmin/user_upload/sol/utbildning/Tentamina/Studentinstruktioner-Zoom-tentamen.pdf - 2026-05-18

https://www.ht.lu.se/fileadmin/user_upload/sol/utbildning/Tentamina/Studentinstruktioner-Zoom-tentamen.pdf - 2026-05-21

https://www.fil.lu.se/fileadmin/user_upload/sol/utbildning/Tentamina/Studentinstruktioner-Zoom-tentamen.pdf - 2026-05-23

HISA28, Historia: Nätbaserad fortsättningskurs 30 hp Beslutad av Historiska institutionens styrelse 2020-12-04, reviderad 2024-05-24 Delkurs 1. Tematisk fördjupningskurs, 7,5 hp Se särskild lista Delkurs 2. Akademiskt skrivande, 7,5 hp Obligatorisk kurslitteratur Betygskriterier i tabellform, Historia 1b, [Elektronisk resurs], Skolverket, Stockholm, 2011 knowledgeReq.pdf (skolverket.se) (2 s.) His

https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISA28/20251/Litt_HISA28.pdf - 2026-05-31

Nyhetsbrev 2018 till dig som deltar i ett världsunikt projekt Det är sjätte gången som Ingrid kommer till GÅS- projektets mottagning i Malmö, och hon har nu hunnit fylla 102 år. Hon har varit med sedan forsk- ningsprojektet började och tycker att det har varit in- tressant att få vara med och hjälpa till med forskning, särskilt eftersom hon själv har blivit äldre. Vissa delar av undersökningen tyc

https://www.geriatrik.lu.se/sites/geriatrik.lu.se/files/nyhetsbrev2018_fin.pdf - 2026-06-01