Sökresultat

Filtyp

Din sökning på "Buy fc coins Buyfc26coins.com is EA Sports official for FC 26 coins A reliable source for buying coins..Svi0" gav 83305 sökträffar

Statement-expert-group HUGE final

Progamme evaluation of PhD education in Service Studies: Statement from external expert group Page 1 of 23 STATEMENT FROM EXTERNAL EXPERT GROUP Reg. No. STYR 2023/22 2023-11-03 Evaluation report for the Department of Human Geography: bachelor and master studies in Human Geography and Urban planning Assignment and composition of the external expert group The expert group consists of two (originally

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2024-05/Statement-expert-group_HUGE_final.pdf - 2026-06-01

Clinical photon-counting CT in living patients detects intraplaque haemorrhage and thrombus in carotid plaques

In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clin

Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis

Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh

Boosting structural food science using X-ray and neutron techniques

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance

The role of natural outdoor environment on COVID-19 mortality and hospitalisations among older community-dwellers in the pre-vaccination period : the Register RELOC-AGE cohort study in Sweden

BACKGROUND: Most COVID-19-related deaths and hospitalisations occurred among older people. Natural outdoor environments influence health outcomes, but the evidence of their effect on COVID-19 outcomes among older adults is limited. This study aimed to investigate associations between residential natural outdoor environment and COVID-19-related deaths or hospitalisations among community dwellers ag

Netquant2 : automated web-based quantification of neutrophil extracellular traps from fluorescence microscopy

Neutrophil extracellular traps (NETs) are structures that neutrophils form in response to various stimuli, including invading pathogens. NETs are increasingly studied, and their importance has been demonstrated in autoimmunity and infection. However, no consensus has emerged on their quantification, with many studies resorting to manually counting NETs in microscopy images. NETQUANT is a free soft

Retraction note : CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling (Nature Cell Biology, (2021), 23, 7, (758-770), 10.1038/s41556-021-00702-0)

Retraction to: Nature Cell Biology23:758-770 https://doi.org/10.1038/s41556-021-00702-0 (2021) The authors have retracted this article because it has come to their attention that numerous errors have been identified in the immunoblotting (western blotting) experiments shown in the main Figures 1c, 3a, 4f, 5b and 6b, and the supplementary Figures 1b, 1c, 2d, 3a, 3c, 7f, 8b and 9b. The authors have

Varus alignment of the hip and knee 2 years after anterior cruciate ligament injury is associated with medial tibiofemoral osteoarthritis 3 years later

Purpose: To investigate if hip and knee alignment assessed 2 years after anterior cruciate ligament (ACL) injury is associated with compartment-specific radiographic knee osteoarthritis (OA) 3 years later. Methods: An exploratory analysis was conducted in the knee ACL, nonsurgical versus surgical treatment (KANON) trial (ISRCTN84752559); 115 subjects with acute ACL injury were assessed at the 2-ye

Evaluation of the Ability of Machine Learning-Models to Assess Postural Orientation Errors During a Single-Leg Squat

OBJECTIVES: To reach agreement among experts on visual assessments of postural orientation errors (POEs) during the single-leg squat (SLS), and to use expert agreement assessments as ground truth for machine learning (ML) models to evaluate their ability to classify POEs.DESIGN: Methodological study with mixed-methods design.METHODS: POEs of the lower extremity and trunk were assessed from videos

The ESCAPER Study - exploring protective mechanisms against cardiovascular disease in subjects at high risk : Rationale, study protocol, and first results

IntroductionThe ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. This suggests underlying protective mechanisms. Initiated in September 2022, this exploratory study aims to uncover and define these mechanisms, potentially leading to nove

Hyltemossa arbetsmiljopolicy

Brevmall Postadress Sölvegatan 37, 223 62 Lund Hämtställe 50 Besöksadress Ekologihuset, Sölvegatan 37 Telefon 046-222 0000 E-post Eivor.Terne@cec.lu.se Centrum för mi l jö- och k l imat forskn ing Arbetsmiljöpolicy och rutiner Hyltemossa mätstation Fastställd av CEC styrelse 2016-11-25. Hyltemossa mätstation är en enhet inom Centrum för miljö- och klimatforskning, CEC vid Lunds universitet. Vid Hy

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/hyltemossa_arbetsmiljopolicy.pdf - 2026-06-01

Comorbidities and mortality in subgroups of adults with diabetes with up to 14 years follow-up : a prospective cohort study in Sweden

Background: Subgroups of adult-onset diabetes, namely severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), and mild obesity-related diabetes (MOD) or mild age-related (MARD) diabetes, have been defined with clinical variables and a machine-learning approach. Our aim was to describe their long-term outcomes and mortality. Methods: In

Impaired SARS-CoV-2 vaccine responsiveness is not associated with subclinical atherosclerosis or cardiovascular disease

AIMS: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking.METHODS AND RESULTS: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness

Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events

AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab

Disruption of CSF-1 receptor-mediated metal ion homeostasis in the murine brain promotes neurodegenerative disease

Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development an

Restoring tumor immunogenicity with dendritic cell reprogramming

Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 3