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Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as t
A French book relating to flea literature has recently been discovered at the National Library of Sweden in Stockholm. This article claims to be the first presentation of the work Histoire d’une puce by Louis Marie Céleste d’Aumont, Duke of Piennes (1762-1831), with the first literary analysis of its erotic content. The second half of the story is remarkable for the presence of Swedish words in th
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder involving scarring of pulmonary tissue and a subsequent decrease in respiratory capacity, ultimately resulting in death. Tartrate resistant acid phosphatase 5 (ACP5) plays a role in IPF but the exact mechanisms are yet to be elucidated. In this study, we have utilized various perturbations of the bleomycin mouse model of IPF includ
The recently developed Phase-Scaled Reassignment (PSR) can estimate phase-difference between two oscillating transient signals with high accuracy. However, in low signal-to-noise ratios (SNRs) the performance of commonly applied reassignment techniques is known to deteriorate. In order to reduce variance in low SNR, we propose a multitaper PSR (mtPSR) method for phase-difference estimation between
Coherence is a useful measure in many engineering applications. Here, we focus on the case where the input signal to a linear system can be measured free from noise, but the output signal is perturbed by noise. A novel expression for the expectation of a multitaper magnitude squared coherence estimate for this case is presented and verified through numerical evaluation. Additionally, the expressio
Time-frequency reassignment, commonly used to analyze time-varying signals, is a post-processing method that sharpens time-frequency representations. However, the reassignment method is sensitive to noise, making it unsuitable for time-frequency analysis when the signal-to-noise ratio is low. To increase the robustness of the reassignment technique, we develop a novel reassigned multitaper spectro
Stem cell therapies for Parkinson's disease are at an exciting time of development, and several clinical trials have recently been initiated. Human pluripotent stem cells are differentiated into transplantable dopamine (DA) progenitors which are proliferative at the time of grafting and undergo terminal differentiation and maturation in vivo. While the progenitors are homogeneous at the time of tr
In the literature, auditory attention is explored through neural speech tracking, primarily entailing modeling and analyzing electroencephalography (EEG) responses to natural speech via linear filtering. Our study takes a novel approach, introducing an enhanced coherence estimation technique to assess the strength of neural speech tracking. This enables effective discrimination between attended an
Introduction: The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. We investigated the relationships between the shedding of CD46 and CD59 into the circulation, reflected by plasma levels of soluble CD46 and CD59, and the risk for post-ACS complications. Methods: We measured plasma sCD46 and sCD59 in a cohort of 546 ACS
A novel method to derive pressure-volume (PV) loops noninvasively from cardiac magnetic resonance images has recently been developed. The aim of this study was to evaluate inter- and intraobserver variability of hemodynamic parameters obtained from noninvasive PV loops in healthy controls, subclinical diastolic dysfunction (SDD), and patients with heart failure with preserved ejection fraction, mi
We report a new design of an acoustophoretic trapping device with significantly increased capacity and throughput, compared to current commercial acoustic trapping systems. Acoustic trapping enables nanoparticle and extracellular vesicle (EV) enrichment without ultracentrifugation. Current commercial acoustic trapping technology uses an acoustic single-node resonance and typically operates at flow
Metal-assisted chemical etching (MACE) is a cheap and scalable method that is commonly used to obtain silicon nano- or microwires but lacks spatial control. Herein, we present a synthesis method for producing vertical and highly periodic silicon microwires, using displacement Talbot lithography before wet etching with MACE. The functionalized periodic silicon microwires show 65% higher PEC perform
Light absorbing carbonaceous aerosols produced from combustion span over a range of physicochemical properties. Soot is the most recognized species in this category and its formation process involves gradual maturation from amorphous young soot with a high hydrogen-to-carbon-ratio toward mature soot aggregates. In this work, the optical response of a single particle soot photometer (SP2) to electr
Objectives: To evaluate a cancer detecting artificial intelligence (AI) algorithm on serial biopsies in patients with prostate cancer on active surveillance (AS). Patients and methods: A total of 180 patients in the Prostate Cancer Research International Active Surveillance (PRIAS) cohort were prospectively monitored using pre-defined criteria. Diagnostic and re-biopsy slides from 2011 to 2020 (n
The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Lis
• We aimed to capture possible insights from an AI diagnosing without human guidance.• We believe the result mainly aligns with previous knowledge. Though, vital signs and sex did not aid the AI diagnostics.
LUDC-IRC Postdoctoral Program 2020 – Project 6 LUDC-IRC Postdoctoral Program 2020 – Project 6 The role of hormone sensitive lipase in brain function PI: Cecilia Holm Co-PI: Joao Duarte Purpose and aims Hypothalamic dysfunction has been suggested to precipitate the development of obesity and metabolic syndrome. On the other hand, complications deriving from unhealthy lifestyles and obesity impact t
https://www.ludc.lu.se/sites/ludc.lu.se/files/holm_project_6.pdf - 2026-05-30
1 European Association for Quality Assurance in Higher Education Standards and Guidelines for Quality Assurance in the European Higher Education Area © European Association for Quality Assurance in Higher Education, 2005, Helsinki Layout: Pikseri Julkaisupalvelut Helsinki, Finland 2005 This project has been funded with support from the European Commission in the framework of the Socrates programme
https://www.staff.lu.se/sites/staff.lu.se/files/050221-enqa-report.pdf - 2026-05-30
