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The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders 1–4, but attempts to assess constraint for non-protein-coding regions have proved more difficult. Here we aggregate, process and release a dataset of 76,156 human genomes from the Genome Aggregation Database (gnomAD)—the larges
Recent studies of selective auditory attention have demonstrated that neural responses recorded with electroencephalogram (EEG) can be decoded to classify the attended talker in everyday multitalker cocktail-party environments. This is generally referred to as the auditory attention decoding (AAD) and could lead to a breakthrough for the next-generation of hearing aids (HAs) to have the ability to
Cell death plays a pivotal role in many physiological processes, such as cell homeostasis, embryonic development, immune defence and in the pathophysiology of numerous diseases, such as cancer, infections and degenerative diseases. However, the lack of a comprehensive and up-to-date resource on cell death regulators poses a significant challenge to researchers in the field. Existing databases are of
Background Exposure to hexavalent chromium (Cr(VI)) can occur during occupational activities and leading lung cancer. MicroRNA (miRNA) plays an important part in carcinogenesis. Whether Cr(VI) exposure causes cancer-related miRNA changes is yet uncharacterized. Methods This study included 89 Cr(VI) exposed workers and 47 controls. MiRNAs were extracted from plasma followed by library preparations,
Purpose: The need for sentinel lymph node biopsy (SLNB) in clinically node-negative (cN0) patients is currently questioned. Our objective was to investigate the cost-effectiveness of a preoperative noninvasive lymph node staging (NILS) model (an artificial neural network model) for predicting pathological nodal status in patients with cN0 breast cancer (BC). Methods: A health-economic decision-ana
Stem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow into the blood. Identifying the genetic factors that control blood CD34+ cell levels could reveal new drug targets for HSPC mobili
Plasma metabolomics holds potential for precision medicine, but limited information is available to compare the performance of such methods across multiple cohorts. We compared plasma metabolite profiles after an overnight fast in 11,309 participants of five population-based Swedish cohorts (50–80 years, 52% women). Metabolite profiles were uniformly generated at a core laboratory (Metabolon Inc.)
Oral assessment is an important method to evaluate the learning outcomes of scientific courses. However,there are certain limitations when oral assessment is applied.One of these limitations, which is not apparent in anonymous written exams, is the existence of biases which could lead to unfair (positive or negative) outcomes of the assessment. This could lead to decreased motivation and sense of
LUDC-IRC Postdoctoral Program 2020 – Project 6 LUDC-IRC Postdoctoral Program 2020 – Project 6 The role of hormone sensitive lipase in brain function PI: Cecilia Holm Co-PI: Joao Duarte Purpose and aims Hypothalamic dysfunction has been suggested to precipitate the development of obesity and metabolic syndrome. On the other hand, complications deriving from unhealthy lifestyles and obesity impact t
https://www.ludc.lu.se/sites/ludc.lu.se/files/holm_project_6.pdf - 2026-05-30
1 European Association for Quality Assurance in Higher Education Standards and Guidelines for Quality Assurance in the European Higher Education Area © European Association for Quality Assurance in Higher Education, 2005, Helsinki Layout: Pikseri Julkaisupalvelut Helsinki, Finland 2005 This project has been funded with support from the European Commission in the framework of the Socrates programme
https://www.staff.lu.se/sites/staff.lu.se/files/050221-enqa-report.pdf - 2026-05-30
1 HT2018 – VT2019 Kursanalys MSFM21 Medicinsk strålningsfysik - sjukhusfysik MSFM21: Bildbehandling och dess matematiska metoder Katarina Sjögreen Gleisner Undervisningsform och examination Den totala kurstiden är 7 veckor. Föreläsningarna på kursen ligger i huvudsak fördelade över kursens första fyra veckor. Dessa varvas med programmeringsövningar, vars syfte är att belysa teorin samt bekräfta oc
https://www.msf.lu.se/sites/msf.lu.se/files/msfm21_medicinsk_stralningsfysik_-_sjukhusfysik_2020-05-11.pdf - 2026-05-30
Title of paper 1 INTRODUCTION Critical infrastructures and societal functions, such as transportation, telecommunications, health care and energy distribution, constitute the backbone of a modern society. These systems are also heavily in- terdependent, meaning that failures in a system does not stay isolated but can cascade to other systems Hence societal resources must be devoted to safe- guard
https://www.cencip.lu.se/sites/cencip.lu.se/files/1160_fullpaper_johansson_et_al_method_cascading_effects.pdf - 2026-05-30
publication_rinne Publications, Janne Rinne January 25, 2021 1 List of publications Summary: 113 papers in peer-reviewed journals, 4 book chapters, 1 lecture material (and revised new edition), 2 articles in professional journals, numerous non-peer-reviewed publications (conference abstracts, reports, etc.) Publications in peer-reviewed journals 113. Cai, Z., S. Junttila, J. Holst, H. Jin, J. Ardö
https://www.nateko.lu.se/sites/nateko.lu.se/files/2021-02/publication_rinne.pdf - 2026-05-30
UTKAST 21 mars- Hållbarhetsredovisning LU 2023 Hållbarhet LUNDS UNIVERSITET Innehåll Lunds universitets hållbarhetsstrategi 3 Övergripande målbilder enligt hållbarhetsstrategin 3 1. Utbildning för hållbar utveckling 4 2. Forskning för hållbar utveckling 5 Starka forskningsmiljöer möter vår tids utmaningar 6 3. Samverkan för hållbar utveckling 7 Innovation för en hållbar framtid 8 Hållbarhetsvecka
RESEARCH IN SERVICE STUDIES LUND UNIVERSITY, Campus Helsingborg Working paper No 5, May 2011 The Department of Service Management The waste hierarchy model: disassembling and reassembling the socio-materiality of waste Johan Hultman and Hervé Corvellec Abstract The production of waste is a central concern for environmental policy, and waste management is a critical urban infrastructural service. T
https://www.ses.lu.se/sites/ses.lu.se/files/oki-wp_5_2011.pdf - 2026-05-30
In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK,
Popular Abstract in Swedish Denna avhandling analyserar frågor som berör tillfälliga jobb på den svenska arbetsmarknaden under perioden 1990-1999. Ett viktigt bidrag i avhandlingen är att den stora gruppen tillfälliga jobb delas upp i mindre undergrupper för att ta i beaktande den heterogenitet som finns mellan olika former av tillfälliga jobb. En röd tråd som löper genom hela avhandlingen är fokuThis thesis analyses different aspects of temporary jobs in the Swedish labour market during 1991-1999. Throughout the thesis we put special focus on differences between the genders, and differences between native-born and foreign-born workers. In chapter 1, An Introduction to Temporary Jobs in Sweden, we describe the evolution of different types of temporary jobs in Sweden during the 1990s, we re
Popular Abstract in SwedishDenna studie utgår från tanken att ett samhälle kan ses som en grupp individer förenade i ett nätverk av sociala relationer. Nyckeln till förståelsen av samhället ligger därför i studiet av dessa sociala nätverk som den praktik (mikronivå) vari de sociala strukturerna (makronivån) reproduceras och förändras.Syftet med studien är att utifrån de sociala nätverken studera hThe aim of the study is to examine, using the social networks as a starting-point, the way a local community is constructed in a specific historical context, namely the industrial community of Limhamn in southern Sweden at the time of the Industrial Revolution 1870-1914. In 1870 the Skånska Cement Company initiated a large-scale extraction of limestone in the area and soon had cement works built i
