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1. Introduktion Utredning Projektering Aktör Förvaltning B D Förstudie Underlag B D Utred. Program System proj. B D Detalj proj. B D Bygg B Över-lämn. Utvärd. mät. D ByggaF, SQUARE, Renobuild Introduktion Detta dokument är resultat från SIRen projektet, WP4: Modeller, metoder och verktyg. Innehållet har tagits fram av: Petter Wallenten, Kristina Mjörnell, Stefan Olander, Karin Farsäter, samt delta
Torrdockans kyrka är ett projekt som undersöker hur kyrkan kan komma närmre människor både fysiskt och mentalt genom kyrkobyggnadens arkitektur. I detta projekt vill jag undersöka relationen mellan teologi, liturgi och arkitektur. Hur påverkar de olika arkitektoniska ställningstaganden teologin och liturgin som ryms i kyrkobyggnaden? Det är ett projekt där jag studerar hur en ny kyrka i en urbaTorrdockan church is a project that investigates how the church through architecture can get closer to human both physically and mentally. In this project I want to investigate the relationship between theology, liturgy and architecture. How do different architectural decision affect the theology and liturgy possibilities in the church building? It is a project where I study how a new church in
I detta arbete utforskar jag hur jag går tillväga att med hjälp av musikteoretiska analyser skriva pastisch i en stil jag inte tidigare har studerat eller har någon djupare kännedom om. Målet har varit att komponera ett stycke i en specifik stil, i det här fallet en musettevals. Kompositionsprocessen i arbetet beskrivs och har sedan sammanfattats i form av en modell som utgör ett generellt tillvägIn this essay I explore how I, using music theoretical analyses, approach writing pastiche in a genre I have never studied before, nor have any deeper knowledge of. The aim has been to compose a piece in a specific genre, in this case a musette waltz. The composing process in the essay is described and has been summarized as a model forming a general approach which could be used when composing a p
Syftet med uppsatsen är att klargöra huruvida analysmodellen medfört några förändringar för revisorn och dess klienter. Empirin har insamlats genom semistrukturerade personliga intervjuer med fyra revisorer och två företagsrepresentanter. Analysen har medfört två betydelsefulla förändringar för revisorns arbete. Det första är dokumentationskravet och det andra är begränsning av konsultverksamhet i
Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly
Background and aims: The aim of the study was to determine potential associations between endothelial dysfunction and arterial stiffness, measured by peripheral arterial tonometry, and coronary artery calcium score (CACS) assessed by computed tomography (CT). Methods and results: The BIG3 study is a prospective longitudinal, non-interventional, pulmonary-cardiovascular cohort study exploring the t
Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterall
Denna rapport redovisar en förstudie till SNS fleråriga forskningsprojekt som undersöker hur värdet av nya läkemedel kan bedömas ur ett brett samhällsperspektiv. En slutsats av förstudien är att det finns goda möjligheter att få bättre svar på många av de policyfrågor som ställs i läkemedelspolitiken, t ex om förskrivning och offentlig subventionering av nya läkemedel. De omfattande svenska patien
Excess dietary salt reduces resting cerebral blood flow (CBF) and vascular reactivity, which can limit the fueling of neuronal metabolism. It is hitherto unknown whether metabolic derangements induced by high-salt-diet (HSD) exposure during adulthood are reversed by reducing salt intake. In this study, male and female mice were fed an HSD from 9 to 16 months of age, followed by a normal-salt diet
Objective Half of all adult emergency department (ED) visits with a complaint of dyspnea involve acute heart failure (AHF), exacerbation of chronic obstructive pulmonary disease (eCOPD), or pneumonia, which are often misdiagnosed. We aimed to create an artificial intelligence (AI) diagnostic decision support tool to detect patients with AHF, eCOPD, and pneumonia among dyspneic adults at the beginn
Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies. Plaques from type 2 diabetes
The receptor for advanced glycation endproducts (RAGE) has pro-inflammatory and pro-atherogenic effects. Low plasma levels of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands, have been associated with increased risk for major adverse coronary events (MACE) in the general population. We performed a genome-wide association study to identify genetic determinants of plasma sRAGE in 4338 indivi
Background: The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA), including comparisons with neurofilament light (NFL) and neuron-specific enolase (NSE). Methods: Retrospective multicentre observational study of patients admitted to an intensive care u
Background: There is an unmet clinical need for novel therapies addressing the residual risk in patients receiving guideline preventive therapy for coronary heart disease. Experimental studies have identified a pro-atherogenic role of the oxidized LDL receptor LOX-1. We investigated the association between circulating soluble LOX-1 (sLOX-1) and the risk for development of myocardial infarction. Me
Despite the glimmer of hope provided by the discovery and commercialization of bone morphogenetic protein-2 (BMP-2) as a bone graft substitute, side effects related to the use of supraphysiological doses have hindered its clinical usage. In this study, we compared the osteoinductive potential of BMP-2 homodimer with a heterodimer of BMP-2/7, both delivered via a collagen-hydroxyapatite (CHA) scaff
