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Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and phy

We study planning problems where the transition function is described by a learned binarized neural network (BNN). Theoretically, we show that feasible planning with a learned BNN model is NP-complete, and present two new constraint programming models of this task as a mathematical optimization problem. Experimentally, we run solvers for constraint programming, weighted partial maximum satisfiabil

Beam line optics for synchrotron facilities are generally designed from geometric calculations wherein the bending magnet, undulator, or wiggler photon source is approximated by a high divergence point source. In this article we will, however, show that in the case of a synchrotron radiation source with very small divergence (such a source can be encountered at an undulator based third generation

We report on the status of efforts to improve the reinterpretation of searches and measurements at the LHC in terms of models for new physics, in the context of the LHC Reinterpretation Forum. We detail current experimental offerings in direct searches for new particles, measurements, technical implementations and Open Data, and provide a set of recommendations for further improving the presentati

As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic fac

Collimated sprays of paticle, known as jets,are abundantly produced in high-energy proton-proton (pp) collisions, and are predicted by many theories of physics beyond the Standard Model. This thesis reports first on the calibration of jets with focus on the data-driven in situ calibration. Two searches for new physics phenomena in events with jets in the final state are then presented. The analyse

Biomarkers are used in molecular biology to predict characteristics of interest and are applied in agriculture to accelerate the breeding of target traits. Proteomics has emerged as a promising technology for improved markers by providing a closer view to the phenotype than conventional genome-based approaches. However, a major challenge for biomarker development is that the identified biological

We study the propagation and diffusion of electric charge fluctuations in the Bjorken hydrodynamic model with both white and Catteneo noise using purely numerical methods. We show that a lattice of noise fluctuations is required to fully calculate the two-point correlators of charge. We introduce a numerical procedure to solve the stochastic differential equations that arise from the charge conser

Building databases are important assets when estimating and planning for national energy savings fromenergy retrofitting. However, databases often lack information on building characteristics needed to determine the feasibility of specific energy conservation measures. In this paper, machine learning methods are used to enrich the Swedish database of Energy Performance Certificates with building c

Prior to the COVID-19 crisis, global air transport demand was expected to triple between 2020 and 2050. The pandemic, which reduced global air travel significantly, provides an opportunity to discuss the scale, distribution and growth of aviation until 2018, also with a view to consider the climate change implications of a return to volume growth. Industry statistics, data provided by supranationa

Several new polydentate and potentially dinucleating ligands have been synthesized in order to model the coordination environments of a number of structurally related dinuclear active sites in metalloenzymes, including methane monooxygenase, the ribonucleotide reductase R2 protein, urease, arginase, red kidney bean purple acid phosphatase and zinc phosphotriesterase.~ Ligands 1 and 2 have proven t

Street-level concentrations of nitrogen dioxide (NO2) and particulate matter (PM) exceed public health standards in many cities, causing increased mortality and morbidity. Concentrations can be reduced by controlling emissions, increasing dispersion, or increasing deposition rates, but little attention has been paid to the latter as a pollution control method. Both NO2 and PM are deposited onto su

Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined. In this study, we have characterized the presence of small surface-associated lipid droplets, distinct from the central droplet, in primary human adipocytes. Base

BACKGROUND: Continuous spike-wave during slow wave sleep syndrome (CSWS) and Landau-Kleffner syndrome (LKS) are two epileptic encephalopathies that present with neurocognitive regression, aphasia, and clinical seizures, typically presenting in children around five years of age. The pathophysiology of these conditions is not completely understood. Some studies suggest a common origin for both. No s

INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infa

As a result of the energy performance of the buildings directive (EPBD 2010), the requirements have been gradually tightened in the Swedish building regulations. For the purpose of the directive to be realized, it is becoming increasingly important to ensure that buildings actually live up to the minimum rules laid down in the Swedish Building Regulations (BBR) or more ambitious requirements impos