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A randomized comparison between league tables and funnel plots as an aid to health care decision-making

Objective Comparison of provider performance is commonly used to inform health care decision-making. Little attention has been paid to how data presentations influence decisions. This study analyzes differences in suggested actions by decision-makers informed by league tables or funnel plots.Design Decision-makers were invited to a survey and randomized to compare hospital performance using either

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system, and changes in GABAergic neurotransmission modulate the activity of neuronal networks. Gephyrin is a scaffold protein responsible for the traffic and synaptic anchoring of GABAA receptors (GABAAR); therefore, changes in gephyrin expression and oligomerization may affect the activity of GABAergic syna

Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report

Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression sever

Making research data possible : negotiating between disciplinary cultures, temporalities, data policies, professional interests and education and training

The workshop brings together differing perspectives on what makes research data possible. How data is made represents an on-going negotiation between a number of elements. It reflects, firstly, the nature of disciplines and thecomplex way this is linked to cultures of research data and data sharing. Secondly, data is made across the complex temporalities within different practices of its managemen

Impact of xylose epimerase on sugar assimilation and sensing in recombinant Saccharomyces cerevisiae carrying different xylose-utilization pathways

BackgroundOver the last decades, many strategies to procure and improve xylose consumption in Saccharomyces cerevisiae have been reported. This includes the introduction of efficient xylose-assimilating enzymes, the improvement of xylose transport, or the alteration of the sugar signaling response. However, different strain backgrounds are often used, making it difficult to determine if the findin

The Family in EU Law

The volume provides a first-ever comprehensive account of the concept and the role of the family in EU law. It explores the family in EU law from four different angles. The first part of the book considers the philosophical and theoretical foundations of the family in the law in general, including the definition of the family under EU law. The second part provides an overview of the rights conferr

On the discovery of new elements (IUPAC/IUPAP Provisional Report) : Provisional Report of the 2017 Joint Working Group of IUPAC and IUPAP

Almost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of

Detailed analysis of health-related quality of life after out-of-hospital cardiac arrest

Aim: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. Methods: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2® (SF-36v2®) at a struc

Survey of non-resuscitation fluids administered during septic shock : a multicenter prospective observational study

BACKGROUND: The indication, composition and timing of administration of non-resuscitation fluid in septic shock have so far received little attention and accordingly the potential to reduce this source of fluid is unknown. The objective of the study was to quantify and characterize non-resuscitation fluid administered to patients with septic shock.METHODS: This prospective observational study was

Assessment and monitoring of reliability and robustness of offshore wind energy converters

The preseni paper provides an overview of existing approaches for design and assessment of offshore structures and on this basis proposes a framework for the risk based assessment and monitoring of the performance of offshore wind energy converters in operation. In recognition of the fact that there are presently no established best practices for the assessment and monitoring of offshore wind ener

Are Beautiful traffic environments safer than Ugly traffic environments?

To link aesthetics to traffic safety, the field of environmental psychology was consid-ered. A new model of driving behaviour was developed, based on Lewin’s (1951) equation, B = f (P,E) and by employing Küllers’ (1991) model of the basic emotional process. The employed model B = f (R(Road), U(Users), A(Task), P(Person)), states that driving behaviour (B) is related to the physical environment (R)

Timing of gazes in child dialogues: a time-course analysis of requests and back channelling in referential communication.

Background: This study investigates gaze behaviour in child dialogues. In earlier studies the authors have investigated the use of requests for clarification and responses in order to study the co-creation of understanding in a referential communication task. By adding eye tracking, this line of research is now expanded to include non-verbal contributions in conversation. Aims: To investigate

On the discovery of new elements (IUPAC/IUPAP Report) : Report of the 2017 Joint Working Group of IUPAC and IUPAP

Almost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of

Utility of G protein-coupled receptor 35 expression for predicting outcome in colon cancer

The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage

Characteristics of two-color holographic recording in lithium niobate doped with thulium

We report ultraviolet-induced transient and stable absorption and two-color holographic recording at 514, 633, and 830 nm in thulium doped stoichiometric LiNbO 3 crystal. The gating light at 355 nm increased the diffraction efficiency and sensitivity. We found the optimum gating-recording intensity ratio for maximum diffraction efficiency and weak nonvolatile holographic storage with gating.

Resilient Food Supply Chains in the Face of the Russo–Ukrainian War: Harnessing the Power of the Internet of Things

The current war in Ukraine has severely disrupted global food supply chains due to the significant decline in the production of grain commodities, of which Ukraine and Russia are major global suppliers. This creates problems in today’s globalised food systems. In particular, a number of countries are heavily dependent on food imports from Ukraine and/or Russia, particularly some developing nations

Ett utile dulci för ungdom : Ungdomens bibliotek som bokserie och förlagssatsning

The Swedish publishing house Svensk läraretidnings förlag published the extensive book series Barnbiblioteket Saga (the Children’s Library Saga) between 1899 and 1970. In this article, the publisher’s less extensive book series Ungdomens bibliotek (the Library of Youth) is analysed as an example of the marketing techniques that the publishing house used to reach different target groups. The articl