Filtyp
Despite the fact that the resolution of conventional contact/proximity lithography can reach feature sizes down to ∼0.5-0.6 micrometers, the accurate control of the linewidth and uniformity becomes already very challenging for gratings with periods in the range of 1-2 μm. This is particularly relevant for the exposure of large areas and wafers thinner than 300 μm. If the wafer or mask surface is n
In this conceptual article, we argue that artificial intelligence (AI) systems are contributing to the generation of an environment of affordances for everyday information practices through which they exert influence on people and the planet in ways that often are left unrecognised. We illustrate our insights by focusing on the practices of information seeking in everyday life, suggesting that the
Background: We studied the association between cardiorenal function and survival, neurological outcome and trends in survival after in-hospital cardiac arrest (IHCA). Methods: We included cases aged ≥ 18 years in the Swedish Cardiopulmonary Resuscitation Registry during 2008 to 2020. The CKD-EPI equation was used to calculate estimated glomerular filtration rate (eGFR). A history of heart failure
Scanning coherent X-ray microscopy (ptychography) has gained considerable interest during the last decade since the performance of this indirect imaging technique does not necessarily rely on the quality of the X-ray optics and, in principle, can achieve highest spatial resolution in X-ray imaging. The method can be easily extended to 3D by adding standard tomographic reconstruction schemes. Howev
BACKGROUND: Calprotectin (S100A8/A9) is a pro-inflammatory mediator primarily released from neutrophils. Previous studies have revealed associations between plasma calprotectin, disease severity and in-hospital mortality in unselected COVID-19 patients.OBJECTIVE: We aimed to assess whether plasma calprotectin dynamics during the first week of intensive care are associated with mortality and functi
Digital breast tomosynthesis (DBT) has become a standard screening tool for breast cancer. However, its diagnostic performance is still limited compared to contrast-enhanced MRI, especially in women with dense breasts. Ultrafast dynamic contrast-enhanced (UF DCE) MRI and diffusion-weighted imaging (DWI) offer a shorter scanning time than conventional MRI and have shown promise in previous studies.
This chapter analyses the role that 'ordre public' and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the chapter will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t
In this work, we exploited time-resolved fluorescence polarization anisotropy (TRFA) to characterize un-doped and doped carbon dots (CDs). The rotational correlation time related to the size of the particle through classical Stokes-Einstein-Debye equation. The TRFA technique applied in this study achieves picoseconds time resolution, which approximately corresponds to the particle size determinati
Background: Driving automation systems (DAS), including autonomous driving and advanced driver assistance, are an important safety-critical domain. DAS often incorporate perceptions systems that use machine learning (ML) to analyze the vehicle environment. Aims: We explore new or differing requirements engineering (RE) topics and challenges that practitioners experience in this domain. Method: We
Objectives: During targeted temperature management after out-of-hospital cardiac arrest infusion of vasoactive drugs is often needed to ensure cerebral perfusion pressure. This study investigated mean arterial pressure after out-of-hospital cardiac arrest and the association with brain injury and long-term cognitive function. Methods: Post-hoc analysis of patients surviving at least 48 hours in th
BACKGROUND: The COVID-19 pandemic has seen many deaths, but the majority were for causes other than COVID-19. However, end-of-life care in all settings has been affected by measures limiting the spread of the virus, for patients with and without COVID-19. The Swedish coronavirus strategy was different compared to many other countries, which might have affected end-of-life care. The aim was to desc
Introduction: Cardiac arrest is characterized depending on location as in-hospital cardiac arrest (IHCA) or out-of-hospital cardiac arrest (OHCA). Strategies for Post Cardiac Arrest Care were developed based on evidence from OHCA. The aim of this study was to compare characteristics and outcomes in patients admitted to intensive care after IHCA and OHCA. Methods: A retrospective multicenter observ
Primary Objective: Traumatic brain injury (TBI) and sports-related concussion (SRC) may result in chronic functional and neuroanatomical changes. We tested the hypothesis that neuroimaging findings (cerebral blood flow (CBF), cortical thickness, and 1H-magnetic resonance (MR) spectroscopy (MRS)) were associated to cognitive function, TBI severity, and sex. Research Design: Eleven controls, 12 athl
To reach a broader understanding of person-environment relationships as building blocks for universal design in research and practice, this paper combine and discuss three types of interaction between individuals and environments - instrumental, non-instrumental, and non-physical - and five constituent concepts, i.e. accessibility, usability, aesthetic experience, the experience of meaning and emo
With the abundance of observations and advancement in modeling, temperate regions allow for a comprehensive comparison of the data-driven and process-based methods of carbon budget estimation. This chapter presents a review of the latest methodologies for carbon budget and component flux estimation, and the key components in the temperate carbon budget, such as forest regrowth, and summarizes unce
Aims/hypothesis: Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods: We conducted a family-based multigenerational study by comparing heterozygous carriers of the HNF1A p.(Gly292fs) variant with the non-carrier
Programmable optical circuits form a key part of quantum technologies today. As the size of such circuits is increased, maintaining precise control over every individual component becomes challenging. Here we show how embedding an optical circuit in the higher-dimensional space of a large mode-mixer allows us to forgo control over individual elements, while retaining a high degree of programmabili
BACKGROUND: Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. Experiences and symptoms vary, and research indicates a lack of structures for ensuring individualized rehabilitation. This qualitative focus group study aims to explore the experience of women with BC after participating in a complex randomized contr
BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati
