Filtyp
Sodium fluoroacetate (FA) is a metabolic poison that systemically inhibits the tricarboxylic acid (TCA) cycle, causing energy deficiency and ultimately multi-organ failure. It poses a significant threat to society because of its high toxicity, potential use as a chemical weapon and lack of effective antidotal therapy. In this study, we investigated cell-permeable succinate prodrugs as potential tr
Background: Rectal washout (RW) is routinely performed during anterior resection (AR) for rectal cancer to reduce local recurrence (LR), although is sometimes not performed during minimally invasive surgery (MIS) procedures due to technical challenges and time consumption. The aim was to investigate the impact of RW on the oncological outcome after AR for rectal cancer in a registry cohort. Method
Samverkan har sedan lång tid tillbaka varit viktigt inom både regionala ochkommunala verksamheter och det finns mycket som talar för attsamverkansbehoven kommer att öka än mer. Inom hälso- och sjukvården finns en kontinuerlig utveckling mot ny och mera specialiserad kunskap som även fårorganisatoriska konsekvenser. Teamarbete i vården har blivit allt viktigare, liksom nivåstrukturering och koncentCooperation has long been important within both regional andmunicipal activities and there is much to suggest thatcollaboration needs will increase even more. Within health care there is onecontinuous development towards new and more specialized knowledge that also gains organizational consequences. Teamwork in healthcare has become increasingly important, as well level structuring and concentrati
The encapsulation of colloidal lead halide perovskite nanocrystals within silica (SiO2) is one of the strategies to protect them from polar solvents and other external factors. Here, we demonstrate the overcoating of CsPbBr3 perovskite nanocrystals with silica by exploiting the anhydride-induced transformation of Cs4PbBr6 nanocrystals. CsPbBr3@SiO2 core–shell nanocrystals are obtained after (i)
3D foam scaffolds were produced in a "bottom-up" approach from lyophilised cationic cellulose nanofibril (CCNF) dispersions and emulsions (CCNF degree of substitution 23.0 ± 0.9%), using a directional freezing/lyophilisation approach, producing internal architectures ranging from aligned smooth walled micro channels, mimicking vascularised tissue, to pumice-like wall t
The fundamental importance of membrane proteins in drug discovery has meant that membrane mimetic systems for studying membrane proteins are of increasing interest. One such system has been the amphipathic, negatively charged poly(styrene-co-maleic acid) (SMA) polymer to form "SMA Lipid Particles" (SMALPs) which have been widely adopted to solubilize membrane proteins directly from the cell membra
This chapter explores the facilitation of reflective practice to aid and guide educators seeking to develop these soft skills and to assist them in developing educational programmes in the international classroom. Knowledge about learning, teaching, and education is a basic requirement. Few institutions, if any, would dispute the need for teaching staff to have an inventory of skills and expertise
Enzyme-responsive hydrogels, formed by step growth photopolymerization of biscysteine peptide linkers with alkene functionalized polyethylene glycol, provide interesting opportunities as biomaterials and drug delivery systems. In this study, we developed stimuli-responsive, specific, and cytocompatible hydrogels for delivery of anti-inflammatory drugs for the treatment of inflammatory skin disease
Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify
Observed declines in pollinator populations due to human pressures is of critical concern because pollination is an essential regulating ecosystem service (ES). Pollination has a major role in human food production and in maintaining flowering plant diversity. Estimating the pollination ES and its trends is thus essential for informing policy and management. However, the pollination ES remains poo
ALADDIN is a proposed fixed-target experiment at the LHC for the direct measurement of charm baryon dipole moments. The detector features a spectrometer and a Cherenkov detector, while the experimental technique is based on the phenomena of particle channelling and spin precession in bent crystals. TWOCRYST, a proof-of-principle test at the LHC for the proposed experiment, is planned during the LH
Purpose: This study investigated the use of surface guided radiotherapy (SGRT) in combination with a tomotherapy treatment mode using discrete delivery angles for deep inspiration breath hold (DIBH) treatments of breast cancer (bc). We aimed to assess the feasibility and dosimetric advantages of this approach. Materials and methods: We evaluated camera occlusion in the Radixact treatment system bo
The short-time iterative adaptive approach is a spectral estimation alternative to the short-time Fourier transform for non-stationary vibration analysis. This technique offers a reduction in leakage effects and a higher resolution in exchange for a higher computational complexity. The short-time iterative adaptive approach can be summarized as a high-resolution data-dependent approach which has b
Increased adoption of PV systems can help to mitigate climate change as it increases the use of renewable energy instead of fossil fuels and thus decreases greenhouse gas emissions.
The aim of this study was to investigate Swedish children's and parents' attitudes and knowledge about human papillomavirus (HPV) vaccination a year after gender-neutral HPV vaccination was introduced in Sweden's national immunization program (NIP). Additional information about HPV and vaccine was provided in the extended immunazation program. In total, 276 parents and 206 children from 22 School
Rocky planets may acquire a primordial atmosphere by the outgassing of volatiles from their magma ocean. The distribution of O between H2O, CO, and CO2 in chemical equilibrium subsequently changes significantly with decreasing temperature. We consider here two chemical models: one where CH4 and NH3 are assumed to be irrevocably destroyed by photolysis and second where these molecules persist. In t
The impacts of climate change may be particularly severe for geographically isolated populations, which must adjust through plastic responses or evolve. Here, we study an endangered Arctic plant, Primula nutans ssp. finmarchica, confined to Fennoscandian seashores and showing indications of maladaptation to warming climate. We evaluate the potential of these populations to evolve to facilitate sur
