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Production of 5-hydroxymethylfurfural from sugar beet molasses as feed-stock should in theory be a straight-forward process: first, hydrolysis of sucrose, followed by dehydration of fructose, but is in reality challenging. The enzyme-catalysed sucrose hydrolysis is inhibited by impurities and the dehydration of fructose has low conversions. In this study, pretreatment of crude molasses through pur
Adjuvant treatment of nonmetastatic high-risk renal cell carcinoma is an unmet medical need. In the past, several tyrosine kinase inhibitor trials have failed to demonstrate an improvement of disease-free survival (DFS) in this setting. Only one trial (S-TRAC) provided evidence for improved DFS with sunitinib but without an overall survival (OS) signal. Keynote-564 is the first trial of an immune
This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of t
Pseudomyxoma Peritonei (PMP) is a rare peritoneal malignancy, most commonly originating from a perforated epithelial tumour of the appendix. Given its rarity, randomized controlled trials on treatment strategies are lacking, nor likely to be performed in the foreseeable future. However, many questions regarding the management of appendiceal tumours, especially when accompanied by PMP, remain unans
We report on measurements of a charge-dependent flow using a novel three-particle correlator with ALICE in Pb-Pb collisions at the CERN Large Hadron Collider (LHC), and discuss the implications for observation of local parity violation and the chiral magnetic wave (CMW) in heavy-ion collisions. Charge-dependent flow is reported for different collision centralities as a function of the event charge
The core-multishell wurtzite structure (In,Ga)As–(Ga,Al)As–(Ga,Mn)As semiconductor nanowires have been successfully grown on GaAs(111)B substrates using MBE technique. The nanowires cores were grown with gold eutectic catalyser in vapour–liquid–solid growth mode. The double shell overgrowth, on the side facets of nanowires, was performed using lower substrate temperature (about 400 ◦C, and 230 ◦C,
A search for magnetic monopoles and high-electric-charge objects is presented using 34.4 fb-1 of 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015 and 2016. The considered signature is based upon high ionization in the transition radiation tracker of the inner detector associated with a pencil-shape energy deposit in the electromagnetic calorimeter. The data were coll
Water demand growth coupled with its high spatial-temporal mismatch of water resources will lead to an increasing water scarcity worldwide. In order to investigate a robust long-term water stress for ecosystems and regions across China, the improved maximum entropy production (MEP) method was utilized to obtain a reliable evapotranspiration (ET) product during 1982–2015. Afterwards four water stre
This thesis is a study of Twelver Shi’a Islam in the context of Azeri-Turkish Muslims living in the Anatolia-Caucasus borderlands of Northeastern Turkey. Taking the sonic as the central focus and field of enquiry I listen to the ways that sound mediates between bodies, both somatic and social, and the divine in the ritual and quotidian lives of Shi’i practitioners. I argue that sound, voice and li
Electrification of commercial heavy vehicles has led to the offer of different electric drive-based powertrain architectures, most of them with the adaptation of the diesel engine based architecture. Due to the limited driving range possible, optimal configuration of the powertrain becomes a vital task with the battery as the energy source, which also takes a significant portion of payload capacit
In the challenge to reduce CO2, NOx and PM emissions, the application of natural gas or biogas in engines is a viable approach. In heavy duty and marine, either a conventional dual fuel (CDF), or a reactivity-controlled compression ignition (RCCI) approach is feasible on existing diesel engines. In both technologies a pilot diesel injection is used to ignite the premixed natural gas. However, the
BackgroundLiver metastases are a common consequence of colorectal cancer. When feasible, surgical resection is first-line treatment. Synchronous disease can be treated with different strategies. Traditionally, the primary tumour is resected first followed by resection of the liver metastases (bowel-first). The other option, which is increasing, is the liver-first strategy, where resection of the l
PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch
Housing expenses have the highest share in household budgets of low-income groups in Copenhagen leading to affordability problems. To provide affordable housing (AH) for low-income groups, the municipality developed a zoning plan in 2015 aimed to reserve up to 25% of land for new AH production. This qualitative case study compares the affordability of homes produced by private sector and nonprofit
INFORM is a prospective, multi-national registry gathering clinical and molecular data of relapsed, progressive or high-risk pediatric cancer patients. This report describes long-term follow-up of 519 patients in whom molecular alterations were evaluated according to a pre-defined 7-scale target prioritization algorithm. Mean turnaround time from sample receipt to report was 25.4 days. The highest
