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Changes in the characteristics of cyclone activity (frequency, depth and size) in the Arctic are analyzed based on simulations with state-of-the-art regional climate models (RCMs) from the Arctic-CORDEX initiative and global climate models (GCMs) from CMIP5 under the Representative Concentration Pathway (RCP) 8.5 scenario. Most of RCMs show an increase of cyclone frequency in winter (DJF) and a de
BackgroundThe majority of people with dementia prefer to live independently and safely in their own home cared for by their family members. Much effort has been invested in the development of technology, such as sensor‐based networks. Many challenges remain, in particular gaining more knowledge about their experiences and perceived benefits. This study aimed to explore experiences, needs and benef
Aim: Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35 + 0 weeks. Methods: A PubMed sea
Purpose: Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes a major determining factor for the poor prognosis of high-grade glioma patients, and is known to contribute to the development of treatment resistance. Therefore, new strategies to comprehensively profile and monitor the hypoxic status of gliomas are of high clinical relevanc
Metamorphic provinces such as the ∼1 Ga Grenvillian, ∼400 Ma Caledonide and Triassic Qinling Provinces often contain rocks with high-pressure assemblages such as eclogites, which formed at mantle depths in subduction zones. These are evidence of the accretion of terranes by subduction of oceans and collision to form large tectonostratigraphic provinces. The Mesoproterozoic Namaqua-Natal Province
Climate variability is highly impacting on mosquito-borne diseases causing malaria and dengue fever across the globe. Seasonal variability change in temperature and rainfall patterns are impacting on human health. Mosquitoes cause diseases like dengue fever, yellow fever, malaria, Chikungunya, West Nile and Japanese encephalitis. According to estimations by health organizations, annually one milli
Sulphur-containing analogues of d-glucose were tested for effects on insulin release, d-glucose transport and d-glucose oxidation in microdissected pancreatic islets of obese-hyperglycemic mice. Substituting sulphur for oxygen in the ring structure of d-glucose (5-thio-d-glucose) resulted in a total loss of insulin-releasing ability. 5-Thio-d-glucose inhibited d-glucose-stimulated insulin release,
Through an analysis of the FDA’s approval of the controversial anti-influenza drug Relenza (zanamivir), we interrogate distinct social scientific theories of pharmaceutical regulation. We investigate why, despite internal negative opinions and an Advisory Committee’s non-approval recommendation, the FDA approved Relenza in the late 1990s. Based on a close reading of FDA documents, we show how agen
This article is a revised version of a keynote given at the 18th Nordic Conference on Systematic Theology: Hope in Dark Times, held in Stavanger on 10–13 January 2019. The aim of the article is to ponder how Jewish and Christian discourses on hope can contribute in a critical way to contemporary political and philosophical discussions of hope. Taking its cue from the biblical idea of messianic red
Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines
The main objective of the study was to investigate the thermal performance of five (open and closed) bicycle helmets for convective and evaporative heat transfer using a nine-zone thermal manikin. The shape of the thermal manikin was obtained by averaging the 3D-point coordinates of the head over a sample of 85 head scans of human subjects, obtained through magnetic resonance imaging (MRI) and 3D-
Background: Depression is among the major causes of disability with a negative impact on both daily life and work performance. Whilst depression is the primary cause of sick-leave and unemployment in today's workplace there is a lack of knowledge of the needs of individuals with depression regarding their return-to-work (RTW) process. Objective: To explore which factors are of critical importance
Aim: To investigate self-reported needs for care, support and treatment among persons who frequently visit psychiatric emergency rooms (PERs).Design: A cross-sectional design. Qualitative and quantitative data were collected using an interview-based manual. Qualitative data were analysed using content analysis, whereas quantitative data were analysed using descriptive, non-parametric statistical t
PURPOSE: To assess and compare the costs of first-line monoclonal antibodies (mAbs) treatment protocols in breast cancer, non-Hodgkin lymphoma and colorectal carcinoma in South-Eastern Europe.METHODS: A retrospective, bottom-up case series study design was implemented with one-year time horizon and payer's perspective. The study sample size was 265 patients (breast cancer, N=137; colorectal cancer
Due to the limited cooling capacity of air, large-scale proton exchange membrane (PEM) fuel cell stacks are generally cooled by liquid cooling where liquid water is circulated through the flow channels of cooling plates. Effective cooling is essential for the stability, durability, and performance of PEM fuel cells. In this study, cooling plates with conventional straight channel and novel non-uni
Background: Venous thromboembolism (VTE) is the third most frequent life-threatening cardiovascular disease with an annual incidence rate of 1-2 per 1000 person-years. After the diagnosis for primary VTE, about 20-30% patients develop a recurrence within 5-years. VTE recurrence can be prevented by anticoagulants, albeit at the risk of severe bleeding. Heritability of VTE is high and hereditary fac
This study compares the precipitation trend from the gridded rain gauge data collected by India Meteorological Department (IMD) and Multisatellite High Resolution Precipitation Products (HRPPs) including Tropical Rainfall Measurement Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) version 7, Climate Prediction Center Morphing (CMORPH) version 1.0, Precipitation Estimation from Remotely
The role of exogenous sources of new path development has been underplayed in the literature on regional industrial change so far. The aim of this article is to explore in a conceptual way under which conditions and in what ways non-local knowledge can lead to new path development in different regional innovation systems (RISs). We distinguish between organizationally thick and diversified RISs, t
