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The increasing interest in seaweed as a food resource in Western societies raises concerns about associated potentially toxic elements (PTEs), including arsenic, cadmium, mercury, lead, and iodine. Hence, this study examined variation in PTEs by including samples of four different species (Ulva lactuca, Palmaria palmata, Alaria esculenta, and Saccharina latissima) from Ireland, as well as of a sin
Global reconstructions, inclusive of environments and ecosystems, and biodiversity counts for the Devonian Period are often done so at the expense of high latitude regions given a historical lack of data presented from these areas. This has bearing on the recognition of biocrises (events marked by extinctions and faunal turnovers) at high latitudes as well as their controls and potential correlati
GJ 367 is a bright (V ≈ 10.2) M1 V star that has been recently found to host a transiting ultra-short period sub-Earth on a 7.7 hr orbit. With the aim of improving the planetary mass and radius and unveiling the inner architecture of the system, we performed an intensive radial velocity follow-up campaign with the HARPS spectrograph—collecting 371 high-precision measurements over a baseline of nea
A search for pair-produced vector-like quarks using events with exactly one lepton (e or μ), at least four jets including at least one b-tagged jet, and large missing transverse momentum is presented. Data from proton–proton collisions at a centre-of-mass energy of s= 13 TeV , recorded by the ATLAS detector at the LHC from 2015 to 2018 and corresponding to an integrated luminosity of 139 fb - 1 ,
Background: The ongoing Pan-European Real Life (PEARL) phase 4 study is evaluating fremanezumab effectiveness and safety for the prevention of episodic and chronic migraine. This interim analysis reports primary, secondary and exploratory endpoints from when 500 participants completed at least six months of treatment. Methods: Adults with episodic migraine or chronic migraine maintaining daily hea
Adjuvant bacillus Calmette-Guérin (BCG) instillations represent a cornerstone in the treatment of non–muscle-invasive bladder cancer. Instillation schedule and dose modifications have been evaluated in efforts to reduce the incidence of adverse events (AEs), but none so far has the same treatment efficacy as the full-dose recommended schedule. It has been shown that prophylactic quinolone use in c
Decentralized water reuse technologies are increasingly being explored as a transformative approach for complementing centralized water and wastewater infrastructure. A transition to onsite water reuse requires a better understanding of how urban infrastructures are governed. While governance tends to be discussed within ideal types─i.e., hierarchy, market, and network─researchers increasingly rec
Studies on patients with bladder outflow obstruction who have undergone surgery for benign prostatic hyperplasia, successfully relieving the obstruction, have revealed a persistence of storage symptoms associated with detrusor overactivity (DO) in 20% to 40% of patients. To study the underlying mechanisms, we have used a common rat model of obstruction/de-obstruction, assuming that non-voiding con
Introduction: Whether and under what conditions scientific knowledge provided by experts actually leads to political action is a question that academic research in various fields have focused on at length, without reaching a definitive answer. The position of expertise is especially delicate within the global environmental governance sphere containing multiple values, worldviews and epistemologica
This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota
Background: After an older person moves into a nursing home, the next of kin often continues to participate in the care provided there. This participation in care may contribute valuable knowledge of the preferences and wishes of the older person, thereby helping nursing staff deliver personalised care. Objectives: The aim of this study was to explore how next of kin experience their participati
Biocompatibility studies, especially innate immunity induction, in vitro and in vivo cytotoxicity, and fibrosis, are often lacking for many novel biomaterials including recombinant protein-based ones, such as elastin-like recombinamers (ELRs), and has not been extensively explored in the scientific literature, in contrast to traditional biomaterials. Herein, we present the results from a set of ex
Vitrified bonded aluminum oxide grinding wheels are widespread in use for many applications in grinding, such as internal plunge grinding. However, there are challenges when it comes to the measurement, analysis and (geometric) modeling of their topography, which is crucial to understand and model the influence of the topography on the process behavior. Methodological advances allow for the detail
Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by increasing aromatase activity and
Many studies that use an automated sorption balance to determine a water vapor sorption isotherm for wood collect data until the moisture content change is less than or equal to 0.002% min−1 (20 µg g−1 min−1). This stop criterion has been claimed to give errors in equilibrium moisture content (EMC) predictions of less than 0.001 g g−1 but over the past 10 years, studies have shown that the actual
INTRODUCTION: Blood-based biomarkers (BBMs) have revolutionized Alzheimer's disease diagnosis and monitoring. Their pre-analytical stability requires scrutiny. This study assessed pre-analytical effects to inform a standardized sample handling protocol. METHODS: Assessed pre-analytical variations included collection tube type, hemolysis, centrifugation settings, centrifugation/storage delays, tube
A search for dark mesons originating from strongly-coupled, SU(2) dark flavor symmetry conserving models and decaying gaugephobically to pure Standard Model final states containing top and bottom quarks is presented. The search targets fully hadronic final states and final states with exactly one electron or muon and multiple jets. The analyzed data sample corresponds to an integrated luminosity o
Carbon starvation induces the development of a starvation- and stress- resistant cell state in marine Vibrio sp. strain S14 (CCUG 15956). The starved cells remain highly responsive to nutrients during prolonged starvation and exhibit instantaneous severalfold increases in the rates of protein synthesis and RNA synthesis when substrate is added. In order to elucidate the physiological basis for the
