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PURPOSE: To describe a specific cone-rod dystrophy phenotype in a family with the homozygous c.1429G>A; p.Gly477Arg mutation in CRB1. The detailed phenotype of subjects with this specific mutation has not been described previously. METHODS: Clinical examination included full-field electroretinography and high-resolution and widefield retinal imaging and uveitis workup. Molecular genetic analysis i

Background Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfi rmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods We did this 7

Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the Alzheimer's disease continuum. The aim of this study was to investigate how plasma NfL relates to amyloid and tau PET and MRI measures of brain atrophy in participants with and without cog

Consumer choice policies may improve the matching of consumers and providers, and may spur competition over quality dimensions relevant to consumers. However, the gains from choice may fail to materialise in markets characterised by information frictions and switching costs. We use two large-scale randomised field experiments in primary health care to examine if individuals reconsider their provid

BACKGROUND AND PURPOSE: To date, large studies comparing mortality and functional outcome of intracerebral hemorrhage (ICH) during oral anticoagulant (OAC), antiplatelet, and nonantithrombotic use are few and show discrepant results. METHODS: We used data on 13 291 patients with ICH registered in Riksstroke between 2012 and 2016 to compare 90-day mortality and functional outcome following OAC-rela

I denna avhandling utvecklar jag förståelsen kring avstigmatiseringsprocesser till att inkludera produkters avstigmatisering. Tidigare forskning kring avstigmatisering har främst fokuserat på individer, grupper, organisationer och industrier. Dock finns det en mängd empiriskt bevis som vittnar om att produktstigma har signifikanta effekter på marknadslogiker, inklusive enligt lag bestämda produktkIn this thesis, I develop our understanding of the destigmatization process to include product destigmatization. Previous research on destigmatization has primarily focused on that of individuals, groups, organizations, and industries. However, there is an abundance of empirical evidence showing that a product stigma has a significant bearing on market logics, including legal classification of pro

This doctoral thesis examines the attribution of criminal responsibility in Swedish law in cases where the defendant committed an act during an atypical mental state, e.g. psychosis. In nearly all criminal justice systems, a severe mental disorder can activate special rules that excuse or exempt the defendant. Accountability, or the capacity to be responsible, is a fundamental requirement for crim

Spatial Data Infrastructure (SDI) provides a platform for spatial data sharing and is a key for sustainable development. Developing countries, including Tanzania, are at different stages of implementing SDIs. The importance and advantage of implementation lie in the fact that considerable funds can be saved by avoiding duplication of data, and improving quality of decisions making as well as publi

Background: Cadmium (Cd) exposure during gestation has been associated with altered DNA methylation at birth, but it is not known if the changes in methylation persist into childhood. Objectives: To evaluate whether gestational Cd-related changes of DNA methylation persist from birth to 9 years of age. Methods: We studied mother–child dyads in a longitudinal cohort in rural Bangladesh. Cadmium con

The United Nations has declared climate change a code-red for humanity and the 2020s the decisive decade to avoid dangerous climate disruption. The 26th Conference of the Parties in Glasgow, Scotland represents a milestone event and potentially the last chance to keep the Paris Climate Agreement 1.5 °C policy goal within reach. The tourism sector has responded to this critical moment by releasing

Objective: The aim of this study was to evaluate the contemporary population based incidence of acute lower limb ischaemia (ALI) and factors associated with major amputation/death at one year. Methods: In this retrospective observational study, in hospital, operation, radiological, and autopsy registries were scrutinised to capture 161 citizens of Malmö, Sweden, with ALI between 2015 and 2018. Age

There is relatively little research on women’s involvement with drugs in the Nordic area. While women’s experiences have enjoyed greater attention in the literature than previously (Chesney-Lind and Chagnon, 2016), many analyses appear to consider gender as a single variable in addition to class. Further, gender has become synonymous with women, ‘as if the other, the general’ were not also similar

The alternating between dry and wet seasons and the consecutive microbial responses to soil water content in semiarid ecosystems has significant consequences on nitrogen exchanges with the atmosphere. Three field campaigns were carried out in a semi arid sahelian rangeland in Dahra (Ferlo, Senegal), two at the beginning of the wet season in July 2012 and July 2013, and the third one in November 20

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukoc

Acute and chronic lung diseases are a major cause of global mortality. While pharmacological approaches exist, no therapies are curative. The only option at end-stage disease is lung transplantation which is hampered by a chronic shortage of donor organs. Therefore, there is a high interest to develop alternative approaches to use regenerative medicine approaches to generate new lung tissue in the

Background: Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention. These issues may be exacerbated when recruiting vulnerable populations, such as participants with mental health issues. We aimed to update understanding of the scope of these problems in trials of health techn

This study investigated the dosimetric impact of uncompensated motion and motion compensation with dynamic multileaf collimator (DMLC) tracking for prostate intensity modulated arc therapy. Two treatment approaches were investigated; a conventional approach with a uniform radiation dose to the target volume and an intraprostatic lesion (IPL) boosted approach with an increased dose to a subvolume o

lectric surfboards are a fairly new innovation. They fuse the art of surfing into technology and deliver a fresh experience to their users. That feeling has made them want more. Also the reason why electric surfboards are gaining popularity. How can you redesign an electric surfboard? What more do you want to experience when you are already cruising on the water at high speeds. The electrified sur