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Vid kronisk myeloisk leukemi har målstyrd, kontinuerlig behandling med tyrosinkinashämmare lett till dramatiskt förbättrad överlevnad. Efter ett flertal år uppnås djupt molekylärt svar hos ca 50 procent av patienterna; ca 50 procent av dem kan då avbryta behandlingen utan tecken på återfall. Kontinuerlig behandling med tyrosinkinashämmare kan ge långsiktiga biverkningar. Efter patentutgång för imaChronic myeloid leukemia - a model disease for targeted therapy Chronic myeloid leukemia (CML) pioneered as the first human malignancy linked to a specific cytogenetic aberration (the Philadelphia chromosome), which led the way to specific targeted therapies with imatinib (Glivec) and later tyrosine kinase inhibitors (TKI). Continuous TKI administration, blocking the oncogenic fusion protein Bcr-A

För korrekt beskattning i komplicerade mål är det viktigt att Skatteverket kan utvärdera och presentera sakomständigheter på ett kvalificerat sätt. Skattebetalare med hög kompetens har annars större möjligheter att hävda sin rätt jämfört med skattebetalare som saknar sådan kompetens, vilket står i konflikt med likabehandlingsprincipen. I artikeln illustreras vikten av en kvalificerad förvaltningsm

Emergency Medicine became a supraspeciality in Sweden in 2008. The Swedish Specialist Examination in Emergency Medicine is a formative examination that seeks to guide local training in Emergency Medicine, provide feedback to physicians during their residency, and establish national standards for various processes in Emergency Medicine. It consists of six partial examinations and 118 cases. Documen

#092. In Silence, I hide my loudest scream, for 9 instruments (a.fl., b.cl., tpt., tbn.,perc., vl. 1 & 2, vla., vlc) (2015). Premiere: China-Asean Youth Orchestra, conducted by Michael Edgerton. Guangxi National Palace concert hall on 2015_06_06.

Detailed reaction kinetics of acrolein + H and related chemistry and its influence on the ignition delay time prediction of acrolein has been studied theoretically in this work. The geometry optimization and vibrational frequency calculations for every stationary point were performed at the BH&HLYP/6–311++G(d,p) level of theory, with one-dimensional hindered rotation treatments applied for low

Lärares praktiska yrkeskunskaper bjuder motstånd mot förspråkligande. Detta problem föreligger inte minst i lärarutbildningen, där det i verksamhetsförlagda delar kan råda både osäkerhet och skilda uppfattningar om vad studenterna behöver göra eller prestera för att uppnå de mål som (bokstavligen) föreskrivits dem. Syftet med avhandlingen har varit att beskriva och förstå villkor och förutsättningTeachers' practical professional skills offer resistance to advocacy. This problem exists not least in teacher education, where in work-based parts there can be both uncertainty and different perceptions of what the students need to do or perform in order to achieve the goals that are (literally) prescribed for them. The purpose of the dissertation has been to describe and understand conditions an

The fact that we apprehend certain phenomena as more convenient than others generate questions about what constitute and decide what we think of as normal and appropriate. The aim of this thesis is to explore the immense conception of power and authority through a narrower approach that focuses on the EU. With this in mind I examine the penetration of the neo-liberal ideology in the Treaty establ

The purpose of this paper is to identify significant factors of influence for the co-existence and team climate within working groups, and to examine their impact on the psychosocial work environment within a group. Team climate and interaction affect every individual in a group. The manager, however, is the one formally accountable for the psychosocial climate in a working group, which is the rea

The purpose of this essay was to examine what Ungbo in Kalmar has meant for the adolescent from their point of view and to examine the social workers opinions of Ungbo. My questions were: What expectations did the adolescent and the social workers have on Ungbo? How has these expectations been fulfilled? What expectations does the social workers think the adolescents has on Ungbo? How is the impa

Populärvetenskaplig sammanfattning: Våtmarkers utvecklingshistoria kan rekonstrueras genom att deras lagerföljd undersöks. Genom att studera de sediment, växtdelar och pollen som en våtmark är uppbyggd av kan man dra slutsatser om hur den bildats och hur dess utbredning varierat på grund av klimatförändringar och/eller mänsklig påverkan. Rekonstruktioner av förändringar i våtmarkers utbredning bidWetlands are of uttermost biological importance as they function as natural purifiers, absorb nitrogen, and contribute to the landscape biodiversity. In a long term, the history and change, in area- and volume extent, of wetlands reflect climate trends through time. This master’s thesis is an attempt to develop a methodology that in a simple and robust way reconstructs wetland changes using sedime

BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl

Transgender people report significantly poorer mental health than cisgender people. In psychological research, these health disparities are explained by theories of minority stress and microaggressions, while other disciplines use theories on normativity, livability, affective work, world making and utopias. Such theories are seldom picked up by psychologists even though they could serve to help p

De senaste åren har det kommit många prejudikat rörande medansvar vid kritisk kapitalbrist i 25 kap. aktiebolagslagen (ABL). I ett nytt prejudikat klargör Högsta domstolen när ett aktiebolags förpliktelse att lämna ersättning för rättegångskostnader ska anses ha uppkommit vid tillämpning av 25 kap. 18 § ABL. Trots den ofta upprepade utgångspunkten att reglernas ändamål är att verka handlingsdirige