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Despite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an

Along with the ever-expanding interest in brands, the brand orientation concept has since its inception in the early 1990s steadily received more and more attention from scholars and practitioners alike. Brand orientation ultimately captures how organisations can develop sustainable competitive advantages in the form of brands. However, the conditions for brand management have dramatically changedAlong with the ever-expanding interest in brands, the brand orientation concept has since its inception in the early 1990s steadily received more and more attention from scholars and practitioners alike. Brand orientation ultimately captures how organisations can develop sustainable competitive advantages in the form of brands. However, the conditions for brand management have dramatically changed

Background:Traditional primary care is characterized by patient consultations via phone and physical visits. However, the current development in Swedish primary care is to blend digital solutions with traditional solutions. This paper addresses this development by examining the normalization of embedding and integrating a digital health care platform into everyday care routines in a primary care cBackground:Traditional primary care is characterized by patient consultations via phone and physical visits. However, the current development in Swedish primary care is to blend digital solutions with traditional solutions. This paper addresses this development by examining the normalization of embedding and integrating a digital health care platform into everyday care routines in a primary care c

Based on an ethnographic case study, this paper offers a typology of how, and under what circumstances, employees at a fast food-restaurant are cynical. By conducting participant- and non-participant observations and 10 semi-structured interviews, combined with a document analysis, we sought to understand the social realities of employees at Berger. Thus, we have had an interpretive approach to re

Popular Science AbstractHow well bees can see the world?aBees such as bumblebees and honeybees are some of the most important pollinators. They pollinate by using different sensory cues from the flowers, primarily vision and olfaction. In my PhD I was interested in understanding how well bees can see while they are inspecting flowers as well as while they are performing high-speed flight maneuversBees use multiple sensory modalities to perform day-to-day tasks. Light allows them to perceive objects and the general features of their surroundings, enabling them to find food and to navigate safely across the landscape. Although both these tasks involve vision, the requirements of the visual system differ depending upon what the bee wants to achieve; locate a flower to feed from or adjust its

Researchers have emphasized the child’s perspective within social science since the 1990’s which has resulted in a shift in the view of children within research towards the recognition that children are active, creative social agents in their own right. The main aim of this paper was to present methodological and ethical aspects regarding research with children on the basis of two propositions, thResearchers have emphasized the child’s perspective within social science since the 1990’s which has resulted in a shift in the view of children within research towards the recognition that children are active, creative social agents in their own right. The main aim of this paper was to present methodological and ethical aspects regarding research with children on the basis of two propositions, th

Bipolaris sorokiniana is the causal agent of multiple diseases on wheat and barley and is the primary constraint to cereal production throughout South Asia. Despite its significance, the molecular basis of disease is poorly understood. To address this, the genomes of three Australian isolates of B. sorokiniana were sequenced and screened for known pathogenicity genes. Sequence analysis revealed th

The adsorption from a mixture of SDS and β-Lactoglobulin, 1:5 (), onto a methylated silica surface was studied in situ by ellipsometry. The amounts adsorbed from different concentrations of the mixture, at pH 7, were compared with those adsorbed from the corresponding pure SDS and β-lactoglobulin solutions. At high concentrations of the mixture, where the CMC of SDS is approached or exceeded, the The adsorption from a mixture of SDS and β-Lactoglobulin, 1:5 (), onto a methylated silica surface was studied in situ by ellipsometry. The amounts adsorbed from different concentrations of the mixture, at pH 7, were compared with those adsorbed from the corresponding pure SDS and β-lactoglobulin solutions. At high concentrations of the mixture, where the CMC of SDS is approached or exceeded, the

When patients experience peripheral vestibular or certain central disorders causing dizziness or vertigo, this is sometimes associated with experiencing also disrupted spatial orientation, which may be accentuated by exposure to a distorted visual environment. This study explores the impact of sensorimotor factors and sex on spatial orientation in sitting and standing positions. In the Rod-and-Fra

As migrations from within and outside of Europe continue to increase steadily, particularly in the Mediterranean region, the integration of immigrant populations is one of the most pressing issues faced by many European countries. Although there is significant research on immigrant integration in urban areas, the settlement and integration of immigrants in rural areas is largely understudied, even

This paper is a comparative study of different approaches to using a Discrete Time Micro-structure model. By using the three filtering techniques Extended Kalman, Unscented Kalman and Bootstrap Particle, the hidden variables; excess demand and market liquidity, were estimated and used in an asset allocation strategy that invested in the asset when the excess demand as estimated as positive, due to

The purpose of this thesis is to critically examine whether China following the Third Plenary Session in December 1978 could be considered a developmental state with a focus on public bureaucracy. The research uses single case study research as its methodological approach, coupled with content analysis on secondary sources, to examine whether reforms after 1978 unfolded in a way that had tailored

Companies always strives to acheive as eective inventory control as possible. At the same time, a suciently high delivery accuracy to satisfy the customer is pursued. One prerequisite for successfully accomplishing this is to anticipate customer demand in advance. An approximation of the demand in advance is called forecasting. Forecasting implies that dierent techniques are used to predict future

The COVID-19 pandemic is classified as an infodemic with the circulation of vast amounts of true and untrue information, especially through social media. The study’s aim was to explore different articulations of people’s understanding, handling and evaluation of (true) information, misinformation and disinformation in general and specifically linked to social media related to the COVID-19 pandemicThe COVID-19 pandemic is classified as an infodemic with the circulation of vast amounts of true and untrue information, especially through social media. The study’s aim was to explore different articulations of people’s understanding, handling and evaluation of (true) information, misinformation and disinformation in general and specifically linked to social media related to the COVID-19 pandemic

Background: Older adults with pain have an increased risk of falling (odds ratio (OR) 1,7). Pain in Parkinson’s disease (PD) is more common than in older adults. The association between pain and falling in people with PD is poorly explored.Objective: To investigate the occurrence of pain in mild PD and its association with future falls/near fallsMethods. The study included 141 participants with PDBackground: Older adults with pain have an increased risk of falling (odds ratio (OR) 1,7). Pain in Parkinson’s disease (PD) is more common than in older adults. The association between pain and falling in people with PD is poorly explored.Objective: To investigate the occurrence of pain in mild PD and its association with future falls/near fallsMethods. The study included 141 participants with PD

This study argues that Brexit is as much an internal UK crisis of law, identity politics and democracy as it is the EU crisis of integration. Does Brexit bring us a new insight into how the legal order of the EU and its Member States are interrelated? Does it throw a new light on the EU law’s ability to produce a sense of collective European identity and solidarity which transcends national borderThis study argues that Brexit is as much an internal UK crisis of law, identity politics and democracy as it is the EU crisis of integration. Does Brexit bring us a new insight into how the legal order of the EU and its Member States are interrelated? Does it throw a new light on the EU law’s ability to produce a sense of collective European identity and solidarity which transcends national border

Brain-derived neurotrophic factor (BDNF) is an important protein for neuroplasticity and neurogenesis. In this thesis the role of BDNF, in suicidal behaviour was investigated with focus on possible risk factors for suicidal behaviour such as avoidant focused coping, dysfuntional personality traits like impulsiveness and hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis.Paper I: The as

Due to relatively low patronage levels, rural bus stops are sometimes questioned in order to improve travel time and reliability on regional bus services. Previous research into stop spacing has focused on urban areas, which means that there is a lack of knowledge regarding the effects of bus stops in regional networks, with longer distances, higher speeds, and lower passenger volumes, in general.