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Evaluation of: Akada J, Kamei S, Ito A et al. A new type of protein chip to detect hepatocellular carcinoma-related autoimmune antibodies in the sera of hepatitis C virus-positive patients. Proteome Sci. 11(1), 33 (2013). Unlocking the proteome and delivering biomarkers to the clinic will be critical for early and improved diagnosis and prognosis. Conventional protein microarrays have evolved as a
Strategy and methodology is presented for the analysis of organic pollutants, with the purpose of evaluating treatment procedures for landfill leachate. Today, many investigations of treatment procedures are focusing on the measurement of water quality parameters such as chemical and biochemical oxygen demand, (COD and BOD), and total organic carbon, (TOC) when assessing the organic compounds in w
Popular Abstract in Swedish Genetisk påverkan i ledgångsreumatism Ett väl fungerande immunsystem är en förutsättning för kroppens kamp mot diverse sjukdomar orsakade av t ex virus och bakterier. En grundläggande egenskap hos immunsystemet är dess förmåga att skilja på vad som är kroppens egna celler och molekyler och vad som är främmande. Ibland fungerar inte denna diskriminering som den ska och In this thesis the role of major histocompatibility complex (Mhc) class II molecules in development of autoimmune disease such as rheumatoid arthritis (RA), was studied. By combining an experimental model for RA, collagen type II induced arthritis (CIA), with molecular biology methods the importance of polymorphism in Mhc class II genes for disease development was investigated. The Mhc region con
Theoretical models have been developed to address several important aspects of numerical modeling of turbulent combustion and flame spread. The developed models include a pyrolysis model for charring and non-charring solid materials, a fast narrow band radiation property evaluation model (FASTNB) and a turbulence model for buoyant flow and flame. In the pyrolysis model, a completely new algorithm
Background: Emergency Departments (EDs) today rely heavily on Electronic Health Records (EHRs) and associated support systems. EHR updates are known to be associated with adverse events, but reports on the consequences of breakdowns in EDs are lacking. Objectives: To describe the effects on workload, occupancy, patient Length Of Stay (LOS), and admissions at three EDs (a regional trauma center, a
Proportional-integral-derivative (PID) controllers are very common in the process industry. In a regular factory there may be hundreds or thousands of them in use. Each of these controllers needs to be tuned, and even though the PID controller is simple, tuning the controllers still requires several hours of work and adequate knowledge in order to achieve a desired performance. Because of that, ma
The aim of this study was to test age-appropriate information and preparation procedures for children with cancer undergoing radiotherapy (RT) for feasibility and effectiveness in terms of the need for general anesthesia (GA) and anxiety. In a quasi-experimental controlled clinical trial, 17 children aged 3–18 years receiving age-appropriate preparation were compared with 16 children in a control
OBJECTIVE: To obtain knowledge about factors that could influence women's informed choice and extent of prenatal diagnosis, her feelings when implementing it, and her satisfaction. METHOD: A questionnaire including Visual Analogue Scale was given to 823 women and replies received from 662 (80.4%). Ease of choice was the basis for the statistical analysis. RESULTS: The factors that most often influ
Ensuring energy security and mitigating climate change are key energy policy priorities. The recent Intergovernmental Panel on Climate Change Working Group III report emphasized that climate policies can deliver energy security as a co-benefit, in large part through reducing energy imports. Here, using five state-of-the-art global energy-economy models and eight long-term scenarios, we show that w
Osteoporosis is defined as low bone density, and results in a markedly increased risk of skeletal fractures. It has been estimated that about 40% of all women above 50 years old will suffer from an osteoporotic fracture leading to hospitalization. Current osteoporosis diagnostics is largely based on statistical tools, using epidemiological parameters and bone mineral density (BMD) measured with du
BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (≤ 1 mm).OBJECTIVES: The aim of the present study was to investigate the melanoma-specific survival (MSS) as well as conditional MSS (CMSS) in patients with thin CMM in Sweden.PATIENTS AND METHODS: Clinical and histological parameters we
The conspicuous retreat of the key species Fucus vesiculosus from the deeper parts of its former distribution area in the Baltic Sea has triggered extensive research on the factors that control its growth. Based on recently obtained knowledge on a large number of potential drivers, we developed a numerical model incorporating effects of abiotic factors on the physiological functions of photosynthe
Background: The healthcare sector needs to deliver evidence-based care and be cost-effective. This can be monitored in part via a national quality registry containing individualized data concerning patient problems, medical interventions, outcomes of treatment, and patient-reported outcomes. With this aim, Web Rehab Sweden was launched in 1997 and has been available online since 2007. The aim of t
An automated routine for the continuous calibration of thermographic phosphors was developed as a replacement for the conventional calibration scheme that relied on fixed temperature points. The automated calibration routine was validated using Mg 3 F 2 GeO 4 :Mn as a calibration phosphor. Hardware and software aspects of the calibration process were addressed in this development. The hardware asp
This study investigates particulate matter (PM) and regulated emissions from renewable rapeseed oil methyl ester (RME) biodiesel in pure and blended forms and contrasts that to conventional diesel fuel. Environmental and health concerns are the major motivation for combustion engines research, especially finding sustainable alternatives to fossil fuels and reducing diesel PM emissions. Fatty acid
We study how childhood neighborhood SES affects cause-specific health in adulthood. By using geocoded longitudinal microdata for the city of Landskrona, 1939-1967, linked to Swedish national registers, 1968-2015, we apply a life-course of place approach to measure cumulative neighborhood conditions. From 1939 to 1967, the whole population is geocoded at the address-level, and we observe their full
