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Eukaryotic cells employ the RNA interference (RNAi) machinery in the cytosol to downregulate gene expression. Short 21-nucleotide microRNAs (miRNAs) associate with the so-called RNA induced silencing complex (RISC) and hybridize with the target gene’s mRNA, preventing it from being translated into protein. Employing the RNAi machinery with synthetic small interfering RNAs (siRNAs) that mimics the

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Current pallet configurations, specifically pallet heights, are hindering the packaging solutions provider, Boxon Pak AB, from making an optimum use of transport resources. Differences in pallet heights in combination with the vertical space limitation of the transportation units sometimes preclude double stacking the pallets, which delivers as a consequence the shipment of unfilled trucks and und

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Due to the fact that urbanization increases cities are getting denser. With increasing population comes increased demand for goods and services. However, the more transportation of goods within urban areas the more greenhouse gases is emitted and particular matter spread. In addition to this, an increasing amount of heavy vehicles lead to noise pollution and congestion, which could limit a city’s

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This chapter outlines how the history of health care in Syria has shaped the way in which wartime health care has been delivered and controlled. The chapter analyzes the claim by humanitarian organizations to a form of neutrality in the Syrian war, which was ultimately incompatible with the way the Syrian state and the opposition saw aid delivery as part of the battle for statehood. It also mentio

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Achieving CRISPR Cas9-based manipulation of mitochondrial DNA (mtDNA) has been a long-standing goal and would be of great relevance for disease modeling and for clinical applications. In this project, we aimed to deliver Cas9 into the mitochondria of human cells and analyzed Cas9-induced mtDNA cleavage and measured the resulting mtDNA depletion with multiplexed qPCR. In initial experiments, we fou

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Journal of Visualized Experiments www.jove.com Copyright © 2019 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License June 2019 | 148 | e59465 | Page 1 of 9 Video Article In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors Maria Pereira1, Marcella Birtele1, Daniella Rylander Ottosson1 1Department of Experimental Medi

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/jove_0.pdf - 2026-07-17

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Popular Abstract in Swedish Fall och frakturer hos äldre är ett vanligt förekommande och ökande hälsoproblem, som orsakar fysiska, sociala och psykologiska problem hos den enskilde och är kostsamt för samhället. Syftet med avhandlingen är att undersöka fallolyckor bland de patienter i åldern 65-74 år som kommit till ortopedklinikens akutmottagning, att undersöka reliabiliteten beträffande gångtestFalls and fractures in older people are a common and increasing health problem which causes physical, social and psychological problems for the individual and is costly to society. The aims of this thesis were to investigate accidental falls of patients aged 65 - 74 who attended an orthopedic emergency ward, to investigate reliability of the modified figure of eight (MFE) and compare it with other

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Popular Abstract in Swedish Populärvetenskaplig sammanfattning på svenska Abort är ett av de vanligaste kriurgiska ingreppen i Sverige. 1989 var aborttalet för hela landet 21.5 per 1000 kvinnor i åldern 15-24 år. Storstäderna Stockholm, Göteborg och Malmö har i många år haft det högsta aborttalen, vilka var för dessa 1989 28.4, 27.0 respektive 27.8. De aktuella studierna omfattar de 1466 kvinnorIn Sweden between 32-38,000 women annually elect to terminate pregnancy by means of induced abortion, though their reasons are still not well understood. The purpose of these studies, carried out at the Department of Obstetrics and gynecology and of Community Medicine at University Hospital, Malmö, was to elucidate the incidence of induced abortion in an urban population, with special emphasis on

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Biopharmaceuticals, of which monoclonal antibodies are a mainstay, have revolutionized healthcare by enabling treatments with high precision and efficacy. However, their established manufacturing processes, particularly the downstream process, are complex, resource-intensive, and expensive, limiting global access to these drugs. This thesis examines how a more efficient, sustainable, and thus less

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Taboo obsessions are ego-dystonic, recurrent, and intrusive thoughts involving aggressive, sexual and/or religious themes, which are common in individuals with obsessive-compulsive disorder (OCD). These symptoms are often challenging to treat with traditional, exposure-based approaches. Our research group has developed and successfully piloted an Internet-delivered intervention based on the cognit

Actions In Teaching At INES In Response To Covid Spring 2021

Actions in teaching at INES in response to Covid-19 related restrictions, spring 2021 Authors: INES management group, Jonathan Seaquist, Lars Eklundh, Petter Pilesjö & Ulrik Mårtensson Date: 2021-02-25 Validity: until further notice The guidelines and actions below should be followed at INES to ensure staff and student safety with regard to Covid-19 disease spread. It is the responsibility of all

https://www.nateko.lu.se/sv/sites/nateko.lu.se.sv/files/2021-03/Actions%20in%20teaching%20at%20INES%20in%20response%20to%20Covid%20spring%202021.pdf - 2026-07-17

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År 2018 meddelade EU-domstolen förhandsavgörandet C-284/16 Achmea som kom att göra investeringstvister mellan en investerare från en EU-medlemsstat mot en annan EU-medlemsstat osäker. I domslutet konstate-rade EU-domstolen att artiklarna 267 och 344 Fördraget om Europeiska unionens funktionssätt utgjorde hinder mot en sådan skiljeklausul som fanns i ett bilateralt investeringsavtal mellan SlovakieIn 2018, the Court of Justice of the European Union (CJEU) rendered its preliminary ruling C-284/16 Achmea, making the future of investment treaty arbitration between an investor from one EU member state and another EU member state uncertain. In the judgement’s operative part, the CJEU con-cluded that articles 267 and 344 Treaty on the Functioning of the European Union precludes arbitration clause

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Popular Abstract in Swedish Under de senaste decennierna har en omfattande omstrukturering ägt rum av den psykiatriska vården. Verksamheterna vid de gamla mentalsjukhusen har avvecklats genom en omfattande nerdragning av slutenvårdplatser. Psykiatrins långtidssjuka patienter skulle återföras till det sociala liv de under lång tid varit avskärmade ifrån. I samband med omorganiseringen till den s kIn the past few decades a comprehensive restructuring of psychiatric care has taken place in Sweden. The activities of the traditional closed institutions have been curtailed through a drastic reduction in the number of beds available in such institutions. "Day treatment," has arisen as a new form of intensive outpatient care in the new, geographically localized psychiatric care of patients with l

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Background The endothelial ADP receptor P2Y(1) is responsible for a large part of the reactive hyperemia following cardiac ischemia. Tissue plasminogen activator (t-PA) increases during reactive hyperemia. We postulated that the release of t-PA during reactive hyperemia could be mitigated through blocking the coronary endothelial P2Y(1) receptor. Methods t-PA was measured in peripheral arterial bl

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The decarbonization of the energy-intensive and natural-resourced-based industries is associated with potentially large economic costs. In this paper, I explore how decarbonization may affect the profitability and market value of these industries. I also discuss the possibility of compensating for the investment costs through higher prices and enhanced productivity. I answer these questions using