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PURPOSE: To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association.EXPERIMENTAL DESIGN: Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed

In a strange and awkward way the transition to democracy in South Africa have occurred simultaneously as the HIV/AIDS epidemic firmly and steadily have strengthen its grip around the country. HIV/AIDS have become security a process referred to as securitization. With security theory provided by the Copenhagen School a theoretical framework is constructed discussing the possibilities and pros

The purpose of this study was to examine parenthood of young mothers from a professional point of view. The professionals work in a medium-sized city in Sweden and they represent different professions to give a broad perspective of the subject. The questions in the study were: What were the advantages of being a young mother of today and were there any problems with being a young mother, from the

This essay is about the Northern Ireland Conflict and the Belfast Agreement. Its focus is on the development in Northern Ireland politics after the implementation of the Agreement which was ratified in a referendum. The essay is a case study which analyzes the progress towards an Assembly Government and powersharing between the unionists and the nationalists/republicans. The development is anal

Pay-per-use business models where consumers pay for the unit of service (e.g. a wash) without gaining product ownership are often linked to increased environmental performance. Consumers would become more conscious about consumption patterns and companies would take responsibility for product life cycle issues. Such benefits can only be achieved when the business model is intentionally designed to

Introduction Interstitial lung diseases are characterised by scarring of lung tissue that leads to reduced transfer of oxygen into the blood, decreased exercise capacity and premature death. Ambulatory oxygen therapy may be used to treat exertional oxyhaemoglobin desaturation, but there is little evidence to support its efficacy and there is wide variation in clinical practice. This study aims to

Non-technical summary Agriculture provides many benefits to people, such as producing food and creating jobs in rural areas, but it can also have negative impacts on the environment. We analysed existing monitoring indicators for the European Union’s Common Agricultural Policy (CAP) to evaluate whether the CAP is effectively achieving multiple social and environmental goals. We found that the curr

We investigate the variation of elastic stiffness moduli and the thermodynamic properties of yttrium orthosilicate (Y2SiO5, YSO) under various doping concentrations of Eu3+ ions. The model is based on a low temperature approximation (T<<θD), and the plane-wave density functional theory (DFT) is used to carry out the calculations. The results show that the Eu3+ ions primarily occupy the Y1 site of

The article looks into the multicultural settings of Liviu Rebreanu’s novel “Amândoi” (Both) by briefly examining the representation of its main, minor or incidental characters, either intelligentsia or common people. Ethnicity, social and professional statuses are considered as elements of multiculturalism. The continuous increase of suspense, the open ending, the parody in the undertone, and the

This article presents and discusses the case study “Scraping the surface,” aworkshop about sustainable design held for master’s students of different design majors at the FHNW Academy of Art and Design. Through marketing we, as consumers, are bombarded with products claiming to be sustainable. As a result, sustainability has become a buzz word. “Scraping the surface” highlighted the complex factor

The process of "mineralisation" in biology leads to a diversity of inorganic structures based on silica or calcium carbonate. Some of these are composite and, at the same time, highly crystalline. In all cases a molecular or self assembled "template" species has been identified as the promoter for the crystallisation of the new structure. In biology these "templates" are the end step in the convey

Spin-Echo Modulated Small Angle Neutron Scattering (SEMSANS) in Time-of-Flight (ToF) mode has been shown to be a promising technique for measuring (very) small angle neutron scattering (SANS) signals and performing quantitative Dark-Field Imaging (DFI), i.e., SANS with 2D spatial resolution. However, the wavelength dependence of the modulation period in the ToF spin-echo mode has so far limited th

Mass spectrometry has emerged as a core technique for protein identification and characterization because of its high sensitivity, accuracy, and speed of analysis. The most widespread strategy for studying global protein expression in biological systems employs analytical two-dimensional polyacrylamide gel electrophoresis (2D PAGE) followed by enzymatic degradation of isolated protein spots, pepti

Let T : H 1 × H 2 × H 3 → C be a trilinear form, where H 1, H 2, H 3 are separable Hilbert spaces. In the hypothesis that at least two of the three spaces are finite dimensional we show that the norm square λ = ∥T∥2 is a root of a certain algebraic equation, usually of very high degree, which we baptize the millennia] equation, because it is an analogue of the secular equation in the bilinear case

Additive manufacturing and its related techniques have frequently been put forward as a promising candidate for planetary in-situ manufacturing, from building life-sustaining habitats on the Moon to fabricating various replacements parts, aiming to support future extra-terrestrial human activity. This paper investigates the mechanical behaviour of lunar regolith simulant material components, which

Microembolization is common after coronary interventions, and therefore this MRI study aimed to quantify the effect of coronary microembolization on left ventricular (LV) function. The left anterior descending artery (LAD) was selectively catheterized in an XMR suite (Philips Medical Systems, Best, The Netherlands) in eight pigs to deliver MR contrast media to measure the LAD territory using first

Retinal pericytes play an important role in many diseases of the eye. Immunohistochemical staining techniques of retinal vessels and microvascular pericytes are central to ophthalmological research. It is vital to choose an appropriate method of visualizing the microvascular pericytes. We describe retinal microvascular pericyte immunohistochemical staining in cryo-sections, whole-mounts, and hypot

We study the process of charged polymer translocation, driven by an external electric potential, through a narrow pore in a membrane. We assume that the number of polymer segments, m, having passed the entrance pore mouth, is a slow variable governing the translocation process. Outside the pore the probability that there is an end segment at the entrance pore mouth, is taken as the relevant parame

Although extensively studied (and of large importance for food processing) there is still no general consensus on the time-dependent convective heat transfer coefficient (h) in immersion frying – reported values differ by orders of magnitude (4–7000 W m−2 K−1). Moreover, none of the many methods suggested have become a generally agreed upon standard. This study uses the general uncertainty managem

In order to reduce nitrogen oxides (NOx) and soot emissions while maintaining high thermal efficiency, more advanced combustion concepts have been developed over the years, such as Homogeneous Charge Compression Ignition (HCCI) and Partially Premixed Combustion (PPC), as possible combustion processes in commercial engines. Compared to HCCI, PPC has advantages of lower unburned hydrocarbon (UHC) an