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Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other orthoflaviviruses—enveloped, arthropod-borne RNA viruses—host factors required for TBEV entry remain poorly defined. Here we used a genome-scale CRISPR–Cas9-based
During mammalian ocular development, several signaling pathways control the spatiotemporal highly defined realization of the three-dimensional eye architecture. Given the complexity of these inductive signals, the developing eye is a sensitive organ for several diseases. In this study, we investigated a Dkk1+/- haploinsufficiency during eye development, resulting in coloboma and anterior eye defec
The so-called Substituted Judgment Standard is one of several competing principles on how certain health care decisions ought to be made for patients who are not themselves capable of making decisions of the relevant kind. It says that a surrogate decision-maker, acting on behalf of the patient, ought to make the decision the patient would have made, had the latter been competent. The most common
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Antikroppar, även kallade immunoglobuliner, är proteiner som utgör en viktig del i vårt försvar mot infektioner genom att de kan binda och neutralisera ämnen som uppfattas som främmande, t ex bakterier, virus eller produkter som produceras av dessa organismer. Antikropparna består av en antigen-bindande variabel del som binder till deMany bacteria express immunoglobulin(Ig)-binding proteins that interact with Ig in a non-immune manner. Several of these Ig-binding bacterial proteins have been well characterized and are widely used as reagents for analysis and purification of Ig's. Protein G found on group C and G streptococci has affinity for constant regions of IgG heavy chains, whereas protein L found on Peptostreptococcus ma
Popular science summary: Is RpS6 activation important for leukemia cell progression? Acute Myeloid Leukemia (AML) is the most common acute blood cancer in adults. It is characterized by a rapid increase of leukemic cells in the bone marrow, compromising the development of new blood cells. Despite improvement in treatments and advancements in supportive care, the overall 5-years survival of AML i
Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on
This paper presents analyses on the trends of IS curriculum development that has evolved since its inception from the classical report by the AIS/ACM task force led by Heikki Topi and colleagues published in 2010. Based on an integrated synthesis of the literature, we categorize it into three theoretically-driven dimensions: (i) IS Curricula; (ii) Topic-Based IS Curricula, and (iii) IS Identity Cr
We prove that for k ≫; 4√n regular resolution requires length nω(k) to establish that an ErdÅ's-Rényi graph with appropriately chosen edge density does not contain a k-clique. This lower bound is optimal up to the multiplicative constant in the exponent and also implies unconditional nω(k) lower bounds on running time for several state-of-the-art algorithms for finding maximum cliques in graphs.
In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological significance of this mechanism in vivo remains unclear. Here, we address mitotic retention of the hemogenic factors GATA2, GFI1B and FOS during haematopoietic specifica
Denna uppsats syftar till att undersöka hur nystartade SME:s ser på nyttjandet av molntjänster och om detta är implementerat i företagens IS strategi. Detta görs med hjälp av en sammanställning av litteratur kopplat till ämnet samt en empirisk datainsamling. Den empiriska datainsamlingen består av sju telefonintervjuer med SME:s. Företagen har valts ur ett urval som är avgränsat till företag som a
This paper investigates the challenges of gender mainstreaming in Swedish municipalities, with a focus on the initial implementation. Since the mid-1990s, gender mainstreaming has been the prevailing strategy within Swedish authorities and public administration to increase gender equality in society. In simple terms, this means that a gender equality perspective must be integrated into all decisioThis paper investigates the challenges of gender mainstreaming in Swedish municipalities, with a focus on the initial implementation. Since the mid-1990s, gender mainstreaming has been the prevailing strategy within Swedish authorities and public administration to increase gender equality in society. In simple terms, this means that a gender equality perspective must be integrated into all decisio
Popular Abstract in English At our workplace, at home, and on the road, we rely on software. It has become one of the central technologies on which we base our society. Yet, software is perhaps the major technology that is understood the least by the general population. Most software today is written in languages that requires the programmer to specify not only what is to be achieved, but also hoWriting efficient parallel programs is the biggest challenge of the software industry for the foreseeable future. We are currently in a time when parallel computers are the norm, not the exception. Soon, parallel processors will be standard even in cell phones. Without drastic changes in hardware development, all software must be parallelized to its fullest extent. Parallelism can increase perfor
Blad1 Senast datum Kl Datum t o m System Period Check Checklista inst/fak Information central hantering Länk 11/11/25 Raindance 10 ⃝ Registrera/komplettera intrastatuppgifter. Åtgärda alla poster som har status Ej komplett. Guide 11/25/25 Raindance 11 Bokföringsdag för Statsbudgetanslag – kommer med i saldolistor tidigare 11/25/25 Raindance 11 Bokföringsdag för Primulatransaktioner, kommer med i s
https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2025-11/TIDPLAN-20251113.xlsx - 2026-07-22
Background Low energy availability (EA) in female athletes with or without an eating disorder (ED) increases the risk of oligomenorrhoea/functional hypothalamic amenorrhoea and impaired bone health, a syndrome called the female athlete triad (Triad). There are validated psychometric instruments developed to detect disordered eating behaviour (DE), but no validated screening tool to detect persiste
Project for Doctoral Studies in States of Consciousness (including hypnosis and dissociation) and Parapsychology Project for Doctoral Studies in States of Consciousness and Parapsychology (handledning på svenska eller engelska) As part of programmatic research on states of consciousness and anomalous psychology, my associates and I at the Center for Research on Consciousness and Anomalous Psycholo
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/2017doctoralproject.pdf - 2026-07-22
