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Structure-activity relationships of the estrogenic sesquiterpene ester ferutinin. Modification of the terpenoid core

Esterification of p-hydroxybenzoic acid, a very weak estrogenic compound, with the daucane alcohol jaeschkeanadiol (1b) leads to a spectacular magnification of the estrogenic activity. To identify the structural elements responsible for this effect, the terpenoid core of jaeschkeanadiol p-hydroxybenzoate (ferutinin, 1a) was modified, capitalizing on the presence of two functionalities, the monoacy

Optical Studies and Applications of Single Quantum Dots

The luminescence from single quantum dots has been studied. Single dot photoluminescence was studied under continuous as well as under pulsed excitation. Time-resolved studies revealed fast relaxations in quantum dots. The time resolved measurements were fitted with a set of rate equations. Blinking in the luminescence was observed on a few quantum dots. The polarization of the emission from singl

Flow and turbulence in the discharge stream of different agitators for stirred tanks

In this thesis, the fluid dynamic properties of the conventional Rushton turbine and another impeller type, the Scaba Radial flow Gas dispersing Turbine (with six concave blades) are compared. For comparison, point-wise velocity measurements were made in the discharge of the two turbine types using Hot-Wire Anemometry in constant temperature mode (CTA) with a split film probe. For the time-average

"Dödshugget mot vår nationella tonkonst". Hæffnertidens koralreform i historisk, etnohymnologisk och musikteologisk belysning.

Popular Abstract in Swedish I denna bok undersöks det begynnande 1800-talets svenska reform av kyrkosången. I fokus står J C F Hæffners koralbok 1820, med dess privat utgivna andra del 1821, som här för första gången ägnas en ingående idéhistorisk analys. Hæffners utgåva har kritiserats hårt för att ha tagit död på den s.k. folkliga koralsången — ”dödshugget mot vår nationella tonkonst” — och istäThis thesis analyses the Swedish chorale book in two parts edited by J.C.F. Hæffner in 1820-21 to the new hymnal by Wallin of 1819. This is done in relation to the ideas and practices of the time; earlier and up to present times this chorale style has been described as a “petrified” hymnody, with a rhythmic equalisation, slow tempo, melodic trivialization and harmonic uniformity. To understand th

Silent timber build - modelling acoustic characteristics of timber structures

In year 2017 the WWN+ project "Silent Timber Build" is finishing. The project focused on studying timber structures with regard to their sound insulation characteristics, both airborne sound insulation and impact sound insulation. The aim is to develop calculation models (and / or to provide input to standardized models) for various timber structures available in Europe but also to facilitate futu

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourt

Breast reconstruction with a dermal sling : a systematic review of surgical modifications

A dermal sling (DS) is used to cover the implant with two layers of tissue when immediate breast reconstruction is performed in women with large and ptotic breasts. It works as an autologous acellular dermal matrix/mesh that can be used to control the implant pocket and inframammary fold, without inferring an extra foreign material and higher costs. There is relatively little published about the D

Out-of-hospital cardiac arrest termination of resuscitation with ongoing CPR : An observational study

Introduction: Termination of resuscitation guidelines for out-of-hospital cardiac arrest can identify patients in whom continuing resuscitation has little chance of success. This study examined the outcomes of patients transferred to hospital with ongoing CPR. It assessed outcomes for those who would have met the universal prehospital termination of resuscitation criteria (no shocks administered,

Rheology and shear jamming of frictional ellipses

Understanding and predicting dense granular flows is of importance in geology and industrial applications. Still, most theoretical work has been limited to flows and packings composed of discs or spheres, a narrow subset of all possible packings. To advance our understanding of more realistic flows we here study the granular rheology of ellipses in steady-state flow with a focus on the effects of

Mechanical behaviour of additively manufactured lunar regolith simulant components

Additive manufacturing and its related techniques have frequently been put forward as a promising candidate for planetary in-situ manufacturing, from building life-sustaining habitats on the Moon to fabricating various replacements parts, aiming to support future extra-terrestrial human activity. This paper investigates the mechanical behaviour of lunar regolith simulant material components, which

Magnetic resonance imaging quantification of left ventricular dysfunction following coronary microembolization

Microembolization is common after coronary interventions, and therefore this MRI study aimed to quantify the effect of coronary microembolization on left ventricular (LV) function. The left anterior descending artery (LAD) was selectively catheterized in an XMR suite (Philips Medical Systems, Best, The Netherlands) in eight pigs to deliver MR contrast media to measure the LAD territory using first

Letter to the editor : Indacaterol/glycopyrronium/mometasone furoate compared with salmeterol/fluticasone propionate in patients with asthma: A randomized controlled cross-over study

Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatment delivered via the Breezhaler® device for the treatment of patients with asthma. In this randomized (n = 116), double-blind, double-dummy, active comparator-controlled, three-period cross-o

Metagenomes from coastal marine sediments give insights into the ecological role and cellular features of loki- and Thorarchaeota

The genomes of Asgard Archaea, a novel archaeal proposed superphylum, share an enriched repertoire of eukaryotic signature genes and thus promise to provide insights into early eukaryote evolution. However, the distribution, metabolisms, cellular structures, and ecology of the members within this superphylum are not well understood. Here we provide a meta-analysis of the environmental distribution

Castle and Commerce in Medieval Sweden - the Examples of Stockholm, Borgholm and Piksborg.

The purpose of this paper is to highlight the connection between castles, commerce and urbanity in Scandinavia. This is made by comparing three Swedish royal castles. The castle in Stockholm has its roots in the twelfth or thirteenth century and was founded in connection with the contemporary town. Here are indications that the merchants in an early phase lived in the bailey of the castle. The cas

Improving the groundwater-well siting approach in consolidated rock in Nampula Province, Mozambique

Vertical electrical sounding was used for assessing the suitability of the drill sites in crystalline areas within a water supply project in Nampula Province in Mozambique. Many boreholes have insufficient yield (<600 L/h). Electrical resistivity tomography (ERT) was carried out over seven boreholes with sufficient yield, and five boreholes with insufficient yield, in Rapale District, in an attemp

Fluorine in the Solar Neighborhood : The Need for Several Cosmic Sources

The cosmic origin of fluorine is still not well constrained. Several nucleosynthetic channels at different phases of stellar evolution have been suggested, but these must be constrained by observations. For this, the fluorine abundance trend with metallicity spanning a wide range is required. Our aim is to determine stellar abundances of fluorine for. We determine the abundances from HF lines in i

Quantification and detection of genetic risk factors in the familial aggregation of cancer : Habilitation thesis

SummaryCancer is a multifactorial inheritance disorder caused by a combination of small variations in genes, often acting together with environmental factors. GWASs provide a potential method to investigate the genetic basis of such complex diseases, but they are limited to two main classes of cancer susceptibility variants with different levels of risk and prevalence in the general population: ra

The utopian quest for an alternative

There is no alternative! Margaret Thatcher once proclaimed in order to defend neoliberalist reforms and – implicitly – the capitalist regime. But if one doesn’t agree with Thatcher’s definition of the situation and her (and her many followers’) subsequent analysis, what viable options does one really have? Is it possible to come up with an empirically grounded alternative to the dominant modes of

Healthcare utilisation patterns among older people with intellectual disability and with affective and anxiety diagnoses in comparison with the general population

Objectives: This study investigates specialist healthcare visits of older people with intellectual disability ID having affective and anxiety diagnoses in comparison with the general population, as well as across different levels of ID, behavioural impairment, and living in special housing in Sweden. Method: The study is a retrospective national-register-based study from 2002–2012 of people with I

Characteristics of Patients in Treatment for Alcohol and Drug Addiction Who Succeed in Changing Smoking, Weight, and Physical Activity : A Secondary Analysis of an RCT on Combined Lifestyle Interventions

Introduction: Patients addicted to alcohol or drug often have additional unhealthy lifestyles, adding to the high mortality and morbidity in this patient group. Therefore, it is important to consider lifestyle interventions as part of the usual addiction treatment. Objective: The aim was to identify predictors of successful changes in lifestyle risk factors among patients in treatment for alcohol