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Human embryonic stem cells (hESC) are isolated as clusters of cells from the inner cell mass of blastocysts and thus should formally be considered as heterogeneous cell populations. Homogenous hESC cultures can be obtained through subcloning. Here, we report the clonal derivation and characterization of two new hESC lines from the parental cell line SA002 and the previously clonally derived cell l
Popular Abstract in Swedish INTRODUKTION Aminosyror är en grupp små molekyler som finns i våra celler. Totalt finns det tjugo olika aminosyror, vilka kan binda till varandra i långa kedjor varvid de bildar proteiner (äggviteämnen). Proteiner ansvarar för en lång rad funktioner i organismen och varje cell i en organism måste därför kunna syntetisera ett par tusen olika proteiner för att kroppen ska1-microglobulin is a small glycoprotein present in plasma and in tissues surrounding the gastrointestinal and respiratory tracts. a1-microglobulin is a member of the lipocalin protein family and exhibits several of the typical traits of a lipocalin; it binds an unknown ligand which causes the brown color of the protein, it forms complexes with various different proteins and there have been indica
Abraham från Godegård – berättelsen om en originell människa och hans musik bygger på Peter Berrys mångåriga efterforskningar om folkskolläraren Abraham Hagholm (1811-1890). Hagholm var son till en fattig torpare i en avlägsen socken av Östergötland och drabbades i tidig ålder av förlamning. Hagholm övervann svårigheterna i sitt liv genom sin starka vilja och sitt livslånga engagemang i musik. Ida
This study investigates the association between political trust (an aspect of institutional trust) in the Riksdag (the national parliament in Sweden) and self-reported psychological health, taking generalized (horizontal) trust in other people into account. The 2004 public health survey in Skåne in Southern Sweden is a cross-sectional postal questionnaire study that was answered by 27,757 responde
We discuss the preimaginal development of the mosquito Aedes aegypti from the point of view of the statistics of developmental times and the final body-size of the pupae and adults. We begin the discussion studying existing models in relation to published data for the mosquito. The data suggest a developmental process that is described by exponentially distributed random times. The existing data s
In this paper, enthalpy-entropy compensation (EEC) during the association of two molecules is studied by minimising model systems with molecular mechanics (MM) or quantum mechanics (QM), calculating translational, rotational, and vibrational contributions to the enthalpy and entropy with standard statistical-mechanics methods, using the rigid-rotor harmonic-oscillator approach. We start with simpl
Popular Abstract in Swedish Att bedöma välbefinnande hos patienter med mag/tarmcancer Avhandlingen handlar om undernäring, beroende/oberoende i det dagliga livet och uppfattningar om hälsorelaterad livskvalitet hos patienter som opereras pga cancer i mag/tarmkanalen. Enligt journaldokumentation hos 45 patienter som opererades 1985-89, för cancer i bukspottkörteln, hade patienterna ett försämrat nThe aim was to study some aspects of patients´ well-being, related to nutrition, activities of daily living and health related quality of life, when undergoing major gastrointestinal cancer surgery. Chart documentations (N=45) of patients undergoing subtotal pancreatectomy were studied, and showed the patients' well-being to be affected, although it was not possible to fully evaluate the results o
The main objective was to assess knowledge, practices, and restrictions faced by young women regarding their menstrual hygiene. The views of adult women having young daughters were also included and both views were compared. In addition, the factors influencing the menstrual hygiene practices were also studied. The study was carried out during 2008 in Mumbai, India. The mixed methods approach was
The subject of this thesis is protein dynamics. Papers I--IV and VI study either of two different processes: mechanical unfolding and aggregation. Paper V presents a computationally efficient all-atom model for proteins, variants of which are used to perform Monte Carlo simulations in the other papers. Mechanical unfolding experiments probe properties of proteins at the single molecule level. The
Despite the fact that caring has been regarded as the core of nursing for decades, our knowledge about caring is still mainly on a philosophical level. The problem with these philosophical descriptions is that they do not serve as explicit guides for today's nurses, particularly in the light of the considerable changes that have taken place in the healthcare sector. One of the aims of this thesis
Popular Abstract in Swedish Mycken möda har under de senaste årtiondena lagts ner på forskning om försurande utsläpp och dess skadliga effekter på skogar, vattendrag och människor. Kritiska belastningsgränser, i folkmun kallat "vad naturen tål", har tagits fram och använts i europeiska förhandlingar om utsläppbegränsningar. För skogsekosystem baseras de kritiska belastningsgränserna för försurandeAcidification caused by emissions of Nitrogen and Sulphur and associated adverse effects on forest ecosystems has been an issue on the political agenda for decades. Temporal aspects of soil acidification and/or recovery can be investigated using the soil chemistry model SAFE, a dynamic version of the steady-state model PROFILE used in critical loads assessment on the national level, e.g. for Swede
Hylander treated 144 species of Hieracium sect. Hieracium found in Scandinavian parks, 132 of which were described for the first time. However, he did not supply any determination key, only a few species were illustrated and hints about the differences between species were few. In addition, the species concept of Hylander was obviously much narrower than what has been agreed upon by those working
Marginalised agrarian societies are suggested to be the most vulnerable to environmental hazards and other perturbations. There are competing explanations for this phenomenon, which include: a lack of development, global environmental change, and the development process itself, or capitalism more specifically. All three causal arguments are compelling, but typically offer only partial explanations
Structural variants (SVs) rearrange large segments of DNA1 and can have profound consequences in evolution and human disease2,3. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly reliant on genome sequencing, population references such as the Genome Aggregation Database (gnomAD)4 have become integral in the interpretation of single-nucleotide v
In this analytical chapter we focus on human factors to shed light on what a 21st-century project might look like from within. Adopting a non-essentialist perspective to project-making, we at the same time acknowledge that the notion of human nature is blurred, dynamic, changeable, heterogeneous, and internally riven. The human condition, hence, always dictates what ontological position a project
Using an isolated Milky Way-mass galaxy simulation, we compare results from nine state-of-the-art gravito-hydrodynamics codes widely used in the numerical community. We utilize the infrastructure we have built for the AGORA High-resolution Galaxy Simulations Comparison Project. This includes the common disk initial conditions, common physics models (e.g., radiative cooling and UV background by the
A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density
In this work, we experimentally report the figures of merit of state-of-the-art heterostructure Tunnel Field-Effect-Transistor (TFET) arrays from room (300K) down to cryogenic temperature (10K) at supply voltages below 400mV. We demonstrate here, for the first time, that InAs/InGaAsSb/GaSb Nanowire (NW) TFETs are robust enough to maintain e
