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Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding pro
Adaptive spectral estimation techniques are known to provide good spectral resolution and contrast even when the observation window (OW) is very short. In this paper two adaptive techniques are tested and compared to the averaged periodogram (Welch) for blood velocity estimation. The blood power spectral capon (BPC) method is based on a standard minimum variance technique adapted to account for bo
Pinus sylvestris L. seedlings were grown in the laboratory in a forest humus which had been treated with different levels of CaO to give a soil pH gradient from 4 to 7. After 12 and 15 wk the resulting ectomycorrhizal infection was classified according to macroscopical morphology. The uniformity of the infection types distinguished was evaluated by isolating the fungi from the root tips and infect
Uptake of P(P-32) and Ca(Ca-45) by seedlings of Picea abies (L.) Karst and Betula pendula Roth, non-mycorrhizal or mycorrhizal with Paxillus involutus (Batsch: Fr) Fr. was studied. Seedlings were grown in unamended peat (pH 4.0) or in peat limed (CaO) to pH 5.1 or 6.1. A double-labelled (P-32 and Ca-45) complete nutrient solution was added to the peat 7 wk after planting. An 8 d period was allowed
Arbuscular mycorrhizal (AM) fungi depend on a C supply from the plant host and simultaneously provide phosphorus to the colonized plant. We therefore evaluated the influence of external P on C allocation in monoxenic Daucus carota-Glomus intraradices cultures in an AM symbiosis. Fungal hyphae proliferated from a solid minimal medium containing colonized roots into a C-free liquid minimal medium wi
In many gel applications the swelling and shrinking kinetics are very important, e.g. in controlled/slow release, where the kinetics determine the rate of out-diffusion of the active component, and in gel extraction where the gel is swollen and shrunk several times. In this study swelling kinetics of poly(N-isopropylacrylamide) gel (NiPAAm gel) was determined by monitoring the swelling process usi
Objectives: Capillary damage is a characteristic feature of systemic sclerosis (SSc). This work aimed to explore the potential clinical value of simple microscopic counting of capillary density. Methods: In 325 patients admitted because of a clinical suspicion of SSc and in 80 healthy controls, nailfold capillary microscopy (NCM) was performed using a stereo-zoom microscope in 20x magnification an
The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly reducing infarct size induced by transient middle cerebral artery occlusion (MCAO)
Popular Abstract in Swedish Winnicott definierade och införde begreppen övergångsobjekt (ÖO) och övergångsfenomen (ÖF) vid ett möte i brittiska psykoanalytiska föreningen i maj 1951. Detta kopplades till ett tänkande, som gällde utvecklingen av barnets relaterande från en från början alltigenom subjektiv upplevelsevärld till en värld med ”verkliga” relationer - och talade om ”the intermediate areaThe central issue of the dissertation is the place and meaning of the concepts transitional object (TO) and transitional phenomenon (TP) as defined by Winnicott, in a normal psychological context. A group of children were followed from age 8 months to 6 years. A prevalence study was carried out by interviewing parents in connection with the child's (n=147) routine check-ups at the Child Health Cen
Steel girders require stability controls for different construction stages before the lateral-torsional support from the concrete deck occurs. The load-carrying capacity of bridge girders and bracing forces generated in their bracings are very sensitive to the girders' initial imperfections in terms of both the magnitude and distribution along the span. Relatively little knowledge is available in
Postnatal intestinal development is a very dynamic process characterized by substantial morphological changes that coincide with functional adaption to the nutritional change from a diet rich in fat (milk) to a diet rich in carbohydrates on from weaning. Time-resolved studies of intestinal development have so far been limited to investigation at the transcription level or to single or few proteins
BACKGROUND: A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the ratio between somatic and germline BRCA1/2 mutations in unselected breast cancer patients are currently unclear.PATIENTS AND METHODS: Paired normal and tumor DNA was analyzed for BRCA1/2 mutations by massively parallel seque
Textbooks in applied mathematics often use graphs to explain the meaning of formulae, even though their benefit is still not fully explored. To test processes underlying this assumed multimedia effect we collected performance scores, eye movements, and think-aloud protocols from students solving problems in vector calculus with and without graphs. Results showed no overall multimedia effect, but i
Phosphorus (P) eutrophication of lakes and streams, coming from drained farmlands, is a serious problem in areas with intensive agriculture. Installation of P sorbing filters at drain outlets may be a solution. Efficient sorbents to be used for such filters must possess high P bonding affinity to retain ortho-phosphate (Pi) at low concentrations. In addition high P sorption capacity, fast bonding
Understanding the mechanisms that govern the combustion processes is important for being able to further increase the efficiency ofcombustion devices. Temperature is considered to be one of the most important parameters controlling the progression and finalproducts of combustion. Regulating the temperature in combustion devices enables higher degrees of efficiency to be achieved. Theengine compone
Popular Abstract in Swedish Vid extern strålbehandling används en s.k. linjäraccelerator för att producera och leverera den önskade strålningen till cancertumörer. I linjäracceleratorn accelereras elektroner till nära ljusets hastighet och styrs sedan mot en metalplatta där de bromsas upp och genererar bromsstrålningsfotoner (högenergetisk röntgenstrålning). Intensiteten av den strålning som sändsThe aim of this work was to investigate the dosimetric effects of removing the flattening filter from conventional C-arm medical linear accelerators. In conventional linear accelerators used for radiotherapy, a flattening filter is positioned in the beam line to provide a uniform lateral dose profile at a specified depth in water. However, for some radiotherapy treatments, a uniform lateral dose p
Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. Targeting this pathway is very important when it comes to understanding intracellular signaling and also for developing drugs for treating diseases associated with
Popular Abstract in Swedish Alla levande organismer måste kunna anpassa sig till förändringar i sin omgivning, såsom kyla, värme eller torka. Vid sådana förändringar tar enskilda celler emot signaler ifrån sin omgivning via särskilda s.k. receptorproteiner på cellytan. Receptorproteinerna skickar signalerna vidare in i cellen, där de kan ge upphov till en kedja av processer, vilka slutligen leder Phosphoinositides (PIs) play major roles in cell signal transduction. Although it is clear that PIs are important components also in plant signalling, little is known about their roles in plant cells, compared to animal cells. This thesis describes work on two PI-dependent enzymes involved in plant intracellular signalling, phosphoinositide-specific phospholipase C (PI-PLC) and 3-phosphoinositide
The importance of the home environment increases with age. Perceived aspects of home influence life satisfaction, perceived health, independence in daily activities and well-being among very old people. However, research on health and perceived aspects of home among senior citizens in earlier phases of the aging process is lacking. Therefore, the main aim was to explore whether perceived aspects o
