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Background: Few studies have investigated the 24-hour symptom profile in patients with COPD or how symptoms during the 24-hour day are inter-related. This observational study assessed the prevalence, severity and relationship between night-time, early morning and daytime COPD symptoms and explored the relationship between 24-hour symptoms and other patient-reported outcomes. Methods: The study enr

Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke a

An outbreak of suspected contact dermatitis among subway construction workers was suspected to be due to a new bisphenol A/F-based epoxy resin system (ERS). The construction workers used ERSs during the insertion of iron bars into concrete walls. The objective of the study was to determine the components (if any) of the ERS responsible for the contact allergy. Patch testing was performed on 20 of

In this article the organization and functional details of the extracellular matrix, with particular focus on cartilage, are described. All tissues contain a set of molecules that are arranged to contribute structural elements. Examples are fibril-forming collagens forming major fibrillar networks in most tissues. The assembly process is regulated by a number of proteins (thrombospondins, LRR-prot

Popular Abstract in Swedish När en organism utsätts för stress, t. ex. vid hög temperatur, starkt solljus, torka eller köld, produceras särskilda hjälpar-proteiner, s. k. ¨stress-proteiner¨. Syntesen av cellens normala proteiner stängs av och istället produceras bara stress-proteiner. Dessa stress-proteiner är till för att skydda andra protein som skadas under stress. De s. k. ¨värme-stress¨ proteA specific group of heat shock proteins, the so called small heat shock proteins (sHsps), exists in all organisms but are especially abundant in plants. The sHsps prevent aggregation of other proteins (substrate proteins) during transient heat and oxidative stress. Molten globule forms of the substrate proteins are kept in a re-folding competent state by binding onto the outer surface of the sHsp.

BACKGROUND/AIMS: The pathophysiology of acute pancreatitis (AP) may be studied using markers of protease activation (active carboxypeptidase B (aCAP), the activation peptide of carboxypeptidase B (CAPAP)), leakage of pancreatic enzymes (trypsinogen-2, procarboxypeptidase B (proCAP), amylase), and inflammation (monocyte chemoattractant protein-1 (MCP-1), CRP). METHODS: This prospective study includ

The affinity and enantioselectivity have been determined for designed propranolol derivatives as ligands for Cel7A by capillary electrophoresis (CE) at pH 7.0. These results have been compared to measurements at pH 5.0. In agreement with previous studies, the affinity increased at the higher pH. However, the affinity was not as dependent of the ligand structure at pH 7.0 as at pH 5.0, and the sele

In our everyday life we live distant from the origin of life itself - nature. Dramatic landscape and fascinating views touch us in a way that few other things manage to do. It is something that make us recognize our powerlessness and the feeling of awe towards the nature. Experiencing striking nature is a way to create a deeper understanding of our own world and at the same time enrich our lives w

The purpose of this thesis is to examine the views of internet stakeholders in Sweden, from the perspective of net neutrality. There does not exist one single definition of the principle, which makes defining net neutrality in the context of this thesis important. The basic concept of net neutrality is that all similar internet content should be treated equally. However there are several technical

Besittningsbegreppet är och har länge varit ett centralt begrepp inom den svenska sakrätten. Begreppet är avgörande i många fall, men saknar trots detta en reell definition. Inom sakrätten är besittning ett viktigt rättsfaktum som både presumerar äganderätt och skänker förfogandelegitimation. Detta märks framförallt när det handlar om tre typiska sakrättsliga problemsituationer: tvesala, godtrosföThe concept of possession is and has long been a central concept of the Swedish property law. Being a crucial and important concept, it has none the less never been fully defined by Swedish law. Possession is an important element of property law; being in possession of personal property means one is presumed to own the property or, at least, use the property. This becomes obvious when one looks at

The phase center is defined as the point on an antenna from which the far field radiation seems to originate. Phase center calculations are often uncertain and vague, and very little concrete information is available on the subject. Recently, a replacement parameter called the radiation center was introduced in [5]. The radiation center is more rigorously defined than the phase center and possesses a

Addressing key environmental concerns during humanitarian assistance is critical to prevent additional hazards, reduce risks, and to not further increase the vulnerability of disaster-affected populations. However, the environment remains an underappreciated cross-cutting issue within the humanitarian sector and efforts to systematically integrate environmental concerns into humanitarian assistanc

Gig-ekonomins intåg på den svenska arbetsmarknaden har väckt många arbetsrättsliga frågor. Den här uppsatsen behandlar en av de frågorna, nämligen hur de traditionella arbetstagar- och arbetsgivarbegreppen står sig inom ramen för gig-ekonomin. Att det uppkommer arbetsrättsliga problem vid tillämpningen av begreppen beror på att den rättsliga utgångspunkten för arbetsrättens tillämpningsområde är eThe rise of the gig economy in the Swedish labour market has lead to several legal questions concerning labour law. This essay aims to discuss one of these questions, namely how the traditional concepts of employee and employer are holding up in the gig economy. The reason for this legal issue is that the overall departure of the applicability of Swedish labour law is a bilateral labour market wit

I denna studie utvärderades tre metoder för att utvinna DNA ur bakterier från sex personers tarmflora. Slutsatsen blev att kit extraktionen var den bästa metoden, men att personen som provet kom ifrån påverkar resultaten mer än själva metoden i sig. Celiaki är en så kallad autoimmun kronisk sjukdom vilket innebär att immunförsvaret angriper tarmens slemhinna som ett gensvar på absorberat gluten. GCeliac disease is a chronic autoimmune disease which affects about 3 % of children in Sweden where most of them have an asymptomatic form making it difficult to detect. The bacterial composition in the gastrointestinal microflora can affect the intestinal barrier properties and the immune systems response to various dietary components. An unfavourable composition of the microflora can activate par

Sex matters! It is natural to ask questions about where the species of this planet come from and how they become what they are. As a matter of fact, development of new species is in process all the time. Somebody named this process speciation. Like language which enables us to guess where the people might come from, some traits make it possible to recognize the individuals from the same populatio

This Master’s project presents on the angular dependence of the intensity of the Raman active phonon modes of Black Phosphorus (BP), a layered 2D material with unique and attractive characteristics to the scientific and engineering community. Raman spectroscopy is an indispensable tool in quick and unobtrusive analysis of chemical structures. In this Master project, the structure of BP is analyzed

Pallets are the most common tertiary packaging solution with over 80% the world trade currently being carried out using pallets. The most widely used pallet type is the four-way wood pallet which accounts for 86% of the pallet production worldwide and the most common pallet size is the Euro Pallet. A department at Tetra Pak called Additional Materials (AddMat) is mainly using Euro Pallets, which h