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BACKGROUND: Despite pain control being a top priority in end-of-life care, pain continues to be a troublesome symptom and comprehensive data on pain prevalence and pain relief in patients with different diagnoses are scarce.METHODS: The Swedish Register of Palliative Care (SRPC) was used to retrieve data from 2011 to 2022 about pain during the last week of life. Data were collected regarding occur
The aim of the study reported in this paper is to investigate how students understand continuity and differentiability during and after a calculus course. The students’ choices of representations, both claimed and acted, were also studied. The study is part of a larger study of four student groups taking a calculus course. 207 students answered a questionnaire during the course and of them, 11were
Objective: To determine the diagnostic accuracy of prenatal ultrasound in detecting coarctation of the aorta (CoA). Methods: An individual participant data meta-analysis was performed to report on the strength of association and diagnostic accuracy of different ultrasound signs in detecting CoA prenatally. MEDLINE, EMBASE and CINAHL were searched for studies published between January 2000 and Nove
Background: There is almost no data on the combined associations between apolipoprotein E gene (APOE) genotypes, trace elements (TEs), and lipid peroxidation in vivo. The aim of our study was to evaluate the association between APOE genotypes and TE levels in blood (B-TEs) and erythrocytes (E-TEs), and 8-isoprostane in urine (U-8-isoprostane) in women with low exposure to potentially toxic TEs and
Background: Despite a good prognosis, survivors of differentiated thyroid cancer (DTC) may have reduced health-related quality of life (HRQOL) many years after treatment, and it is unclear how suppression of thyroid-stimulating hormone (TSH) may contribute to HRQOL. This study investigated changes in HRQOL in the 5 years following DTC treatment, the association between HRQOL and TSH suppression, a
Introduction: There are few large registry-based studies comparing disease prevalence among people with intellectual disabilities (ID) compared to general populations, despite older people with ID having more comorbidities and health care utilization. This study aimed to explore differences in prevalence of dementia and age at first diagnosis between people with ID and the general population in Sk
Objective: To evaluate the long-term performance of the patch materials we have used to augment the pulmonary arterial tree across a wide spectrum of diagnoses and anatomical locations. Methods: Retrospective, single-center review of 217 consecutive pediatric patients at a tertiary referral center from 1993 to 2020 who underwent patch arterioplasty of the pulmonary arterial tree from the pulmonary
När forskare blickar ut i universum ser de överallt spåren av en stor mängd osynlig massa. Massan finns där men det går inte att se den. Ungefär 80% av all massa i universum beräknas bestå av denna "mörka materia". Det är som att mänskligheten står på stranden och blickar ut över havet utan att veta vad vatten är. I partikelfysik studeras universums minsta beståndsdelar, elementarpartiklarna, för The high event rate delivered by the Large Hadron Collider (LHC) provides experiments with opportunities for new discoveries as well as challenges related to the large amounts of data recorded. Overcoming this requires innovative techniques in the three topics of this thesis: Data acquisition, data analysis, and data compression.In the data taking period of 2015-2018, the ATLAS experiment received
Background: Concern was raised within the International Contact Dermatitis Research Group (ICDRG) regarding the scoring of weak allergic versus doubtful patch test reactions. Objective: To investigate the degree of uniformity in patch test reading. Methods: Five series of fictive contact dermatitis cases were written up by the study organizer and presented to expert participants. Each series was s
Phylogenies are central to many disciplines in biology. While disciplines such as systematics are focused on phylogenetic hypotheses themselves, other disciplines depend on robust and well-supported phylogenies in order to put biological data into evolutionary context through phylogenetic comparative studies. Examples of such fields are macroevolutionary research e.g. studying the evolution of a f
PURPOSE – Comparative studies demonstrate that patients who use electronic patient-reported outcomes (ePROs) experience better outcomes; however, research comparing ePRO designs to determine optimal strategies for routine clinical practice is limited. We aimed to determine the impact of a novel checkbox format for presenting items in a postoperative symptom-assessment ePRO tool.METHODS – Patients
BackgroundPatients with chronic right ventricular (RV) pacing are at an increased risk of heart failure. Previous studies have indicated that cardiac resynchronization therapy (CRT) is underused in this setting, and that there may be sex-based differences in both CRT use and clinical outcome.ObjectiveTo evaluate sex-based differences in CRT use and clinical outcome for patients with new-onset hear
Background: Hospital-acquired hyponatremia remains a feared event in patients receiving hypotonic fluid therapy. Our objectives were to assess post-operative plasma-sodium concentration and to provide a physiological explanation for plasma-sodium levels over time in children with acute appendicitis. Methods: Thirteen normonatremic (plasma-sodium ≥135 mmol/L) children (8 males), median age 12.3 (IQ
Aims/hypothesis: The rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin secretion (GSIS), emphasising the role of beta cell dysfunction in the early stages of the disease. In search of novel mechanisms of beta cell dysfunction after long-term exposure to mild to severe glucotoxic conditions, we extensively characterise
This thesis work concerns studies of two rare-earth-ions, praseodymium (Pr3+) and europium (Eu3+), doped into a yttrium orthosilicate (Y2SiO5) crystal for applications in quantum computing. The nuclear spin levels of these ions can have very long coherence times, up to several hours. Coherence can also be effectively transferred between the optical and hyperfine levels. These systems, therefore, h
Background: Unfractionated heparin (UFH) is frequently administered before percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Aims: The aim of the study was to investigate if pretreatment with UFH prior to arrival at the catheterisation laboratory affects coronary artery occlusion, mortality, and in-hospital major bleeding in patients with
Background: Atopic dermatitis (AD) is a complex disease with variations in severity and healthcare utilization. Examining patient pathways through analyses of longitudinal patient data provides an opportunity to describe real-world clinical patient care and evaluate healthcare access and treatment. Objective: To describe longitudinal care pathways including health care management, treatment patter
ObjectivesDiet has received attention as a factor possibly contributing to the development of Rheumatoid arthritis (RA). Several dietary exposures have been examined in various populations using different diet assessment methods. The aim of this study was to systematically assess the literature on the relation between dietary patterns, different food and food groups, macronutrients, non-alcoholic
The Klotho (KL) gene is involved in phosphate homeostasis. Polymorphisms in this gene have been reported to be associated with the risk of cardiovascular disease. Here we used computational tools to predict the damage-associated single nucleotide polymorphisms (SNPs) in the human KL gene. We further investigated the association of SNPs in the KL gene and mortality in the Swedish multicenter prospe
