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Introduction: The aim was to investigate whether the stem cell marker LGR6 has prognostic value in colon cancer, alone or in combination with the prognostic biomarkers CEA and CXCL16. Methods: LGR6 mRNA levels were determined in 370 half lymph nodes of 121 colon cancer patients. Ability to predict relapse after curative surgery was estimated by Kaplan-Meier survival model and Cox regression analys

Context. Stars tend to form in clusters, but many escape their birth clusters very early. Identifying the escaped members of clusters can inform us about the dissolution of star clusters, but also about the stellar dynamics in the galaxy. Methods capable of finding escaped stars from many clusters are required to fully exploit the large amounts of data in the Gaia era. Aims. We present a new metho

STUDY QUESTION: Can the alleged association between ovarian endometriosis and ovarian carcinoma be substantiated by genetic analysis of endometriosis diagnosed prior to the onset of the carcinoma?SUMMARY ANSWER: The data suggest that ovarian carcinoma does not originate from ovarian endometriosis with a cancer-like genetic profile; however, a common precursor is probable.WHAT IS KNOWN ALREADY: End

Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population. Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC).

The ACMG/AMP guidelines include five categories of which variants of uncertain significance (VUSs) have received increasing attention. Recently, Fowler and Rehm claimed that all or most VUSs could be reclassified as pathogenic or benign within few years. To test this claim, we collected validated benign, pathogenic, VUS and conflicting variants from ClinVar and LOVD and investigated differences at

Purpose: A pilot study to identify bacterial biofilm in the lacrimal sacs of patients with chronic dacryocystitis, and in patients with epiphora but without discharge, using scanning electron microscopy. Methods: Five patients: two with nasolacrimal duct obstruction without dacryocystitis, and three with dacryocystitis refractory to antibiotics, underwent external dacryocystorhinostomy. One contro

Flooding is one of the main social impacts in urban areas, especially in larger, densely impermeable cities. Therefore, developing studies capable of identifying areas that are vulnerable to this type of event is crucial to provide early warning and a quick and effective response to reduce damages. Thus, this study sought to identify areas vulnerable to flood in the Igapó Lake Basin, a densely urb

The paper deals with numerical investigations of load-bearing capacity and fracture behaviour of Cross Laminated Timber at in-plane shear loading. Focus is on shear failure mechanism III, i.e. failure in the crossing areas between flatwise bonded laminations, and on evaluating test methods for that failure mode. In current design provisions, this failure mode is characterised by the rolling shear

Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM are still limited. Here, we have generated and characterized novel human telomerase reverse transcriptase (hTERT)-transduced mesothelial cell and mesothelioma-associated fibroblast (Meso-CAF) models and investigated their impact on PM cell gr

The cleaning process of the bimetallic Pt3Sn(111) surface has been studied by means of low-energy electron microscopy (LEEM), microspot low-energy electron diffraction (μ-LEED), and X-ray photoemission electron microscopy (XPEEM). Different cleaning procedures, performed under ultra-high vacuum conditions (UHV), including sputtering with argon ions and repeated cycles of annealing up to 1500 K wer

Anion exchange membrane water electrolysis (AEMWE) has a great potential to be established as a high-performance and low-capital cost technology for hydrogen production. High current densities can be achieved with non-platinum group metal (non-PGM) catalyst. However, the harsh operation conditions require stable cell components. Here, we report on the use of a highly stable and ion conductive poly

Introduction: The sixth Åland Islands Conference on von Willebrand disease (VWD) on the Åland Islands, Finland, was held from 20 to 22 September 2018. Aim: The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD. Results and discussion: The topics covered both clinical aspects of disease management, and biochemical and labora

Background and purpose — Information on outcomes after some modern total ankle replacement (TAR) designs is scarce. We therefore examined outcomes after trabecular metal (TM) TAR in Sweden by use of data from the national registry. Patients and methods — On December 31, 2020, 239 primary TM TARs had been reported to the Swedish Ankle Registry. We analyzed prosthesis survival probability, using exc

GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in the brain of`DRD patients and correlate this to (non-)motor symptoms. Dynamic [11C]DASB PET scans, a marker

Photonic materials for high-temperature applications need to withstand temperatures usually higher than 1000 °C, whilst keeping their function. When exposed to high temperatures, such nanostructured materials are prone to detrimental morphological changes, however the structure evolution pathway of photonic materials and its correlation with the loss of material's function is not yet fully underst

Denna studie syftar undersöka hur och med vilka intentioner hållbarhet integreras och implementeras av organisationer i en delningsekonomisk kontext. Vidare ämnar studien bidra till fältet för hållbarhetsvarumärkning, där föga forskning har utförts med avsikt att sammanbinda hållbarhetsvarumärkning med delningsekonomi. Tolv semistrukturerade intervjuer med VD:s och marknadsansvariga utfördes med sThis study intends to explore how and with what intentions organisations within a sharing economy context choose to integrate and implement the concept of sustainability. It further aims to contribute to the field of sustainability branding, where very limited research has been carried out in regards of sustainability branding within a context of sharing economy. Twelve semi-structured interviews

This thesis is a meta-evaluation of a specific evaluation; "Demokrati och delaktighet? Delrapport om Storstadssatsningen i Fosie, Hyllie och Södra Innerstaden" . My thesis concerns two of the three district city councils mentioned in the title, in the City of Malmö, and their way of handling the government initiative Storstadssatsningen. The initiative is aiming to promote strategies to

The purpose of our essay, was to examine how it's like for a child growing up with a psychiatric disordered parent. We have chosen to see this from two perspectives, the professionals who meet children with a psychiatric disordered parent in their work, and now grown-up children who have own experience of this. Our questions were: - How did the childhood with a psychiatric disordered parent lo