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Secondary prevention and lifestyle indices after stroke in a long-term perspective

OBJECTIVES: To describe the long-term perspective regarding prevalence of risk factors, secondary stroke prevention, and lifestyle indices after stroke.METHODS: From a population-based one-year cohort (n = 416), we performed an observational study of 145 survivors at 16 months and 10 years after stroke (age 27-97 years) regarding secondary prevention including reaching acceptable treatment goals;

The physiological and emotional effects of touch : Assessing a hand-massage intervention with high self-critics

Research demonstrates that highly self-critical individuals can respond negatively to the initial introduction of a range of therapeutic interventions. Yet touch as a form of therapeutic intervention in self-critical individuals has received limited prior investigation, despite documentation of its beneficial effects for well-being. Using the Forms of Self-Criticism/Self-Reassuring Scale, 15 high-

Reduced ability to produce reflex-evoked neurogenic inflammation, a sign of decreased defense against COVID-19 infection?

Background: A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?. Materials and methods: Histamine SPT

The Bush Doctrine - a carte blanche for a war on the world?

The events on September 11, 2001, changed the view for many regarding the use of force. The US immediately engaged in a war against terrorism, and in an attempt to win this war and protect American citizens, President Bush and his administration used all means necessary. Thus, the Bush Doctrine came to be. This doctrine introduced a controversial view of the use of force. It would allow the US to

Medicinsk limning av lungsäcken

A statistical analysis has been performed on a pharmacological study from the Lung department of Medical clinic, UsiL. The intention of the study was to explore, especially from a pallative aspect, treatment of exceptional fluid manifestations in pleura caused by cancer. The patients were recruited between 1993 and 1997. They were randomized either to the drug Atabrine or to the drug Bleomycin. Ho

Energy Crops: Stakeholder Identification and Analysis - A Case of Belarus

Belarus is subject to serious energy security issues due to limited domestic energy resources; a low diversity in the national energy profile, significant depreciation of capital assets in the Belarusian energy system, a high share of energy resources import, and a dominating dependence on one energy importer The Russian Federation. In response to these issues the country is very interested in div

Immunogenetics of Parkinson's disease: Translational studies from rodents to humans

Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. Mutations in si

Pebble-isolation mass : Scaling law and implications for the formation of super-Earths and gas giants

The growth of a planetary core by pebble accretion stops at the so-called pebble isolation mass, when the core generates a pressure bump that traps drifting pebbles outside its orbit. The value of the pebble isolation mass is crucial in determining the final planet mass. If the isolation mass is very low, gas accretion is protracted and the planet remains at a few Earth masses with a mainly solid

Radiation Doses Received by Major Organs at Risk in Children and Young Adolescents Treated for Cancer with External Beam Radiation Therapy : A Large-scale Study from 12 European Countries

Purpose: Childhood cancer survivors, in particular those treated with radiation therapy, are at high risk of long-term iatrogenic events. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. We aimed to set up a standardized organ dose table to help former pati

Fibroblast subsets in non-small cell lung cancer : associations with survival, mutations, and immune features

BACKGROUND: Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer both anti- and pro-tumorigenic functions. Prior in situ profiling studies of human CAFs have largely relied on scoring single markers, thus presenting a very limited view of their molecular complexity. Our objective was to study the complex

Delayed vascular complication after collagenase injection for Dupuytren disease

Background: Vascular adverse events after collagenase injection for Dupuytren disease are absent in large trials and systematic reviews. The aim of this study is to present a case series of delayed vascular complications after collagenase treatment. Methods: A prospective evaluation of 1181 consecutively treated patients at one orthopedic department identified three patients reporting symptoms of

Large-Eddy Simulations of Thermal Ribbed Duct Flows

Ribbed channel flows are encountered in numerous engineering applications to promote turbulence and enhance heat transfer in various cooling passages, e.g., in turbine blades and at combustor walls. Numerical simulations have become an increasingly useful tool for providing insights into complex turbulence and flow separation, which are critical to the design and optimization of such channels. In

Cumulative live birth rate after IVF : Trend over time and the impact of blastocyst culture and vitrification

STUDY QUESTION: Has cumulative live birth rate (CLBR) improved over time and which factors are associated with such an improvement? SUMMARY ANSWER: During an 11-year period, 2007-2017, CLBR per oocyte aspiration increased significantly, from 27.0% to 36.3%, in parallel with an increase in blastocyst transfer and cryopreservation by vitrification. WHAT IS KNOWN ALREADY: While it has been shown that

Conservation-focused mapping of avian migratory routes using a pan-European automated telemetry network

Accelerated biodiversity loss has destabilized functional links within and between ecosystems. Species that cross different ecosystems during migration between breeding and nonbreeding sites are particularly sensitive to global change because they are exposed to various, often ecosystem-specific, threats. Because these threats have lethal and nonlethal effects on populations, many migratory specie

Fire-induced radiological integrated assessment : aerosol characterization

This report on detailed aerosol characterization of fire smoke emissions is part of the Fire-Induced Radiological Integrated Assessment (FIRIA; CERN, Switzerland). In this study, carried out at Lund University, a number of materials were combusted in a cone calorimeter at varied heat fluxes. In a few experiments, the effect of reduced O2 content of supply air was investigated (vitiated conditions)

Lessons from single-cell RNA sequencing of human islets

Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysfunction have been put forward but many important questions still remain. Furthermore, our understanding of the contribution of each islet cell type in