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Biological pharmaceuticals are the answer to many severe diseases of today’s society. Some of these are protein-based drugs and can be produced from human blood plasma. In order to guarantee the safety of patients, absence of any pathogens needs to be ensured. Such a pathogen is HIV-1, which holds high mutation rate and a large variation in its genome. The aim of this project was to develop novel
El Niño-Southern Oscillation (ENSO) affects weather and climate in regions spread all around the Earth via teleconnections. While quite a lot of research has been done on recognizing what regions are affected by these and what is the sign of the associated temperature, rainfall and vegetation anomalies, not that much attention has been paid to the timing of the impacts with respect to the ENSO sta
Denna studie är gjord i samråd med en gymnasieskola i södra Sverige. Studien berör hur gymnasieelever ser på sin framtid i ljuset av pandemin Covid-19. Den empiriska undersökningen utfördes genom en tvärsektionell enkätundersökning som fanns tillgänglig för eleverna under två veckors tid. Undersökningen är grundad i Theory of planned behavior och de konstrukt som undersöks utgår ifrån Intention, AThis study was conducted alongside a high school in the south of Sweden. The study explores senior students perspective on their future in the light of the Covid-19 pandemic. The empirical material was collected through a cross-sectional online survey, available to the students during a 14 day period. This study is based in the Theory of planned behavior and the constructs that are examined in th
Functional assessment of SAMD9/SAMD9L proteins in cell cycle progression Myelodysplastic syndromes (MDS) are one of the most neoplasms resulting in defective generation of blood cells. Chromosomal abnormalities are common in MDS, with deletions of chromosome 5 being the most common aberration adult patients while deletions of chromosome 7 are most common in childhood MDS. MDS with loss of chromos
I detta examensarbete granskades värmeöverföringen mellan två zoner i en bubblande fluidiserad bädd och det resulterande temperaturfältet med numeriska strömningsberäkningar av en laminär Euler-Euler-tvåfluidbeskrivning. Syftet var att uppskatta den termiska potentialen att flerstega en kraftvärmepanna genom integrering av en kommunicerande förgasningsreaktor som utnyttjar värme från förbränningenIn this Master's thesis, the heat transfer between two zones in a bubbling fluidized bed and the resultant temperature field were examined using a laminar Eulerian-Eulerian two-fluid model in computational fluid dynamics. The purpose was to estimate the thermal potential to multi-stage a combined heat and power boiler by integration therein of a communicating gasification reactor, which utiliz
Popular science summary: Climate change, and its effect on nature, is presently a hot research topic. Many studies have focused on the effect of recent climate change on breeding and spring migration in birds. Several bird populations have been shown to advance migration or breeding. It has been suggested that if they do not do this they might miss optimal breeding conditions such as peak food av
På grund av den världsomfattande diskussionen rörande ”klimatförändringen” som pågått under de senaste åren, så har försök gjorts för att få människor att ändra sina vanor och för att hitta alternativa energikällor. I dag är det fossila bränslen som dominerar som energikällor men eftersom de ger upphov till höga koldioxidhalter pågår det forskning för att ta fram alternativa bränslen. En grupp av There has been a worldwide debate about “the climate change” over the past years, accompanied with the efforts in finding a more environmental friendly way to live. One area of research is to find replacements for the fossil fuels, which is the major energy source today. The aim of this project is to investigate the atmospheric properties of a new potential group of biofuels, i.e. the group of com
During the fall of 2012, a social service center in Sweden re-organized their social assistance organization. From having three teams, where two teams consisted of one kind of an occupational group and the third one of another occupational group, the organization today exists of two teams with both occupational groups in each team. The aim of this study was to find out and see how the collaboratio
Denna uppsats problematiserar och undersöker målbolagsstyrelsens ställning vid offentliga uppköpserbjudanden genom att belysa oklarheter som råder kring målbolagsstyrelsens agerande, framförallt till följd av att ABL inte har anpassats till takeover-reglerna och vice versa. Målbolagsstyrelsens komplexa ställning exemplifieras i denna uppsats av en utredning av vilka överväganden och vilket aktieboThis thesis problematizes and investigates the role of the board in a public company facing a friendly takeover bid. It does this by illuminating ambiguities which concern actions of the target company board, due to the fact that the Swedish Companies Act and the Swedish Takeover Rules have not been brought into conformity with one another. The complicated role of the board is exemplified by the i
The thesis focuses on multi-physics simulation of a gas inflator for inflation of airbags. The need of multi physics simulations extends to many other engineering and industrial applications and has become an extensive area of research. Main focus is on the Fluid Structure Interaction (FSI) within the field of multi-physics or coupled physics simulation. The purpose is to study the flow, the membr
This study examined how amount of social media use, type of content and type of engagement relate to adolescent mental health and wellbeing. It also explored whether gender and social comparison orientation moderated these relationships. Using a cross-sectional survey study design, objective screen time data and self-report measures of content (photo, video, and text) and engagement (passive vs. a
Extrema klimathändelser, såsom betydande översvämningar, utgör en risk för naturkatastrofer. På grund av klimatförändringarnas effekter förväntas södra Sverige få fler betydande regnväder som kan orsaka översvämningar i allt högre grad med mängden utsläpp. I denna studie undersöks dagens och framtidens översvämningsrisk i ett litet område i denna region, inom Kävlinges avrinningsområde. I det framExtreme climate events, such as significant flooding, pose a natural disaster risk. Due to climate change effects, the southern region of Sweden is anticipated to receive more significant rainstorms that could cause flooding increasingly with the quantity of emissions. This study examines the present-day and future climate’s flooding risk in a small area in this region, within the Kävlinge Watersh
In vitro airway epithelial models play a crucial role in respiratory research, particularly for studying barrier function, drug delivery, and host-pathogen interactions. This thesis aimed to characterize electrospun polycaprolactone (e-PCL) in a 96-well plate format as a potential platform for supporting the attachment, proliferation, and differentiation of human airway epithelial cells (Calu-3) u
Stuttering is a disorder characterized by transient disruptions in speech motor production. This article is focused on the characteristics of stuttering and the immediate vocal tract mechanisms resulting in stuttered speech disruptions. A range of observations from an initial series of studies on the motor characteristics of stuttering events in adults is presented, combined with a narrative revie
Background: Concern was raised within the International Contact Dermatitis Research Group (ICDRG) regarding the scoring of weak allergic versus doubtful patch test reactions. Objective: To investigate the degree of uniformity in patch test reading. Methods: Five series of fictive contact dermatitis cases were written up by the study organizer and presented to expert participants. Each series was s
Intolerance of uncertainty (IU), cognitive avoidance (CA), positive beliefs about worry (PBW) and a tendency to view everyday problems as threats, termed negative problem orientation (NPO), are cognitive vulnerabilities associated with symptoms of anxiety and depression in adults, with fewer studies examining all four vulnerabilities in youth. In this study, validated measures of IU, CA, PBW and N
Background: Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF). Research Question: What are the current practices for assessment of sleep and nocturnal hypoxemia in PF, and what are the research priorities and outcome measures of importance for nocturnal oxygen therapy (NOT)? Study Design and Methods: People with PF and health care professionals (HCPs) with expertise in PF, s
PURPOSE: Irradiation inflicts acute injuries to the intestinal mucosa with rapid apoptosis induction and subsequent reduction in epithelial surface area. It may therefore be assumed that the intestinal barrier function is affected. The aim of this study was to compare the mucosal permeability in irradiated rectum and nonirradiated sigmoid colon from patients subjected to radiation therapy before s
All colonies of the fungus-growing termite Macrotermes natalensis studied so far are associated with a single genetically variable lineage of Termitomyces symbionts. Such limited genetic variation of symbionts and the absence of sexual fruiting bodies (mushrooms) on M. natalensis mounds would be compatible with clonal vertical transmission, as is known to occur in Macrotermes bellicosus. We invest
Objective: To determine the diagnostic accuracy of prenatal ultrasound in detecting coarctation of the aorta (CoA). Methods: An individual participant data meta-analysis was performed to report on the strength of association and diagnostic accuracy of different ultrasound signs in detecting CoA prenatally. MEDLINE, EMBASE and CINAHL were searched for studies published between January 2000 and Nove
