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NMR (nuclear magnetic resonance) spektroskopi, är en omfattande teknik som har många applikationer inom kemin. Det kan användas inom organisk kemi som stöd och underlag till strukturbestämning av molekyler, men framför allt finns det många tillämpningar inom biokemi och molekylärbiologi där tekniken utnyttjas; NMR är mycket användbart för att studera biomolekylers strukturer och biologiska processThis study aims to present a protocol for pH determination in biomolecular NMR samples by evaluating the pH dependence of chemical shifts in the most commonly reported buffer molecules in the BioMagResBank (BMRB). Whilst there exists multiple methods and protocols for intrinsic NMR pH determination and various molecules have been proposed as pH indicators, there is no method to determine the actua

Ensuring close control of critical quality attributes (CQAs), such as post-translational modifications (PTMs), in therapeutic monoclonal antibodies (mAbs) is essential for maintaining function and batch homogeneity in large-scale production. Common PTMs include deamidation, fragmentation, oxidation, charge variants, and glycosylations. This study aimed to evaluate CQA variations and correlate the

The overall aim of this thesis was to provide a representative estimate of the potential impacts of climate change and increased atmospheric CO2 concentrations on Swedish forest ecosystems and the key ecosystem services they provide. In order to achieve this task, fi rst LPJ-GUESS, a process-based regional ecosystem modelling framework, was applied to explore how possible shifts in climatic zones

Introduction Given the safety issues of nonsteroidal anti-inflammatory drugs (NSAID) and the robustness of guidelines, making treatment choices in daily clinical practice is increasingly difficult. This study aimed systematically to analyse the opinions of a multidisciplinary European expert panel on the appropriateness of different NSAID, with or without the use of a proton pump inhibitor (PPI),

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. Aims. We aim to determine C, N, and O abundances in stars of Galactic open clusters of the Gaia-ESO survey and to compare the observed abundances with those predicted by current stellar and Galactic evolution models.

Popular Abstract in Swedish De manliga könshormonerna, sk. androgener, spelar en nyckelroll under foster-utvecklingen av de manliga inre (t ex. blåshalskörtel/prostata) och yttre (t ex. penis) könsorganen. Androgenerna stimulerar även tillväxten av desamma under puberteten samt upprätthåller de manliga kroppsegenskaperna under vuxenlivet. De två huvudsakliga androgenerna är testosteron (T) samt 5αAndrogen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, respectively. Variation in CAG repeat length had been associated with a number of andrological disorders, where

Objective. Gastrointestinal (GI) symptoms are common in cirrhosis and have an impact on quality of life. Their pathophysiology and their relation to energy intake have not been fully elucidated and the effect of liver transplantation on GI symptoms has not been studied. We aimed to prospectively evaluate GI symptoms and their determinants before and after transplantation and their potential relati

Background: Postoperative pneumonia is an acknowledged risk following surgical procedures, for which there is currently no prophylactic treatment. Different methods have been tried with varying results, such as the administration of antibiotics or chlorhexidine to reduce pathogens in the oral flora. This study explores a prophylactic oral treatment with a suspension of two lactobacillus-strains, L

The aim of our study was to examine how the staff at community residences handles the residents’ right and ability to make choices and decisions regarding their health, in relation to their disability. We investigated this through semi-structured interviews. Our population consisted of 7 staff members from 4 different community residences, in 3 municipalities in Skåne, Sweden. We constructed an in

This paper analyzes if there exist a statistical relationship between liquidity on stock, listed at NASDAQ OMX Nordic Stockholm, and financial stress. Liquidity is approximated by volume turnover, and financial stress is represented by SIXVX implied volatility index. To find out if stock liquidity responds differently to financial stress, depending on capitalization value, the stocks were divided

In this essay we aim at finding an appropriate flash estimator of the quarterly Swedish private consumption (PK). With the aid of the statistics program TRAMO we study if monthly data from the consumer survey (HIP) and retail industry (DH) can be used in a transfer function model (TFM) to forecast PK. In the work of assessing the state of the market and the business trend, fast information from th

When it comes to political representation, all over the world women almost always make up a minority of representatives in the legislative bodies. The Scandinavian countries in general and Sweden in particular have though been exceptions to this rule with, when compared to other countries, a rather high percentage of women in elected positions. This development took off in the seventies: during th

Facing interdependent, systemic problems such as resource depletion and climate change, recent civil society organizations’ (CSOs) strategies seem to address only parts of the current challenges the world faces. Different and partly new modes of learning, organization and innovation are emerging on the agenda of several CSOs operating in the field of sustainability. The linkages in between the CSO

This qualitative study is about how individual supportive conversation between school welfare officers and pupils in upper secondary school is carried out. The major interest of the study was to explore the problems that school welfare officers have during forced or involuntary supportive conversations with pupils, and how those problems can be understood and solved with the concept of strategies.

Many minority groups are subjected to discrimination in today’s society. The reasons behind this unfair treatment are often based upon morally irrelevant grounds. These grounds are in most cases shared by all the members of the minority group. The focal points of this essay are in the court cases that concern affirmative action at the Swedish University of Agricultural Sciences and Lund University

Våldtäktsbrottet har, inom svensk rätt, genomgått omfattande förändringar de senaste decennierna. Begreppet har breddats och kommit att innefatta allt fler sexuella handlingar. Utvecklingen har följts av omfattande diskussioner samt medialt omdebatterade domar. Den så kallade samtyckesregleringen, där rekvisiten våld och hot avskaffas till förmån för ett bristande samtycke, har haft en central posUnder Swedish Penal Law the rape offense has undergone extensive changes in the recent decades. The concept of rape has been broadened and extended to cover more sexual acts then before. The trend has been followed by extensive discussions and media controversial judgments. The so-called consent regulation, where the elements of violence and threats would be replaced in favor of the victim’s lack