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Genetic Characterisation of Human ABO Blood Group Variants with a Focus on Subgroups and Hybrid Alleles

Popular Abstract in Swedish Karl Landsteiner upptäckte blodgruppssystemet ABO och beskrev principen för den antigen-antikroppsreaktion som gäller än idag. För att utföra en säker blodtransfusion krävs det att individens ABO-blodgrupp är känd och därefter kan passande givarblod transfunderas. A- och B-generna ger upphov till enzymen A- respektive B-transferas. Blodgrupp O beror på olika defekter sABO is the most important blood group system in transfusion medicine and transplantation immunology. The ABO blood groups differ by the presence or absence of antigens on RBCs and antibodies in plasma. Accurate determination of ABO status is critical. Genomic typing can increase the precision of blood group determination in complicated cases, e.g. when variant expression of A or B antigen is encou

Retinal examination intervals in diabetic patients on diet treatment only

PURPOSE: The aim of the present study was to examine whether type 2 diabetic patients with good metabolic control achieved on diet treatment only, developed sight-threatening retinopathy during a four-year follow-up period. METHODS: A retrospective four-year follow-up study was carried out including all diabetic patients on diet treatment only, registered at the out-patient clinic at the Departmen

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Rome in Sweden? The Catholic Offensive in Ecumenical-National Context Since World War II, ecumenical principles have been used as historical measures. This has led to re-interpretations of historical events and to alterations of sources, for example the letters and diaries by Elisabeth Hesselblad, the renewer of St. Birgitta’s order. In the literature on the Swedish Archbishop Nathan Söderblom, th

A system perspective on the heating of detached houses

Primary energy use, emission and the cost of whole energy system chains, from natural resource to end-User, were analysed, in a Swedish context,, hen heating detached houses. Both electricity-based systems employing heat Pumps. boilers. or resistance heaters. and local fuel-based systems (e.g. natural gas. oil and wood fuel) were considered. The base-load electricity was Produced in stand-alone po

Comparison of temperature effects on soil respiration and bacterial and fungal growth rates

Temperature is an important factor regulating microbial activity and shaping the soil microbial community. Little is known, however, on how temperature affects the most important groups of the soil microorganisms, the bacteria and the fungi, in situ. We have therefore measured the instantaneous total activity (respiration rate), bacterial activity (growth rate as thymidine incorporation rate) and

Comparison of quantitative ultrasound measurements in calcaneus with DXA and SXA at other skeletal sites: a population-based study on 280 children aged 11-16 years

We performed ultrasound measurements (QUS) of the calcaneus in a population-based setting on 280 healthy children, aged 11-16 years, from a small urban area in southern Sweden. The results are compared with dual-energy X-ray absorptiometry (DXA) measurements in the total body, the lumbar spine and the hip, as well as single-energy X-ray absorptiometry (SXA) of the forearm. Normative data and corre

Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC

Work ability- Health professionals' perspectives and rehabilitation outcomes

Popular Abstract in Swedish Arbetsförmåga har kommit att bli ett viktigt begrepp i samhället, men också för individen. Det saknas i dag en tydlig definition av arbetsförmåga, trots att det har en stor inverkan på hur sjukförmåner distribueras och också för den enskilde individens möjlighet att försörja sig. I västvärlden är arbetsförmåga ofta diskuterat i relation till sjukskrivning och en åldrad The overall aim of this thesis was to deepen the understanding of work ability by analyzing how different health professionals experience and perceive work ability and assessments of work ability, and also by analyzing rehabilitation outcomes that are related to work ability. The focus has been on musculoskeletal disorders with associated psychosocial factors. Method. The general approach was indu

Profile of TP53 gene mutations in sinonasal cancer

Genetic alterations underlying the development of the cancer of the nose and paranasal sinuses (sinonasal cancer, SNC), a rare cancer that can be included in the group of head and neck cancers, are still largely unknown. We recently reported that TP53 mutations are a common feature of SNC, with an overall frequency of 77%, and they show association to adenocarcinoma and wood-dust exposure [15]. In

Physical activity and its effect on bone in the short- and long- term perspective.

Popular Abstract in Swedish Benskörhet (osteoporos), är ett komplext, multifaktoriellt tillstånd som utvecklas i det tysta fram till den dag man drabbas av en fraktur. De senaste 40 åren har antalet benskörhetsfrakturer ökat och i dag beräknas varannan kvinna och var fjärde man någon gång drabbas av en eller flera osteoporosrelaterade frakturer. Exempel på sådana benbrott är frakturer i kota, höftOsteoporosis is a growing problem worldwide where Sweden has one of the highest fragility fracture incidences in the world. The growing years are thought to be an opportune time to build strong bones and the enhancement of peak bone mass (PBM) has been suggested as a prevention strategy for osteoporosis. Most exercise intervention studies in children, evaluating the accrual of areal bone mineral d

Outcome after HSCT in Philadelphia chromosome positive acute lymphoblastic leukemia in Sweden: a population-based study

Even in the tyrosine kinase inhibitor era, allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as standard care for adult Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL). In this retrospective national study, we have reviewed the outcome after HSCT in Sweden for adult Ph-positive ALL between 2000 and 2009. In total, 51 patients with median age 42 (range 20-66) years

Feasibility for mapping cartilage t1 relaxation times in the distal metacarpus3/metatarsus3 of thoroughbred racehorses using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dgemric): normal cadaver study

Osteoarthritis of the metacarpo/metatarsophalangeal joints is one of the major causes of poor performance in horses. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) may be a useful technique for noninvasively quantifying articular cartilage damage in horses. The purpose of this study was to describe dGEMRIC characteristics of the distal metacarpus3/metatarsus3 (Mc3/Mt

An evaluation of the interference of hydroxycobalamin with chemistry and co-oximetry tests on nine commonly used instruments

The administration of hydroxocobalamin (OHCob), alone or with sodium thiosulfate, is a standard therapy for cyanide poisoning. OHCob is a red chromophore, and its interference with co-oximetric and colorimetric laboratory measurements has been evaluated in a few conflicting reports. The interference of OHCob was investigated in samples spiked with 10 different concentrations of OHCob (0-1500 mg/L)

Testing avian compass calibration: comparative experiments with diurnal and nocturnal passerine migrants in South Sweden.

Cue-conflict experiments were performed to study the compass calibration of one predominantly diurnal migrant, the dunnock (Prunella modularis), and two species of nocturnal passerine migrants, the sedge warbler (Acrocephalus schoenobaenus), and the European robin (Erithacus rubecula) during autumn migration in South Sweden. The birds' orientation was recorded in circular cages under natural clear

CT lung densitometry in young adults with alpha-1-antitrypsin deficiency

Background: Severe (PiZZ) and moderate (PiSZ) alpha-1-antitrypsin (AAT) deficiency predispose to lung emphysema, especially in smokers. We hypothesized that multi-slice computed tomography (CT) might be superior to pulmonary function tests (PFT) to detect lung emphysema in AAT-deficient individuals at the age of 32 years. Methods: A subgroup of PiZZ and PiSZ individuals identified during the Swedi

Colposcopy after cervical dysplasia: psychological aspects

The aim of this thesis was to conduct a prospective investigation of anxiety and its long-term effects on women referred for colposcopy after an abnormal cervical smear. The thesis comprises four articles, all based on a study of the current life situation, anxiety (Spielberger's state-trait anxiety inventory, STAI), depression (Montogomery Isberg Depression Rating Scale self-rate), psychosexualit

Non-invasive optical monitoring of free and bound oxygen in humans

Background: Possibilities of detecting oxygen - both in its free form, as gas in the lungs, and in its bound form, as oxygenated hemoglobin - have been explored in this thesis. Perfusion and oxygenation of vital organs (e.g., heart, brain and kidneys) may be severely compromised in critical illness or major trauma, which is why blood is rapidly diverted to those organs to improve chances of surviv