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Background: Cost-effectiveness models in Parkinson’s disease often include health states based on Hoehn and Yahr (H&Y) and time in ‘off’. Few studies have investigated utilities in these health states. Objective: The aim of this study was firstly to explore utilities in health states based on H&Y and off-time, and secondly to investigate to what extent H&Y and off-time correlated with

Background: To identify apolipoprotein E (APOE)-specific factors that may predict life expectancy after a diagnosis of Alzheimer’s disease (AD). Method: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, clinical-practice-based, multicentre study that includes 999 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibitor (ChEI) therapy (tim

Large-scale radiation emergency scenarios involving protracted low dose rate radiation exposure (e.g. a hidden radioactive source in a train) necessitate the development of high throughput methods for providing rapid individual dose estimates. During the RENEB (Running the European Network of Biodosimetry) 2019 exercise, four EDTA-blood samples were exposed to an Iridium-192 source (1.36 TBq, Tech

Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multi

Background: Sedation and analgesia are recommended during targeted temperature management (TTM) after cardiac arrest, but there are few data to provide guidance on dosing to bedside clinicians. We evaluated differences in patient-level sedation and analgesia dosing in an international multicenter TTM trial to better characterize current practice and clinically important outcomes. Methods: A total

Background: Emergency surgery for acute type A aortic dissection in patients with previous cardiac surgery is controversial. This study aimed to evaluate the association between previous cardiac surgery and outcomes after surgery for acute type A aortic dissection, to appreciate whether emergency surgery can be offered with acceptable risks. Methods: All patients operated on for acute type A aorti

Background: Patients with atrial fibrillation (AF) have an increased dementia risk dementia. We aimed to study the effect of antihypertensive drugs on dementia in AF patients. Methods: Included patients were ≥45 years diagnosed with AF in Swedish National Patient Register (n = 160,251; 89,723 men and 70,528 women) and alive on January 1, 2007. We excluded patients with dementia before onset of AF.

Purpose: The COVID-19 pandemic led to a drastic expansion in utilizing telemedicine, circumventing some of the geographical barriers to accessing pain care. However, uncertainties around the impact of telemedicine across various sociodemographic groups still exist, prompting further exploration. Therefore, this study aimed to evaluate the impact of sociodemographic factors in telemedicine utilizat

CONTEXT: Mild autonomous cortisol secretion (MACS) is associated with increased mortality in patients with adrenal incidentalomas (AI), but little is known regarding the potential risk associated with non-functional adrenal adenomas (NFAA), which constitute the majority of AI.OBJECTIVE: Compare mortality risk in patients with NFAA, and different levels of MACS, to matched controls.METHOD: This was

High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generall

This study aimed to understand the exploitation of bacterial strains used in various combinations to assist in the fermentation of seaweeds. The topic stems from the need to consider the valorization of seaweeds due to their abundance in natural habitats as well as their use as an innovative and sustainable food. Fermentation is a traditional method that has been utilized for food preservation. It

Nasal administrering är en administeringsmetod där läkemedel inhaleras genom näsan. Metodens huvudsakliga syfte är att snabbt och effektivt behandla lokala symtom. Men på senare tid har det även ökats intresse för att uppnå en systemisk effect, där läkemedlet når blodomloppet och därigenom påverkar hela kroppen. Näshålan är ungefär 15-20 ml, med en yta på cirka 150 cm2 och är uppdelad i två symmIntranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. Moreover, drugs can bypass the blood-brain barrier and directly reach the brain through the olfactory route

En av de mest centrala författningarna på förmögenhetsrättens område är den svenska avtalslagen. Lagen tillkom genom ett juridisk samarbete mellan de nordiska länderna. Den antogs 1915 i Sverige, och därefter även i de övriga nordiska länderna. Då lagen nu uppnått en hög ålder väcks frågan om den behöver reformeras, eller om den än idag fungerar väl i det moderna samhället. Den här uppsatsen syftaOne of the most central acts on commercial matters in Sweden is the Swedish Contract Act. The act was created through a legal cooperation between the Nordic countries. It was adopted in 1915 in Sweden, and afterwards in the other Nordic countries. As the act now has reached an advanced age, the question arises if there is a need for a reformation, or if it still works well in the modern society. T

Background: Scotland possesses the worst mortality outcomes and slowest improvement in life expectancy of Western Europe. Within Scotland, stark inequalities exist in both morbidity and mortality. There remains paucity in assessment of subnational variation in disease burden. Aim: This thesis explored geographical inequalities in burden of disease (BoD) across 32 Scottish authorities. Secondary an

Titel: Solceller med tillhörande lagringsbatteri i flerbostadshus – Analys av lönsamhet och möjlighet att uppfylla kommande NNE-krav Författare: Frida Hansson, Christian Bakgrund: Den 1 januari 2021 träder nya, skärpta krav på byggnaders energiprestanda i kraft. Dessa krav kallas nära-nollenergikrav (NNE-krav) eftersom de tillkommer som en åtgärd för att öka antalet nära-nollenergibyggnader i SveTitle: PV-cells and storage batteries in multifamily residential buildings – Analysis of the profitability and the ability to meet the upcoming nearly zero-energy requirements Authors: Frida Hansson, Christian Jedhammar Supervisors: Karin Adalberth, Building Physics, LTH Ludvig Andersson, Teknik och hållbarhet, NCC Building SE Examiner: Åsa Wahlström, Installation Technology, LTH Problem: On 1 Jan

Recent policy developments on the global, regional and national levels have materialised strategic goals for building resilience. Implementing resilience fundamentally requires operationalising the concept in order to make it measurable. This thesis scoped for professional resilience measurement methodologies across grey literature and analysed their organisational purposes and specifics of measur

The development of English into a dynamic and diverse compound of language varieties has led to a spread of non-standard grammar features. Such linguistic development affects language education, and thus the significance of common non-standard grammar features needs to be explored. The purpose of this study was thus to investigate the significance of traditional “correctness” of grammar in relatio